首頁師資〉專/兼任師資專長

蔡少正

蔡少正  (Shaw-Jenq Tsai, Ph.D.)

生理學科暨生理所 教授兼任所長 

分機:5426    E-mail: seantsai@mail.ncku.edu.tw

個人網址:http://phys.med.ncku.edu.tw/fac-seantsai.php 

研究興趣

本實驗室主要有三個研究方向。一、缺氧誘導因子(HIF-1α)調控基因與癌症抗藥性之研究。細胞因為缺氧會產生種種不同的生理反應或病理變化,包括學習記憶、癌症、心血管疾病、生長遲緩、腦部疾病、肺部疾病等。我們利用生物資訊學的方法,將基因體中會受缺氧誘導因子調控之基因(包括人類、大鼠、小鼠)找尋出來,並研究其在生理、病理上的功能,尤其著重在癌症抗藥性方面的探討,目前以大腸癌及胰臟癌的抗藥性機制為重點;二、研究整個基因體的調控(Gene regulatory network)及細胞分化、去分化及再分化的機轉。表觀基因體調控(epigenomic modification and reprograming)對細胞之命運影響至巨,甚或造成細胞病變。我們利用生物資訊學、功能性基因體學、系統生物學等尖端方法,對此一現象作深入的研究;三、探討子宮內膜異位(endometriosis)成因之分子機制,子宮內膜異位症約佔生殖年齡期婦女人數的10-15%,大部分會導致不孕症的發生,目前有關子宮內膜異位形成之原因,並不清楚。本實驗室過去幾年的研究,在這個領域已有相當不錯的成果,未來將著重在整合性基因功能上的研究。

近五年代表作

    1. SC Lin, YH Li, MH Wu, YF Chang, DK Lee, S Tsai, MJ Tsai, and SJ Tsai* 2014 Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab 99(3): E427-37
    2. TM Chen, YH Shih, JT Tseng, MC Lai, Ch Wu, YH Li, SJ Tsai*, and HS Sun* 2014 Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res 42:2932-44
    3. MH Wu, PC Chuang, YJ Lin, SJ Tsai* 2013 Suppression of annexin A2 by prostaglandin E2 impairs phagocytic ability of peritoneal macrophage in women with endometriosis. Hum Reprod 28:1045-53
    4. J Qin, SP Wu, F Dai, X Xie, CM Cheng, C J Creighton, A Frolov, Gustavo Ayala4, X Lin, XH Feng, MM Ittmann, SJ Tsai, MJ Tsai, S Y Tsai 2013 Inhibition of TGF-β-dependent growth barrier by COUP-TFII to promote prostate tumor growth and metastasis. Nature 493: 236-240
    5. SP Wu, CM Cheng, W Chen, T Wang, JL Respress, S Ather, RB Lanz, SJ Tsai, XHT Wehrens, MJ Tsai, and S Y Tsai 2013 Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell25, 417–426
    6. SC Lin, CC Wang, MH Wu, HS Yang, YH Lee, SJ Tsai*. 2012 Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab, 97: E1515–E1523.
    7. Lin SC, Chien CW, Lee JC, YehYC, Hsu KF, Lai YY, Lin SC, and Tsai SJ* 2011 Suppression of dual specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells.J Clin Invest 121: 1905-1916
    8. MH Wu, SC Lin, KY Hsiao, and SJ Tsai* 2011 Hypoxia-inhibited dual specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol 225: 390-400
    9. CW Lu, SC Lin, CW Chien, SC Lin, CT Lee, BW Lin, JC Lee, and SJ Tsai* 2011 Overexpression of pyruvate dehydrogenase kinase-3 increases drug resistance and predicts poor prognosis of colon cancer. Am J Pathol 179: 1405-11
    10. Wang HC, Chen YS, Kao HY, Tsai SJ* 2011 Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics 27:1422-1428
    11. Chen TM, Hsu CH, Tsai SJ*, Sun HS* 2010 AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res 38:8061-8071
    12. ChuangPC, Lin YJ, Wu MH, Wing LYC, Shoji Y, and Tsai SJ* 2010 Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol 176:850-860