首頁師資〉教師指導學生

葉才明

葉才明  (Yeh, Trai-Ming, Ph.D.)

醫技所 教授   分機57945778    E-mail: today@mail.ncku.edu.tw

個人網址:http://mt.ncku.edu.tw/p/412-1151-14490.php?Lang=zh-tw#tabs|Teacher:1

研究興趣

  1. 登革病毒感染之致病機轉。
  2. 病毒感染之治療及預防。

近五年代表作

1、Lu, L.H., C.H. Chao, and T. M. Yeh*. (2019). Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage. J Infect. 78:178-186. (SCI)

2、Chao, C.H., W.C. Wu, Y.C. Lai, P.J. Tsai, G.C. Perng, Y.S. Lin and T.M. Yeh*. (2019). Dengue virus nonstructural protein 1 activates platelets via toll-like receptor 4, leading to thrombocytopenia and hemorrhage. PLoS Pathogens in press (SCI)

3、Chao, C.H., H.R. Chen, Y.C. Chuang and T.M. Yeh*. (2018). MIF-induced autophagy contributes to thrombin-triggered endothelial hyperpermeability in sepsis. Shock 50:103–111. (SCI)

4、Chen, H. R., C.H. Chao, C.C. Liu, T.S. Ho, H.P. Tsai, G.C. Perng, Y.S. Lin, J.R. Wang and T.M. Yeh*. (2018). Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. PLoS Pathogens 14: e1007033. (SCI)

5、Chen, H. R., Y.C. Lai and T.M. Yeh*. (2018). Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate. J. Biomed. Sci. 25: 58-68. (SCI)

6、Lai, Y.C., Y.C. Chuang, C.P. Chang, Y.S. Lin, G.C. Perng, H.C. Wu, S.L. Hsieh and T.M. Yeh*. (2018). Minocycline suppresses dengue virus replication by down-regulation of macrophage migration inhibitory factor-induced autophagy. Antiviral Res. 155: 28-38. (SCI)

7、Chao, C.H., H.R. Chen, Y.C. Chuang and T.M. Yeh (2017) MIF-induced autophagy contributes to thrombin-triggered endothelial hyperpermeability in sepsis. Shock (Epub ahead of print)

8、Wan, S.W., P.W. Chen, C.Y. Chen, Y.C. Lai, Y.T. Chu, C.Y. Hung, H. Lee, H.F. Wu, Y.C. Chuang, J. Lin, C.P. Chang, S.Y. Wang, C.C. Liu, T.Z. Ho, C.F. Lin, C.K. Lee, B.A. Wu-Hsieh, R. Anderson., T.M. Yeh and Lin, Y.S. (2017) Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection. J Immunol .199(8):2834-2844 (SCI)(Co-corresponding author)

9、Lai, Y.C., Y.C. Chuang, C.C. Liu, T.S. Ho, Y.S. Lin, R. Anderson. and T.M. Yeh (2017) Antibodies against modified NS1 wing domain peptide protect against dengue virus infection. Sc. Rep. 7(1): 6975 (SCI)

10、Chen, H.R., Y.C. Chuang, Y.S. Lin, H.S. Liu, C.C. Liu, G.C. Perng and T.M. Yeh(2016) Dengue virus nonstructural protein 1 induces vascular leakage through macrophage migration inhibitory factor and autophagy. PLoS Negl Trop Dis 10(7): e0004828. (SCI)

11、Chuang, Y.C., J. Lin, Y.S. Lin, S. Wang, T.M. Yeh*(2016). Dengue virus nonstructural protein 1-induced antibodies cross-react with human plasminogen and enhance its activation. J Immunol 196(3): 1218-1226. (SCI)

12、Lai, Y.C., Y.C. Chuang, C.P. Chang, T.M. Yeh* (2015) Macrophage migration inhibitory factor plays a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy. Cell Death Dis. 6: e2008. (SCI)

13、Chuang, Y.C., H.R. Chen, and T.M. Yeh (2015) Pathogenic roles of macrophage migration inhibitory factor during dengue virus infection. Mediators of inflammation 2015:547094. (SCI)

14、Chen, H. R. Y. C. Chuang, C. H. Chao, and T.M. Yeh(2015) Macrophage migration inhibitory factor induces vascular leakage via autophagy. Biol Open 4:244-252. (SCI)

15、Chuang, Y.C., Y.S. Lin, H.S. Liu, and T.M. Yeh(2014) Molecular mimicry between dengue virus and coagulation factors induces antibodies to inhibit thrombin activity and enhance fibrinolysis. J. Virol. 88: 13759-68. (SCI)