首頁師資〉專/兼任師資專長

王貞仁

王貞仁  (Jen-Ren Wang, Ph. D.)

醫技所 教授    分機:5786, 5785         E-mail:jrwang@mail.ncku.edu.tw

http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

研究興趣

Viral pathogenesis, virus-host cell interaction, diagnostic virology, epidemiology of enteroviruses, influenza and dengue viruses, virulence gene analysis of enterovirus A71, influenza and dengue viruses, antigenicity and vaccine development.

近五年代表作

  1. Tsai YH, HuangSW, Hsieh WS, Cheng CK, Chang CF, Wang JR. VP1 codon-deoptimization and high-fidelity polymerase reverse genetics virus as next generation enterovirus A71 as vaccine candidate. J Virol (accept).
  2. Huang SW, Hung SJ, Wang JR. 2019. Application of deep sequencing methods for inferring viral population diversity. J Virol Methods 266: 95-102, 2019.
  3. Huang SW, Huang YH, Tsai HP, Kuo PH, Wang SM, Liu CC, Wang JR. 2017. A selective bottleneck shapes the evolutionary mutant spectra of enterovirus A71 during viral dissemination in humans. J Virol 91 (23).
  4. Tsai HP, Tsai YY, Lin IT, Kuo PH, Chen TY, Chang KC, Wang JR.2016. Comparison of two commercial automated nucleic acid extraction and integrated quantitation Real-Time PCR platforms for the detection of cytomegalovirus in plasma. PLoS One. 2016 Aug 5;11(8):e0160493. doi: 10.1371/journal.pone.0160493.
  5. Tsai HP, Tsai YY, Lin IT, Kuo PH, Chang KC, Chen JC, Ko WC, Wang JR.2016. Validation and application of a commercial quantitative real-time reverse transcriptase-PCR Assay in investigation of a large dengue virus outbreak in southern Taiwan. PLOS Negl Trop Dis 2016 Oct 12;10(10):e0005036.
  6. Huang SW, Tai CH, Fonville JM, Lin CH, Wang SM, Liu CC, Su IJ, Smith DJ, Wang JR. 2015. Mapping enterovirus A71 antigenic determinants from viral evolution. J Virol Nov 15;89(22):11500-6.
  7. Huang SW, Cheng HL, Hsieh HY, Chang CL, Tsai HP, Kuo PH, Wang SM, Liu CC, Su IJ, Wang JR. 2014. Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71. J Biomed Sci. 21:33. doi: 10.1186/1423-0127-21-33.
  8. Huang SW, Wang YF, Yu CK, Su IJ, Wang JR. 2012. Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology 422:132-143.