首頁師資〉教師指導學生

陳舜華

陳舜華  (Chen, Shun-Hua, Ph.D.)

微免所 教授 

分機5633    E-mail: shunhua@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/%7Emicrobio/teacher/ccsh.htm

 

研究興趣 

病毒感染引起人類許多疾病,嚴重者甚至造成死亡。想要有效的治療、預防及控制病毒感染引起的疾病,首先必須瞭解病毒的致病機制。我實驗室的研究以動物模型來探討病毒致病機制,應用分子病毒學的方法,找出病毒致病的基因,並深入探討其機轉。同時也研究病毒感染後與寄主的互動,引起的免疫反應有那些,及這些免疫反應在感染過程中扮演的角色。期望能提供訊息,幫助臨床醫師更有效的治療、預防及控制病毒感染引起的疾病。目前實驗室研究神經性病毒之如庖疹病毒及腸病毒七十一型的致病機轉。

近五年代表作

  1. Shen FH, Wang SW, Yeh TM, Tung YY, Hsu SM, and Chen SH (2013) Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice. J. Virol. 87: 8502-8510.
  2. Yao HW, Lin PH, Shen FH, Perng GC, Tung YY, Hsu SM, and Chen SH (2014) Tranylcypromine reduces herpes simplex virus 1 infection in mice. Antimicrob. Agents Chemother. 58: 2807-2815. 
  3. Yao HW, Ling P, Tung YY, Hsu SM, and Chen SH (2014) In vivo reactivation of latent herpes simplex virus 1 in mice can occur in the brain before in the trigeminal ganglion. J. Virol. 88: 11264-11270.
  4. Shen FH, Tsai CC, Wang LC, Chang KC, Tung YY, Su IJ and Chen SH (2013) Enterovirus 71 infection increases expression of interferon-gamma-inducible protein 10 which protects mice by recruiting lymphocytes to reduce viral burden in multiple organs. J. Gen. Virol. 94: 1019-1027.
  5. Shen FH, Shen TJ, Chang TM, Su IJ, and Chen SH (2014) Early dexamethasone treatment exacerbates enterovirus 71 infection in mice. Virology 464-465: 218–227.
  6. Wang LC, Chen SO, Chang SP, Lee TP, Yu CK, Chen CL, Tseng PC, Hsieh CY, Chen SH (correspondence), and Lin CF. (2015) Enterovirus 71 proteins 2A and 3D antagonize the antiviral activity of IFN-γ via signaling attenuation J. Virol. 89:7028-7037.
  7. Huang CY, Yao HW, Wang LC, Shen FH, Hsu SM, and Chen SH (2017) Thymidine kinase-negative herpes simplex virus 1 can efficiently establish persistent infection in neural tissues of nude mice. J. Virol. 91 (4):  e01979-16
  8. Wang LC, Yao HW, Chang CF, Wang SW, Wang SM, Chen SH (2017) Suppression of interleukin-6 increases enterovirus A71 lethality in mice. J. Biomed. Sci. 24:94  DOI 10.1186/s12929-017-0401-5