首頁師資〉教師指導學生

郭余民

郭余民Yu-Min Kuo, Ph.D.

解剖學科暨細胞生物與解剖學研究所 教授 

分機:5294    E-mail: kuoym@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~anatomy/

 

研究興趣 

Neurodegenerative diseases: 1) Pathophysiology; 2) Biomarker; 3)Treatment strategy

Exercise & brain functions:1) Neuroinflammation; 2) Synaptic plasticity;3) Neuroprotection; 4) Aging

近五年代表作: 

  1. Yang TT, Lin C, Hsu CT, Wang TF, Ke FY, Kuo YM*. (2013) Differential distribution and activation of microglia in the brain of male C57BL/6J mice. Brain Struct Funct. 218:1051-60.
  2. Lee CW, Shih YS, Kuo YM*. (2014) Cerebrovascular pathology and amyloid plaque formation in Alzheimer’s disease. Curr Alzheimer Res. 11:4-10.
  3. Tsai SF, Huang TY, Chang CY, Hsu YC, Chen SJ, Yu L, Kuo YM*, Jen CJ*. (2014) Social instability stress differentially affects amygdalar neuron adaptations and memory performance in adolescent and adult rats. Front Behav Neurosci. 3:8:27.
  4. Shih YS, Tsai KJ, Lee CW, Shiesh SC, Chen WT, Pai MC*, Kuo YM*. (2014) Apolipoprotein C-III is an Aβ-binding protein and an early marker for Alzheimer's disease. J Alzheimer Dis 41:855-865.
  5. Lin TW, Shih YH, Chen SJ, Lien CH, Chang CY, Huang TY, Chen SH, Jen CJ, Kuo YM*. (2015) Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice. Neurobiol Learn Memory 118:189-197.
  6. Yang TT, Lo CP, Tsai PS, Wu SY, Wang TF, Chen YW, Jiang-Shieh YF, Kuo YM*. (2015) Aging and exercise affect hippocampal neurogenesis via different mechanisms. PLoS ONE 10(7): e0132152.
  7. Lin TW, Liu YF, Shih YH, Chen SJ, Huang TY, Chang CY, Lien CH, Yu L, Chen SH, Kuo YM*. (2015) Neurodegeneration in amygdala precedes hippocampus in the APPswe/PS1dE9 mouse model of Alzheimer’s disease. Curr Alzheimer Res 12:951-963.
  8. Shih YH, Tsai SF, Huang SH, Chiang YT, Hughes MW, Wu SY, Lee CW, Yang TT, Kuo YM*. (2016) Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory. Neuroscience. 322:346-357
  9. Wu SY, Chen YW, Tsai SF, Wu SN, Shih YH, Jiang-Shieh YF, Yang TT, Kuo YM*. (2016, March) Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel. Sci Reports 6, 22864
  10. Tsai SF, Chen PC, Calkins MJ, Wu SY, Kuo YM*. (2016) Exercise counteracts aging-related memory impairment: a potential role for the astrocytic metabolic shuttle. Front Aging Neurosci 8,57.
  11. Lee MH, Shih YH, Lin SR, Chang JY, Lin YH, Sze CI*, Kuo YM*, Chang NS*. (2017) Zfra restores memory deficits in Alzheimer’s disease triple transgenic mice by blocking aggregation of TRAPPC6A, SH3GLB2, tau and amyloid beta and inflammatory NF-κB activation. Alzheimers Dement 3:189-204.
  12. Shih YH, Wu SY, Yu M, Huang SH, Lee CW, Jiang MJ, Lin PY, Yang TT, Kuo YM*. (2018) Hypertension accelerates Alzheimer’s disease-related pathologies in pigs and 3xTg mice. Front Aging Neurosci 10:73.