首頁師資〉教師指導學生

吳俊忠

吳俊忠(Wu, Jiunn-Jong, Ph.D.)

醫技所 教授   

分機:56055775    E-mail: jjwu@mail.ncku.edu.tw

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

 

研究興趣

 

1.    A群鏈球菌致病機轉之探討:A群鏈球菌可能的致病因子有許多,其中由本實驗室研究結果顯示蛋白水解(cysteine protease)活性與臨床症狀以及毒力因子有顯著的相關性;此外也發現oligopeptide permease A群鏈球菌之毒力因子有顯著的相關性。目前針對此基因及蛋白深入探討其致病機轉及基因調控。

2.   細菌抗藥性之研究:台灣的細菌抗藥性相當嚴重,本實驗室針對革蘭氏陰性細菌b-lactamase的產生以及革蘭氏陽性球菌對Marcolides 之抗性,進一步深入探討其機制。

3.    幽門螺旋桿菌致病機轉之探討:幽門螺旋桿菌的感染常與胃的疾病有關,本實驗室與腸胃科醫師共同合作探討此菌之致病因子,特別是附著基因在體外及動物感染之研究。

 

近五年代表作

 

  1. Sheu SM, Hung KH, Sheu BS, Yang HB and Wu JJ*. 2009 Jan. Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan. Journal of Clinical Microbiology 47(1):249-251
  2. Hung KH, Sheu BS, Chang WL, Wu HM, Liu CC, and Wu JJ*. 2009 Feb. Prevalence of primary fluoroquinolone resistance among clinical isolates of Helicobacter pylori at a university hospital in southern Taiwan. Helicobacter 14:61-65
  3. Sheu SM, Sheu BS, Lu CC, Yang HB and Wu JJ*. 2009 Mar. Mixed infections of Helicobacter pylori: tissue tropism and histological significance. Clinical Microbiology and Infection. 15(3):253-259.
  4. Chiang-Ni C, Zeng PX, Ho YR, Wu HM, Chuang WJ, Lin YS, Lin MT, Liu CC, and Wu JJ*. 2009 Oct. emm1/sequence type 28 strains of group A streptococci that express covR at early-stationary phase are associated with increased growth and earlier SpeB secretion. Journal of Clinical Microbiology 47 (10): 3161-3169.
  5. Tsou CC, Chiang-Ni C, Lin YS, Chuang WJ, Lin MT, Liu CC, and Wu JJ*. 2010.  Oxidative stress and metal ions regulate a ferritin-like gene, dpr, in Streptococcus pyogenes. International Journal of Medical Microbiology [Epub ahead of print].
  6. Liu YF, Yan JJ, Lei HY, Teng CH, Wang MC, Tseng CC, Wu JJ*. (2012) Loss of outer membrane protein C in Escherichia coli contributes both to antibotic resistance and escaping antibody-dependent bactericidal activity. Infect Immun, 80(5):1815-22.
  7. Kao CY, Sheu BS, Sheu SM, Yang HB, Chang WL, Cheng HC, Wu JJ*. (2012) Higher motility enhances bacterial density and inflammatory response in dyspeptic patients infected with Helicobacter pylori. Helicobacter.  17:411-416.
  8. Kao CY, Sheu SM, Sheu BS, Wu JJ*.(2012) Length of thymidine homopolymeric repeats modulates promoter activity of sabA in Helicobacter pylori. Helicobacter. 17:203-209.
  9. Sheu SM, Sheu BS* , Chiang WC, Kao CY, Wu HM, Yang HB, Wu JJ*. (2012)H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes. BMC Microbiol 30;12:89.