首頁師資〉教師指導學生

楊倍昌

楊倍昌  Yang, Bei-Chang, Dr. rer. nat. (Doktor der Naturwissenschaft)

微免所 教授  

分機:5637    E-mail: y1357@mail.ncku.edu.tw

個人網址:http://myweb.ncku.edu.tw/~y1357/yang.html  

 

研究興趣 

 

  1. Tumor specific extracellular matrix (integrin/disintegrin):腫瘤微環境對免疫細胞的影響。免疫細胞受到刺激後轉移進入受傷/感染組織是啟動免疫反應最早期的反應。細胞間質extracellular matrix (ECM)會刺激免疫細胞上的integrin 而影響細胞的移動。如果免疫細胞徵召的過程不當常常會導致免疫反應不足,或是引起病態性的發炎,反而使器官受到損壞。免疫細胞會延著chemokine的濃度而爬行到發炎組織。我們將研究細胞間質影響腫瘤浸潤細胞移動的分子機轉。
  2. Imaging of cell migration:T 細胞的移動是免疫反應重要的基礎。Zap70 能決定T 細胞移動的方向性。我們透過錄影工具來追蹤T 細胞移動的過程中,Zap70、Talin與actin filament等等分子在細胞偽足前緣的互動。

 

近五年代表作(corresponding author)

  1. Su CC, Lin HC, Lin YP, Shan YS, and Yang BC (2013) Expression of Th17-related genes in PHA/IL-2-activated human T cells by Fas signaling via caspase-1- and Stat3-dependent pathway. Cell Immunol. 281:101–110.
  2. Lin HC, Lai PY, Lin YP, Su CC, Huang JY, and Yang BC (2012) Fas ligand enhances the malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 287:20664–20673.
  3. Hwang JY, Cheng YJ, Lin YP, Lin HC, Su CC, Juliano R, and Yang BC (2010) Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: a role of tenascin-C in immune suppression. J Immunol. 185:1450-1459.
  4. Lin YP, Cheng YJ, Huang JY, Lin HC, and Yang BC (2010) Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T cell migration. Mol Immunol. 47(11-12):2022-9.
  5. Lin YP, Su CC, Hwang JY, Lin HC, Cheng YJ, Liu MF, and Yang BC (2009) Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis. Mol Immunol. 2009, 46(16):3328-35.
  6. Cheng YJ, Lee CH, Lin YP, Hwang JY, Su CC, Chang WT, and Yang BC (2008) Caspase-3 enhances lung metastasis and cell migration in a protease-independent mechanism through ERK pathway. Int J Cancer 123:1278-1285.