首頁師資〉教師指導學生

辛致煒

辛致煒  (Shin, Jyh-Wei, Ph.D.)

寄生蟲學科 副教授 

分機:5586    E-mail: z8308010@email.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/%7Eparasite/T8308010/T8308010/T8308010c.htm

 

研究興趣

 

1.     陰道鞭毛蟲系統生物學:陰道滴蟲是非病毒源的性病中,最盛行的病原體;而且會提高患者感染人類愛滋病毒的危險性。隨著臨床上抗藥株的增加,陰道滴蟲症儼然成為公共衛生上的重大威脅。同時這是目前世界上擁有最多基因數的物種,這個基因的存在,超過人的基因的總數,這對未來研究對人類有致病性的寄生蟲,都是一個最重要的基礎研究。隨著這隻寄生蟲基因體被解開後,讓人更容易勘得其中緣由。我們目前使用基因表達晶片,二維電泳,miRNA 晶片,來觀察鐵離子對該寄生蟲生理上與致病機轉的影響。

2.    多形性膠質母細胞瘤系統生物學:多形性膠質母細胞瘤 (glioblastoma multiforme; GBM) 是大腦最常見的惡性腫瘤,也是不折不扣的腦癌,如僅使用手術治療,中期存活僅有3-4個月;加上手術後放射治療,可延長至 10 個月;加手術後放療及 BCNU,可將中期存活再延長一點至一年,但是五年存活率一般仍為零。我們目前使用基因表達晶片,二維電泳,miRNA 晶片,array CGH 與大鼠動物模式來探討 GBM 在臨床上致病,癒後等相關之基因表達。並以 Kinase 為主幹,探討 GBM 癌化的訊息傳遞模式。

 

近五年代表作

 

1. Liu, YC (Liu, Yu-Cheng); Shin, JW (Shin, J. W.); Tseng, VS (Tseng, Vincent S.) Discovering indirect gene associations by filtering-based indirect association rule mining. International Journal of Innovative Computing Information and Control. 2011 OCT 7(10):6041-6053

 

2. Kao, HH (Kao, Hsin-Hsin); Wu, CJ (Wu, Chao-Jung); Won, SJ (Won, Shen-Jeu); Shin, JW (Shin, Jyh-Wei); Liu, HS (Liu, Hsiao-Sheng); Su, CL (Su, Chun-Li) Kinase Gene Expression and Subcellular Protein Expression Pattern of Protein Kinase C Isoforms in Curcumin-treated Human Hepatocellular Carcinoma Hep 3B Cells. PLANT FOODS FOR HUMAN NUTRITION  2011 JUN 66(2):136-142

 

3. Tai, CH (Tai, Chien-Hsuan); Shin, JW (Shin, Jyh-Wei); Chang, TY (Chang, Tsuey-Yu); Hsiung, SK (Hsiung, Suz-Kai); Lin, CC (Lin, Chun-Che); Lee, GB (Lee, Gwo-Bin) An integrated microfluidic system capable of sample pretreatment and hybridization for microarrays. MICROFLUIDICS AND NANOFLUIDICS 2011 MAY 10(5):999-1009

 

4. Yeh CY, Shih SM, Yeh HH, Wu TJ, Shin JW, Chang TY, Raghavaraju G, Lee CT, Chiang JH, Tseng VS, Lee YC, Shen CH, Chow NH, Liu HS. Transcriptional activation of the Axl and PDGFR-alpha by c-Met through a ras- and Src-independent mechanism in human bladder cancer. BMC Cancer. 2011 Apr 16;11(1):139.

 

5. Chen PY, Liu HL, Hua MY, Yang HW, Huang CY, Chu PC, Lyu LA, Tseng IC, Feng LY, Tsai HC, Chen SM, Lu YJ, Wang JJ, Yen TC, Ma YH, Wu T, Chen JP, Chuang JI, Shin JW, Hsueh C, Wei KC. Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment. Neuro Oncol. 2010 Oct;12(10):1050-60. Epub 2010 Jul 27.

 

6. Wei KC, Huang CY, Chen PY, Feng LY, Wu TW, Chen SM, Tsai HC, Lu YJ, Tsang NM, Tseng CK, Pai PC, Shin JW. Evaluation of the prognostic value of CD44 in glioblastoma multiforme. Anticancer Res. 2010 Jan;30(1):253-9.

 

7. Wang JN, Shin JW, Chang TY, Wang JY, Wu JM. Decreased proinflammatory cytokines production in children with complicated parapneumonic pleural effusion after intrapleural fibrinolytic treatment. Inflammation. 2009 Dec;32(6):410-8.

 

8. Lin WC, Li SC, Lin WC, Shin JW, Hu SN, Yu XM, Huang TY, Chen SC, Chen HC, Chen SJ, Huang PJ, Gan RR, Chiu CH, Tang P. Identification of microRNA in the protist Trichomonas vaginalis. Genomics. 2009 May;93(5):487-93. Epub 2009 Feb 3.

 

9. Liu CJ, Lien KY, Weng CY, Shin JW, Chang TY, Lee GB. Magnetic-bead-based microfluidic system for ribonucleic acid extraction and reverse transcription processes. Biomed Microdevices. 2009 Apr;11(2):339-50.