謝淑珠 (Shu-Chu Shiesh)
醫技所 教授
分機:5764 E-mail: hsieh@mail.ncku.edu.tw
個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1
研究興趣:
- 肝膽疾病之致病機制與新治療策略之研究:
探討膽汁酸在肝膽疾病的致病角色。本實驗室探討重點為:(1)氧化壓力與肝膽疾病之關係。(2)代謝壓力在肝膽疾病所扮演的角色與治療新策略的開發。(3) 新生兒膽汁滯留的致病機轉與治療。
- 適合體(aptamer)生醫晶片:
利用aptamer及微奈米技術的研發,研發晶片檢測生化標誌的臨床應用。
- 代謝體學的研究:
利用LC-MS/MS代謝體技術,開發疾病新標誌及小分子藥物篩選。
近五年代表作:
- Chen CY, Tsai WL, Wu HC, Syu MJ, Wu CC, Shiesh SC*. (2008) Diagnostic Role of Biliary Pancreatic Elastase for Cholangiocarcinoma in Patients with Cholestasis. Clin Chim Acta 390:82-89
- Wu IC, Shiesh SC, Kuo PH, Lin XZ. High oxidative stress is correlated with frailty in elderly Chinese. J Am Geriatr Soc 2009; 57:1666-1671
- Yang YN, Lin HI, Wang JH, Shiesh SC*, Lee GB*. An integrated microfluidic system for C-reactive protein measurement. Biosensors & Bioelectronics 2009; 24:3091-3096
- Shiesh SC*, Wiedmeyer HM, Kao JT, Vasikaran SD, Lopez JB. Proficiency Testing of HbA1c: a 4-year experience in Taiwan and the Asian Pacific Region. Clin Chem 2009;55:1876-1880
- Huang CJ, Lin HI, Shiesh SC*, Lee GB*. Integrated Microfluidic System for Rapid Screening of CRP Aptamers Utilizing Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Biosensors & Bioelectronics 2010;25:1761-1766
- Wu IC, Lin XZ, Liu PF, Tsai WL, Shiesh SC*. Low serum testosterone and frailty in older men and women. Maturitas 2010;67:348-352 (SCI)
- Lin JT, Hsiao KJ, Chen CY, Wu CC, Lin SJ, Chou YY, Shiesh SC*. High Resolution Melting Analysis for the Detection of SLC25A13 Gene Mutations in Taiwan. Clin Chim Acta 2011;412:460-465 (SCI)
- Chao-Jyun Huang, Hsin-I Lin, Shu-Chu Shiesh, Gwo-Bin Lee. An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers. Biosens Bioelectron 2012, 35 : 50– 55
- Yin-He Chen, Hsin-I Lin, Chao-Jyun Huang, Shu-Chu Shiesh, Gwo-Bin Lee. An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment. Microfluid Nanofluid 2012, 13 : 929–939
- Weng CH, Hsieh IS , Hung, LY, Lin CI, Shiesh SJ , Chen YL, and Lee GB. An automatic microfluidic system for rapid screening of cancer stem-like cell-specific aptamers. Microfluidics and Nanofluidics, 2013, 753-765.