首頁師資〉教師指導學生

郭余民

郭余民Yu-Min Kuo, Ph.D.

解剖學科暨細胞生物與解剖學研究所 教授  

分機:5294    E-mail: kuoym@mail.ncku.edu.tw

 

研究興趣 

l   Alzheimer’s diseases: 1) Pathophysiology; 2) Biomarker; 3)Treatment strategy

l   Exercise & brain function:1) Neuroinflammation; 2) Autonomic system

l   Interaction between metabolic disorders and mood disorders

近五年代表作: 

 

  1. Shih YH, Tsai SF, Huang SH, Chiang YT, Hughes MW, Wu SY, Lee CW, Yang TT, Kuo YM*. (2016) Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory. Neuroscience. 322:346-357
  2. Wu SY, Chen YW, Tsai SF, Wu SN, Shih YH, Jiang-Shieh YF, Yang TT, Kuo YM*. (2016, March) Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel. Sci Reports 6, 22864
  3. Tsai SF, Chen PC, Calkins MJ, Wu SY, Kuo YM*. (2016) Exercise counteracts aging-related memory impairment: a potential role for the astrocytic metabolic shuttle. Front Aging Neurosci 8,57.
  4. Lee MH, Shih YH, Lin SR, Chang JY, Lin YH, Sze CI*, Kuo YM*, Chang NS*. (2017) Zfra restores memory deficits in Alzheimer’s disease triple transgenic mice by blocking aggregation of TRAPPC6A, SH3GLB2, tau and amyloid beta and inflammatory NF-κB activation. Alzheimers Dement 3:189-204.
  5. Shih YH, Wu SY, Yu M, Huang SH, Lee CW, Jiang MJ, Lin PY, Yang TT, Kuo YM*. (2018) Hypertension accelerates Alzheimer’s disease-related pathologies in pigs and 3xTg mice. Front Aging Neurosci 10:73.
  6. Tsai SF, Ku NW, Wang TF, Yang YH, Shih YH, Wu SY, Lee CW, Yu M, Yang TT, Kuo YM*. (2018) Long-term moderate exercise rescues age-related decline in hippocampal neuronal complexity and memory. Gerontology 64:551-561.
  7. Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Tzeng SF, Wu PH, Chen PS, Kuo YM*. (2018) Stress aggravates high-fat diet-induced insulin resistance via a mechanism that involves the amygdala and is associated with changes in neuroplasticity. Neuroendocrinology 107(2):147-157.
  8. Tsai SF, Wu HT, Chen PC, Chen YW, Yu M, Wang TF, Wu SY, Tzeng SF, Kuo YM*. (2018) High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice. Brain Research 1700: 66-77.
  9. Lin TW, Tsai SF, Kuo YM*. (2018) Physical exercise enhances neuroplasticity and delays Alzheimer's disease. Brain Plasticity 4(1):95-110.
  10. Tsai SF, Liu YW, Kuo YM*. (2019) Acute and long-term treadmill running differentially induce c-Fos expression in regions- and time-dependent manners in mouse brain. Brain Structure & Function, 224(8), 2677-2689.
  11. Mee-inta O, Zhao ZW, Kuo YM*. (2019) Physical exercise inhibits inflammation and microglial activation. Cells, 8(7), 691.