首頁師資〉教師指導學生

王憲威

王憲威 (Shainn-Wei Wang. Ph.D.)                           

分子醫學研究所 副教授 分機:4218, 4217   Email: swwang@mail.ncku.edu.tw

個人網址:http://imm.med.ncku.edu.tw/c_website/faculty/Faculty_chinese/sw_c.htm

專長與研究興趣:

免疫學(DNA疫苗,黏膜與細胞免疫),高等病毒學(反轉錄病毒; 病毒重組與出芽機制),細胞生化學(蛋白交互作用; 蛋白生化與胞膜訊息),分子遺傳學(核酸轉錄與轉訊調控)

病毒組裝需要病毒蛋白與寄主細胞的交互協調作用,這個進程也伴隨著病毒基因的專一性嵌入而形成具感染性的生物體。是什麼機制造成病毒結構蛋白的組裝呢?寄主細胞內有哪些蛋白可被病毒蛋白霸佔借用於病毒組裝及感染呢?又有哪些病毒蛋白可與寄主細胞蛋白互通款曲欺騙寄主的免疫防衛系統呢? 我們能暸知並利用這些交互作用的機制進而發展抗病毒藥物或疫苗嗎?這些是我實驗室最基本的科學研究訴求。我目前的研究方向在瞭解(1)HIV的藥物抗性與流行性病毒學 (2) HIV,HCV,及流感病毒之宿主交互作用與致病機制:利用蛋白質體學找出對抗或幫助病毒繁殖或致病的寄主蛋白因子,以做治療性疫苗開發。我目前進行的實驗計畫有(1) 南台灣HIV抗性的監測與診測試劑研發 (3)愛滋病疫苗發展與粘膜免疫。(4)確認愛滋病病毒的結構蛋白Gag在細胞運輸時,與核酸鞘蛋白(Nucleocapsid)有交互作用的寄主蛋白網路。(5)蛋白質體學運用與分析C型肝炎病毒(HCV)核蛋白(Core)在肝細胞及免疫細胞內作用的蛋白網路。(6)流感病毒NEP蛋白與宿主蛋白之交互作用網路。(7)腸病毒(EV71)結構蛋白的宿主蛋白交互作用喻致病機制。

近五年代表作

  1. Manrique M, Kozlowski PA, Cobo-Molinos A, Wang SW, Wilson RL, Martinez-Viedma Mdel P, Montefiori DC, Carville A, Aldovini A. Resistance to infection, early and persistent suppression of simian immunodeficiency virus SIVmac251 viremia, and significant reduction of tissue viral burden after mucosal vaccination in female rhesus macaques. J Virol. 2014 Jan;88(1):212-24.
  2. Lai MC, Wang SW, Cheng L, Tarn WY, Tsai SJ, Sun HS. Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PloS One, 2013 Jul; 8(7):e68665.
  3. Shen FH, Wang SW, Yeh TM, Tung YY, Hsu SM, Chen SH. Absence of CXCL10 aggravates Herpes Stromal Keratitis with reduced primary neutrophil influx in mice. J. Virol. 2013 Aug, 87(15):8502-10..
  4. Wang JH, Cheng L, Wang CH, Ling W, Wang SW*, and Lee GB*. An integrated chip capable of performing sample pretreatment and nucleic acid amplification for HIV-1 detection. Biosensors & Bioelectronics. 2013 Mar 15, 41:484-91.
  5. Sun HY, Lin CC, Lee JC, Wang SW, Cheng PN, Wu IC, Chang TT, Lai MD, Shieh DB, Young KC. Very low-density lipoprotein/lipo-viro particles reverse lipoprotein lipase-mediated inhibition of hepatitis C virus infection via apolipoprotein C-III. Gut, 2012 Aug;62(8):1193-203..
  6. Yeh MT, Wang SW, Yu CK, Lin KH, Lei HY, Su IJ, Wang JR. A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice. PLoS one. 2011; 6(11):e27082..
  7. Lee JW, Liao PC, Young KC, Chen SL, Chang CL, Cheng TS, Lai MD, Wang SW*. Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. Journal of Proteome Research, 2011 Oct 7; 10(10):4522-34.
  8. Yang ML, Chen YH, Wang SW, Huang YJ, Leu CH, Yeh NC, Chu CY, Lin CC, Shieh GS, Chen YL, Wang JR, Wang CH, Wu CL, Shiau AL. Galectin-1 binds to influenza virus and ameliorates influenza pathogenesis. J. Virol. 2011 Oct, 85(19):10010-20..
  9. Ko NY, Lee HC, Hung CC, Tseng FC, Chang JL, Lee NY, Chang CM, Lee MP, Chen BJ, Wang SW*, Ko WC. Trends of HIV and Sexually Transmitted Infections, Estimated HIV Incidence, and Risky Sexual Behaviors Among Gay Bathhouse Attendees in Taiwan: 2004-2008. AIDS Behav. 2011 Feb 8, 15(2):292-7.