傅子芳

傅子芳 (Tzu-Fun Fu. Ph.D.)                                     

醫技研究所 教授 分機:5795   Email: tffu@mail.ncku.edu.tw

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

專長與研究興趣:

 

  1. 維生素B的生理與病理作用機轉、斑馬魚疾病模式的建立
  2. 斑馬魚神經功能及行為模式分析
  3. 以斑馬魚為活體平台進行相關藥物篩選
  4. 斑馬魚癌症模式之建立與應用

 

近五年代表作:

 

  1. Tu HC, Lee GH, Hsiao TH, Kao TT, Wang TY, Tsai JN, Fu TF*. (2017 Nov) One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae. PLoS One.
  2. Chang WN, Chi WY, Kao TT, Tsai JN, Liu W, Liang SS, Chiu CC, Chen BH, Fu TF*. (2017 Jun) The Transgenic Zebrafish Display Fluorescence Reflecting the Expressional Dynamics of Dihydrofolate Reductase. Zebrafish.
  3. Chiu CC, Chou HL, Chen BH, Chang KF, Tseng CH, Fong Y, Fu TF, Chang HW, Wu CY, Tsai EM, Lin SR, Chen YL*. (2015) BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model. BMC Cancer. 2015 Dec 16
  4. Sze CI, Kuo YM, Hsu LJ, Fu TF, Chiang MF, Chang JY, Chang NS*. (2015) A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency. Cell Death Dis. 2015 Sep 10
  5. Lin CC, Chuankhayan.P, Chang WN, Kao TT, Guan HH, Fun HK, Nakagawa.A, Fu TF*, Chen CJ*. (2015). Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition. Acta Crystallogr D, 71: 1006-1021.
  6. Kao TT, Chu CY, Lee GH, Hsiao TH, Cheng NW, Chang NS, Chen BH and Fu TF* (2014, Aug). Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish-Implication in neural tube defects and Alzheimer’s diseases. Neurobiology of Disease, 71: 234-244
  7. Chang WN, Lee GH, Kao TT, Lin CY, Hsiao TH, Tsai JN, Chen BH, Chen YH, Wu HR, Tsai HJ, Fu TF* (2014, Apr). Knocking down 10-formyltetrahydrofolate dehydrogenase increased oxidative stress and impeded zebrafish embryogenesis by obstructing morphogenetic movement. Biochim Biophys Acta. 1840(7):2340-2350
  8. Fu YC; Fu TF; Wang HJ; Lin CW; Lee GH; Wu SC; Wang CK* (2014, July). Aspartic acid based modified PLGA-PEG nanoparticles for bone targeting: in vitro and in vivo evaluations. Acta Biomaterialia, (Accepted)
  9. Hsiao TH, Lin CJ, Chung YS, Lee GH, Kao TT, Chang WN, Chen BH, Hung JJ, Fu TF*. (2014, Feb). Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress. Mol Cell Biol., 34(3):498-509.
  10. Yang WB1, Chen PH, Hsu T 1st, Fu TF, Su WC, Liaw H, Chang WC, Hung JJ* (2014, Feb). Sp1-mediated microRNA-182 expression regulates lung cancer progression. Oncotarget. 15:740-53.
  11. Chuankhayan P, Kao TT, Lin CC, Guan HH, Nakagawa A, Fu TF*, Chen CJ*. (2013, Oct). Structural insights into the hydrolysis and polymorphism of methotrexate polyglutamate by zebrafish γ-glutamyl hydrolase.. J Med Chem. 56(19):7625-35.
  12. Kao TT, Lee GH, Fu CC, Chen BH, Chen LT, Fu TF*. (2013, Sep). Methotrexate-induced decrease in embryonic 5-methyl-tetrahydrofolate is irreversible with leucovorin supplementation. Zebrafish, 10(3):326-37.
  13. Lee GH, Sung SY, Chang WN, Kao TT, Du HC, Hsiao TH, Safo MK, Fu TF* (2012, Nov). Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. Disease Models & Mechanisms, 5. 785-95.