首頁師資〉教師指導學生

莊季瑛

莊季瑛  (Chuang, Jih-Ing, Ph.D.)

生理所 教授 

分機:5460    E-mail: jichuang@mail.ncku.edu.tw

個人網址:http://phys.med.ncku.edu.tw/fac-chuang.php 

 

研究興趣

 

  1. 以動物和細胞培養模式,探討神經滋養因子和抗氧化劑的神經保護作用機轉和相互關係。
  2. 探討粒線體損傷在神經退化性疾病中以及褪黑激素的保護作用機轉所扮演的角色。
  3. 利用許多神經退化性疾病的動物和細胞培養模式(如:腦缺血、腦創傷和巴金森氏症等),尋找具有保護神經細胞作用的藥物,以利於治療或預防神經退化性疾病的藥物研發。

近五年代表作 

 

  1. Tsai MC, Chen WJ, Ching CH, Chuang JI*. (2007)  Resuscitation with hydroxyethyl starch solution prevents NF-kappa B activation and oxidative stress after hemorrhagic shock and resuscitation in rats. Shock, 27:527-533.

 

  1. Lin CH, Huang JY, Ching CH andChuang JI*.(2008)  Melatonin reduces the neuronal loss, down regulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. J. Pineal Res.,44:205-213.

 

  1. Huang JY, Hong YT, Chuang JI*. (2009)  Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J. Neurochem. 109:1400-1412.

 

  1. Huang JY, Chuang JI*. (2010)  Fibroblast growth factor 9 upregulates heme oxygenase-1 and y-glutamylcysteine synthetase expression to protect neurons from 1-methyl-4-phenylpyridinium toxicity. Free Rad Biol Med, 49:1099-1108.

 

  1. Tsai MC, Chen WJ, Tsai MS, Ching CH, Chuang JI* (2011)  Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats. J Pineal Res. 51(2):233-245.