首頁師資〉教師指導學生

王志堯

王志堯  (Wang, Jiu-Yao, M.D., Ph.D.)

小兒學科 教授   

分機:5604    E-mail: a122@mail.ncku.edu.tw

個人網址:http://imm.med.ncku.edu.tw/jyw-1.htm

 

研究興趣

 

1.      肺泡表面蛋白在氣喘過敏發炎所扮演的角色:肺泡表面蛋白SPASPD除了在肺部扮演第一線免疫防禦外,尚可結合過敏原,並使得IgE不與過敏原結合,同時我們發現免疫蛋白可與淋巴球表面附著蛋白,抑制其生成反應,具有免疫調控的作用,進一步的研究在於SPA/SPD,如何在接合Adhesion Molecular後的信息傳遞反應,來達到免疫的調控反應。

2.      肺泡表面蛋白是否能作為基因治療的非病毒型,嶄新的載體,達到自氣管吸入後進行gene transfer及基因免疫接種的目的。

3.      台灣地區好發過敏氣喘家族的HLA typing及氣喘基因的研究。

4.      塵蹣過敏原選殖及抗體工程研究。

 

近五年代表作

1.    Jiu-Yao Wang, Reid KBM. 2007. The immunoregulatory roles of pulmonary surfactant protein A and D in allergic inflammation of asthma. Immunobiology 212: 417-425

2.    Jiu-Yao Wang, Cherry Guan-Ju Lin, Ya-Hsin Hsiao, Ya-Huei Liou, Lawrence Shih-Hsin Wu. 2007. Single nucleotide polymorphisms and haplotype of MD-1 gene associated with high serum IgE phenotype with mite-sensitive in Taiwanese children. Int J Immunogenet 34: 407-412

3.    Yen-Lin Lin, Chi-Chang Shieh, Jiu-Yao Wang. 2008. The functional insufficiency of human CD4+CD25high T regulatory cells in allergic asthma is subjected to TNF-a modulation. Allergy 63: 67–74

4.    Yung-Ling Lee, Frank D.Gilliland. Jiu-Yao Wang, Yeu-Chin Lee, Yueliang Leon Guo. 2008. Association of FceRIb E237G polymorphism with wheezing varies with air pollution in schoolchildren. Clin Exp Allergy 38:413-420

5.    Chih-Long Chen, Yu-Ming Wang, Chia-Fang Liu, Jiu-Yao Wang. 2008. The effect of water-soluble chitosan on macrophage activation and the attenuation of mite allergen-induced airway inflammation. Biomaterials 29: 2173-2182

6.    Jiu-Yao Wang. 2008. A never ending story in the pursuit of susceptible genes in allergy and asthma. Pediatr Neonatol 49:3−4.