首頁師資〉教師指導學生

謝達斌

謝達斌 (Dar-Bin Shieh. Ph.D.)                                     

口腔醫學研究所     特聘教授   分機:5377   Email: darbinshieh@gmail.com

個人網址:http://140.116.60.44/dentist_stu/main.php?mod=teacher&func=show_teacher&teapro_id=1

專長與研究興趣:

奈米科技於臨床與基礎醫學之應用、分子腫瘤學、粒線體醫學、細胞生物物理與行為、生醫影像學及結構生物學

近五年代表作:

  1. Abedini MR, Wang PW,Huang YF, Kong B, Cao MJ, Chou CY*, Shieh DB*, Tsang BK*. Cell Fate Regulation by Gelsolin in Human Gynecologic Cancers. Accepted by PNAS.
  2. Wang PW, Abedini MR, Yang LX, Ding AA, Figeys D, Chang JY, Tsang BK*, Shieh DB*. Gelsolin Regulates Chemosensitivity in Human Head-and-Neck Cancer. International Journal of Cancer, Article first published online : 23 MAY 2014, DOI: 10.1002/ijc.28928.
  3. Lan SM, Wu YN, Wu PC, Sun CK, Shieh DB*, Lin RM*(2014 Feb). Advances in the Noninvasive Functional Imaging of Bone. Academic Radiology, 21(2), 281-301.(SCI). (Review article)
  4. Cheng TM, Murad YM, Chang CC*, Yang MC, Baral TN, Cowan A, Tseng SH, Wong A, MacKenzie R, Shieh DB, Zhang JB* (2014 Mar). Single domain antibody against carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) inhibits proliferation, migration, invasion and angiogenesis of pancreatic cancer cells. European Journal of Cancer, 50(4), 713-721.
  5. Li TJ, Huang CC, Ruan PW, Chuang KY, Huang KJ, Shieh DB*, Yeh CS* (2013 Oct). In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy. Biomaterials, 34(32), 7873-7883.(SCI)
  6. Chang CM, ChiouLF, Shieh DB*, Lee GB* (2013 Oct). Integrated three-dimensional system-on-chip for direct quantitative detection of mitochondrial DNA mutation in affected cells. Biosensors & Bioelectronics, 48, 6-11.
  7. Jeng YR*, Lin TT, Peng SR, Huang JS, Shieh DB* (2013 Jul). Topical lasing enhances enamel fluoride uptake and tribological properties. Journal of Dental Research, 92(7), 655-660, Cover story,http://jdr.sagepub.com/content/92/7.cover-expansion.
  8. Chiou LF, Huang PY, Chiang WF, Wong TY, Lin SH, Lee YC*, Shieh DB*(2013 Feb). Oral cancer diagnostics based on infrared spectral markers and wax physisorption kinetics. Analytical and Bioanalytical Chemistry, 405(6), 1995-2007.
  9. Hou CC, Tsai TL, Su WP, Hsieh HP, Yeh CS, Shieh DB*, Su WC*(2013 Jul). Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly(lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway. International Journal of Nanomedicine, 8(6), 2689-2707.
  10. ReiszRR, HuangTD, RobertsE, Peng SR, Sullivan C, Stein K, LeBlanc A, Shieh DB, Chang RS, Chiang CC, Yang CW, Zong SM (2013 April 11). Dinosaur embryology: inside the bones of an Early Jurassic sauropodomorph from China. Nature, 496, 210-214, Cover story, http://www.nature.com/nature/journal/v496/n7444/full/nature11978.html.
  11. Chu HL, Cheng TM, Chen HW, Chou FH, Chang YC, Lin HY, Liu SY, Liang YC, Hsu MH, Wu DS, Li HY, Ho LP, Wu PC, Chen FR, Chen GS, Shieh DB, Chang CS, Su CH, Yao Z, Chang CC (2013 Aug 14).Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials. ACS Applied Materials & Interfaces, 5(15), 7509-7516.
  12. Sun HY, Lin CC, Lee JC, Wang SW, Cheng PN, Wu IC, Chang TT, Lai MD, Shieh DB,Young KC(2013 Aug). Very-low density lipoproteins and lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. Gut, 62(8), 1193-1203.
  13. Wu YN*, Wu PC, Yang LX, Ratinac KR, Thordarson P, Jahn KA, Chen DH, Shieh DB, Braet F. (2013 Sep). The Anti-Cancer Properties of Iron Core-Gold Shell Nanoparticles in Colorectal Cancer Cells. International Journal of Nanomedicine, 8(8), 3321-3331.
  14. Tsai MR, Shieh DB*, Lou PJ, Lin CF, Sun CK*(2012 May). Characterization of oral squamous cell carcinoma based on higher-harmonic generation microscopy. Journal of Biophotonics, 5(5-6), 415-424.
  15. Liu YC, Wu PC, Shieh DB*, Wu SN* (2012 Mar). The effects of magnetite (Fe3O4) nanoparticle on electroporation-induced inward current in pituitary tumor (GH3) cells and in RAW 264.7 macrophages. International Journal of Nanomedicine,7, 1687-1696.
  16. Tsai TL, Hou CC, Wang HC, Yang ZS, Yeh CS, Shieh DB*, Su WC* (2012 Oct). Nucleocytoplasmic transport blockage by SV40 peptide-modified gold nanoparticles induces cellular autophagy. International Journal of Nanomedicine, 7, 5215-5234.
  17. Rosen JE, Chan L, Shieh DB, Gu FX* (2012 Apr). Iron oxide nanoparticles for targeted cancer imaging and diagnostics. (Review article) Nanomedicine-Nanotechnology Biology and Medicine, 8(3), 275-290.
  18. Hsu YH, Wei CC, Shieh DB, Chan CH, Chang MS (2012 Nov). Anti-IL-20 Monoclonal Antibody Alleviates Inflammation in Oral Cancer and Suppresses Tumor Growth. Molecular Cancer Research, 10(11), 1430-9.                                                                            
  19. Su WP, Cheng FY, Shieh DB, Yeh CS, Su WC (2012 Aug). PLGA nanoparticles co-delivery paclitaxel and Stat3 siRNA overcome cellular resistance in lung cancer cells. International Journal of Nanomedicine, 7, 4269-4283.
  20. Wu YN, Chen DH, Shi XY, Lian CC, Wang TY, Yeh CS, Ratinac K, Thordarson P, Braet F, Shieh DB* (2011Aug). Cancer Cell Specific Cytotoxicity of Non-Oxidized Iron Elements in Iron Core-Gold Shell Nanoparticles. Nanomedicine-Nanotechnology Biology and Medicine , 7(4), 420-427.
  21. Chang CM, ChiouLF, Wang PW, Shieh DB*, Lee GB* (2011Aug). A microfluidic system for fast detection of mitochondrial DNA deletion. Lab on a Chip, 11(16), 2693-2700.
  22. Jeng YR*, Lin TT, Hsu HM, Chang HJ, Shieh DB* (2011 May). Human Enamel Rod Presents Anisotropic Nanotribological Properties. Journal of the Mechanical Behavior of Biomedical Materials, 4(4), 515-522.
  23. Tsai MR, Chen SY, Shieh DB*, Lou PJ, Sun CK* (2011Aug). In vivo optical virtual biopsy of human oral mucosa with harmonic generation microscopy. Biomedical Optics Express, 2(8), 2317-2328.
  24. Wu YN*, Yang LX, Shi XY, Li IC, Biazik JM, Ratinac KR, Chen DH, Thordarson P, Shieh DB, Braet F (2011 July). The selective growth inhibition of oral cancer by iron core-gold shell nanoparticles through mitochondria-mediated autophagy. Biomaterials, 32(20), 4565-4573.
  25. Huang CC, Chuang KY, Chou CP, Wu MT, Sheu HS, Shieh DB, Tsai CY, Su CH, Lei HY, Yeh CS (2011). Size-control synthesis of structure deficient truncated octahedral Fe3δO4 nanoparticles: high magnetization magnetites as effective hepatic contrast agent. Journal of Materials Chemistry, 21(20), 7472-7479.
  26. Chou SW,Shau YH, Wu PC,Yang YS,Shieh DB*, Chen CC* (2010 Sep). In vitro and in vivo Studies of FePt Nanoparticles for Dual Modal CT/MRI Molecular Imaging. Journal of the American Chemical Society, 132(38):13270-13278, Cover story, http://pubs.acs.org/doi/abs /10.1021/ja1035013.
  27. TsaiTL, Shieh DB*, YehCS, Tzeng Y, Htet K, ChuangKS, Hwu JR*, Su WC* (2010Sep). The Down Regulation of Target Genes by Photon Activated DNA Nanoscissors. Biomaterials,31(25):6545- 6554.
  28. Chang CM, ChiouLF, Lin CC, Shieh DB*, Lee GB* (2010 Aug). Three-Dimensional Microfluidic Chip for Extraction of Mitochondrial DNA. Microfluidics and Nanofluidics, 9(2-3), 489-498.
  29. Lai YH, Yang JT*, Shieh DB* (2010 Feb). A Microchip Fabricated with a Vapor-diffusion Self-assembled- monolayer Method to Transport Droplets across Superhydrophobic to Hydrophilic Surfaces. Lab on a Chip, 10(4):499-504.
  30. Shieh DB, Li RY, Liao JM, Chen GD, Liou YM (2010 May). Effects of Genistein on ß-catenin Signaling and Subcellular Distribution of Actin-Binding Proteins in Human Umbilical CD105-Positive Stromal Cells. Journal of Cellular Physiology, 223(2), 423-434.
  31. Hsu MH, Fang WF, Lai YH, Yang JT*, Tsai TL, Shieh DB (2010 Oct). Enhanced mobile hybridization of gold nanoparticles decorated with oligonucleotide in microchannel devices. Lab on a Chip, 10(19): 2583- 2587.
  32. Sun HY, Chen SF, Lai MD, Chang TT, Chen TL, Li PY, Shieh DB, Young KC (2010 Mar). Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins.Clinica Chimica Acta, 441(5-6), 336-344.