首頁師資〉專/兼任師資專長

傅子芳

傅子芳 (Tzu-Fun Fu. Ph.D.)                                     

醫技研究所 教授 分機:5795   Email: tffu@mail.ncku.edu.tw

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490-1.php#tabs|Teacher:1

專長與研究興趣:

  1. 維生素B6相關之斑馬魚疾病模式(如:癲癇)
  2. 維生素B9(葉酸)相關之斑馬魚疾病模式(如:胎兒脊神經管閉鎖不全症、阿茲海默症等)
  3. 斑馬魚神經功能及行為模式分析
  4. 斑馬魚為活體平台進行相關藥物篩選
  5. 斑馬魚癌症模式之建立與應用

近五年代表作:

  1. Kao TT, Chu CY, Lee GH, Hsiao TH, Cheng NW, Chang NS, Chen BH and Fu TF* (2014, Aug). Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish-Implication in neural tube defects and Alzheimer’s diseases. Neurobiology of Disease, 71: 234-244
  2. Chang WN, Lee GH, Kao TT, Lin CY, Hsiao TH, Tsai JN, Chen BH, Chen YH, Wu HR, Tsai HJ, Fu TF* (2014, Apr). Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Biochim Biophys Acta. 1840(7):2340-2350
  3. Fu YC; Fu TF; Wang HJ; Lin CW; Lee GH; Wu SC; Wang CK* (2014, July). Aspartic acid based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluations. Acta Biomaterialia, (Accepted)
  4. Hsiao TH, Lin CJ, Chung YS, Lee GH, Kao TT, Chang WN, Chen BH, Hung JJ, Fu TF*. (2014, Feb). Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. Mol Cell Biol., 34(3):498-509.
  5. Yang WB1, Chen PH, Hsu T 1st, Fu TF, Su WC, Liaw H, Chang WC, Hung JJ* (2014, Feb). Sp1-mediated microRNA-182 expression regulates lung cancer progression. Oncotarget. 15:740-53.
  6. Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF*, Chen CJ*. (2013, Oct). Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish γ-glutamyl hydrolase.. J Med Chem. 56(19):7625-35.
  7. Kao TT, Lee GH, Fu CC, Chen BH, Chen LT, Fu TF*. (2013, Sep). Methotrexate-induced decrease in embryonic 5-methyl-tetrahydrofolate is irreversible with leucovorin supplementation. Zebrafish, 10(3):326-37.
  8. Lee GH, Sung SY, Chang WN, Kao TT, Du HC, Hsiao TH, Safo MK, Fu TF* (2012, Nov). Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. Disease Models & Mechanisms, 5. 785-95.
  9. Chen BH*, Hung MH, Chen YF, Chang HW, Yu ML, Wan L, Tsai FJ, Wang TP, Fu TF, Chiu CC* (2012, May) Anti-allergic activity of grape seed extract (GSE) on RBL-2H3 mast cells. Food Chem.12, 968-974
  10. Chuang YC, Lei HY, Liu HS, Lin YS, Fu TF, Yeh TM* (2011, May). Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability. Cytokine. 54(2):222-31
  11. Lin CJ, Hsiao TH, Chung YS, Chang WN, Yeh TM, Chen BH, Fu TF*. (2011, Mar). Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1. Protein Expr Purif. 76(1):36-43
  12. Kao TT, Tu HC, Chang WN, Chen BH, Shi YY, Chang TC, Fu TF* (2010, Jun) “Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism” International Journal of Food Microbiology, 141, 17-27
  13. Chang WN, Lin HC, Fu TF* (2010, Aug) “Zebrafish 10-Formyltetrahydrofolate Dehydrogenase is similar to its mammalian isozymes for its structural and catalytic properties” Protein Expression and Purification, 72, 217-222
  14. Chen BH, Wu PY, Chen KM, Fu TF, Wang HM, Chen CY. (2009, May) Antiallergic Potential on RBL-2H3 Cells of Some Phenolic Constituents of Zingiber officinale (Ginger), Journal of Natural Products, 72(5):950-3
  15. Kao TT, Chang WN, Wu HL, Shi GY, Fu TF*. (2009, Feb) Recombinant zebrafish γ–glutamyl hydrolase exhibits comparable properties and catalytic activities to mammalian enzyme, Drug Metabolism and Disposition, 37, 302-309