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謝淑珠

謝淑珠  (Shu-Chu Shiesh)

醫技所 教授　

分機：5764    E-mail: hsieh@mail.ncku.edu.tw

個人網址：http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

研究興趣：

  1. 肝膽疾病之致病機制與新治療策略之研究：

探討膽汁酸在肝膽疾病的致病角色。本實驗室探討重點為：(1)氧化壓力與肝膽疾病之關係。(2)代謝壓力在肝膽疾病所扮演的角色與治療新策略的開發。(3) 新生兒膽汁滯留的致病機轉與治療。

  1. 適合體(aptamer)生醫晶片：

利用aptamer及微奈米技術的研發，研發晶片檢測生化標誌的臨床應用。

  1. 代謝體學的研究：

利用LC-MS/MS代謝體技術，開發疾病新標誌及小分子藥物篩選。

近五年代表作：

  1. Chen CY, Tsai WL, Wu HC, Syu MJ, Wu CC, Shiesh SC*. (2008) Diagnostic Role of Biliary Pancreatic Elastase for Cholangiocarcinoma in Patients with Cholestasis. Clin Chim Acta 390:82-89
  2. Wu IC, Shiesh SC, Kuo PH, Lin XZ. High oxidative stress is correlated with frailty in elderly Chinese. J Am Geriatr Soc 2009; 57:1666-1671
  3. Yang YN, Lin HI, Wang JH, Shiesh SC*, Lee GB*. An integrated microfluidic system for C-reactive protein measurement. Biosensors & Bioelectronics 2009; 24:3091-3096
  4. Shiesh SC*, Wiedmeyer HM, Kao JT, Vasikaran SD, Lopez JB. Proficiency Testing of HbA1c: a 4-year experience in Taiwan and the Asian Pacific Region. Clin Chem 2009;55:1876-1880
  5. Huang CJ, Lin HI, Shiesh SC*, Lee GB*. Integrated Microfluidic System for Rapid Screening of CRP Aptamers Utilizing Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Biosensors & Bioelectronics 2010;25:1761-1766
  6. Wu IC, Lin XZ, Liu PF, Tsai WL, Shiesh SC*. Low serum testosterone and frailty in older men and women. Maturitas 2010;67:348-352 (SCI)
  7. Lin JT, Hsiao KJ, Chen CY, Wu CC, Lin SJ, Chou YY, Shiesh SC*. High Resolution Melting Analysis for the Detection of SLC25A13 Gene Mutations in Taiwan. Clin Chim Acta 2011;412:460-465 (SCI)
  8. Chao-Jyun Huang, Hsin-I Lin, Shu-Chu Shiesh, Gwo-Bin Lee. An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers. Biosens Bioelectron 2012, 35 : 50– 55
  9. Yin-He Chen, Hsin-I Lin, Chao-Jyun Huang, Shu-Chu Shiesh, Gwo-Bin Lee. An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment. Microfluid Nanofluid 2012, 13 : 929–939
  10. Weng CH, Hsieh IS , Hung, LY, Lin CI, Shiesh SJ , Chen YL, and Lee GB. An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers. Microfluidics and Nanofluidics, 2013, 753-765.