首頁師資〉教師指導學生

呂政展

呂政展 (Cheng-Chan Lu, Ph.D.)

病理學科 教授       

分機26414634    E-mail: cclu@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~path/lcc.htm

 

研究興趣:

 

(1)       鼻咽癌易感基因的遺傳定位、鑑定及無編碼RNA的致癌機轉

    Genetic mapping and positional cloning of NPC susceptible locus, genetic variations of non-coding RNA (無編碼RNA microRNA) associated with the genetic susceptibility to nasopharyngeal carcinoma (NPC), miRNA biogenesis, mechanism of dysregulation of microRNA expression associated with carcinogenesis, molecular pathogenetic mechanism of carcinogenesis

(2)       B型肝炎病毒分子生物學及分子病理研究,基因轉譯調控及致癌機轉

    The transcriptional and post-transcriptional mechanism of HBV surface gene expression, deregulation of hepatitis B virus surface gene expression associated with hepatocarcinogenesis, transcriptional repressor and repressor complex involved in deregulation of hepatitis B viral gene expression.

 

Techniques used: promoter construction, identification and cloning of pri-miRNA, ac-pre-miRNA, pre-miRNA, miRNA by RNAse protection assay, transfection, deletion mapping, EMSA, immunoprecipitation, immunoblotting, nuclear run-on assay, primer extension analysis, Southern blot, Northern blot, site-specific mutagenesis, nuclear translocation analysis, dual luciferase reporter gene; genotyping techniques: by real-time PCR, PCR-SSOP, -SSP, simple probe.

 

近五年代表作:

1.      Huang TJ, Lu CC*(corresponding author), Tsai JC, Yao WJ, Lu X, Lai MD, Liu HS, Shiau AL. Novel Autoregulatory Function of Hepatitis B Virus M Protein on Surface Gene Expression. Journal of Biological Chemistry 2005(July);280:27742-27754.

2.      Lu CC*, Chen JC, Tsai ST, Jin YT, Tsai JC, Chan SH and Su IJ.   Nasopharyngeal Carcinoma-Susceptibility Locus Is Localized to A 132-kb Segment Containing HLA-A Using High Resolution Microsatellite Mapping. International Journal of Cancer 2005(July);115:742-746.

3.      Lu CC , Sheu BS, Chen TW, Yang HB, Hung KS, Chuang CH, Kao AW,* and Wu JJ.  Host TNF-a -1031 & -863 Promoter Single Nucleotide Polymorphisms Determine the Risk of Benign Ulceration after H. pylori Infection. American Journal Gastroenterology 2005(June);100:1274-1282..

4.      Lu CC, Chen JC, Jin YT, Yang HB, Chan SH and Tsai ST. Genetic susceptibility to nasopharyngeal carcinoma within the HLA-A locus in Taiwanese. International Journal of Cancer 2003;103:745-751.

5.      Fan YF, Lu CC, Chen WC, Yao WJ, Wang HC, Chang TT, Lei HY, Shau AL, and Su IJ. Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology 2001;33: 277-286.