首頁師資〉教師指導學生

林以行

林以行  (Lin, Yee-Shin, Ph.D.)

微免所 教授分機:5646   E-mail: yslin1@mail.ncku.edu.tw 

研究興趣

  1. 登革病毒致病機制及抗病毒策略和疫苗研發。
  2. A群鏈球菌感染之致病機轉及抗發炎藥物之保護作用。
  3. 細胞凋亡和細胞自噬機制及訊息傳遞。 

近五年代表作

  1. Chu, Y. T., S. W. Wan,Y. C. Chang,C. K. Lee, B. A. Wu-Hsieh, R. Anderson,and Y. S. Lin. 2017. Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation. Lab. Invest. doi: 10.1038/labinvest.2017.10. [Epub ahead of print]
  2. Zainal, N., C. P. Chang, Y. L. Cheng, Y. W. Wu, R. Anderson, S. W. Wan,C. L. Chen, T. S. Ho, S. AbuBakar, and Y. S. Lin. 2017. Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection. Sci. Rep.7:42998.
  3. Chen, Y. D., Y. T. Fang, C. P. Chang,C. F. Lin, L. J. Hsu, S. R. Wu, Y. C. Chiu, R. Anderson, and Y. S. Lin. 2017. S100A10 regulates ULK1 localization to ER-mitochondria contact sites in IFN-g-triggered autophagy. J. Mol. Biol. 429:142-157.
  4. Wu, Y. W., C. Mettling, S. R. Wu, C. Y. Yu, G. C. Perng, Y. S. Lin, and Y. L. Lin. 2016. Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Sci. Rep. 6:32243.
  5. Wan, S. W.,Y. W. Yang, Y. T. Chu, C. F. Lin, C. P. Chang, T. M. Yeh, R. Anderson, and Y. S. Lin. 2016. Anti-dengue virus nonstructural protein 1 antibodies contribute to platelet phagocytosis by macrophages. Thromb. Haemost. 115:646-656.
  6. Chen, C. L., Y. Y. Wu, C. F. Lin,C. F. Kuo,C. L. Han, S. Wang, W. J. Chuang, C. Y. Chen, J. J. Wu,P. J. Tsai, C. C. Liu, and Y. S. Lin. 2016. Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage. Sci. Rep. 6:26026.
  7. Lu, S. L., C. F. Kuo, H. W. Chen, Y. S. Yang, C. C. Liu, R. Anderson, J. J. Wu, and Y. S. Lin. 2015. Insufficient acidification of autophagosomes facilitates group A streptococcus survival and growth in endothelial cells. mBio 6:e01435-15.
  8. Wan, S. W., Y. T. Lu, C. H. Huang, C. F. Lin, H. S. Liu, T. M. Yeh, R. Anderson, Y. T. Yen, B. A. Wu-Hsieh, andY. S. Lin. 2014. Protection against dengue virus infection in mice by administration of antibodies against modified nonstructural protein 1. PLoS One 9:e92495.
  9. Chen, C. L., C. F. Lin, S. W. Wan, L. S. Wei, M. C. Chen, T. M. Yeh, H. S. Liu, R. Anderson, and Y. S. Lin. 2013. Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated GSK-3βand NF-κB activation. J. Immunol. 191:1744-1752.
  10. Lu, S. L., C. F. Kuo, W. C. Lin, Y. T. Chang, J. J. Wu, W. J. Chuang, C. C. Liu, L. Chao, J. Chao, and Y. S. Lin. 2013. Kallistatin modulates immune cells and confers anti-inflammatory response to protect mice from group A streptococcal infection.Antimicrob. Agent. Chemother. 57:5366-5372.