首頁師資〉專/兼任師資專長

吳勝男

吳勝男  (Wu, Sheng-Nan, M.D., Ph.D.)

 

生理學科暨生理所 教授 分機:5334    E-mail: snwu@mail.ncku.edu.tw

 

個人網址:http://phys.med.ncku.edu.tw/fac-snwu.php 

 

研究興趣

 

  1. 興奮細胞離子電流調控機制的探討。利用心臟細胞分離技術與細胞膜箝制技術,以研究細胞膜上各種不同離子通道的動力學變化。目前進行的研究如ATP-敏感性鉀離子通道,乙醯膽鹼活化性鉀離子通道等。
  2. 利用離子電流的模擬方式,做心臟動作電位特性的分析與探討,以了解動作電位的產生與心臟傳導系統的調控。
  3. 研究心律不整藥物對心臟細胞離子電流的作用機制。
  4. 研究興奮性細胞電壓依賴性離子電流的動力學特性。
  5. 開發不同藥物對細胞離子電流的影響。
  6. 開發興奮性細胞動作電位放放電的數學模式。

 

近五年代表作

 

  1. Wu, S.N., Peng, H., Chen, B.S., Wang, Y.J., Wu, P.Y., Lin, M.W. (2008) Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea1,3–bis-[2-hydroxy-5-  (trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells. Mol. Pharmacol. 74:1696-1704.
  2. Wang, Y.J., Chen, B.S., Lin, M.W., Lin, A.A., Peng, H., Sung, R.J., Wu, S.N. (2008) Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. Toxicol. Sci. 106:454-463.
  3. Huang, C.W., Huang, C.C., Lin, M.W., Wu, S.N. (2008) The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. Int. J. Neuropsychopharmacol. 11:597-610.
  4. Sung, R.J., Wu, Y.H., Lai, H.N., Teng, C.H., Luo, C.H., Tien, H.C., Lo, C.P., Wu, S.N. (2010) Beta-adrenergic modulation of arrhythmogenesis and identification of targeted sites of antiarrhythmic therapy in Timothy (LQT8) syndrome: a theoretical study. Am. J. Physiol. Heart Circ. Physiol. 298:H33-H44.
  5. Huang, C.W., Wu, Y.J., Wu, S.N. (2011) Modification of activation kinetics of delayed rectifier K+ currents and neuronal excitability by methyl--cyclodextrin. Neuroscience 176:431-441.
  6. Wu, S.N., Yeh, C.C., Huang, H.C., Yang, W.H: (2011) Cholesterol depletion with (2-hydroxypropyl)-b-cyclodextrin modifies the gating of membrane electroporation-induced inward current in pituitary tumor GH3 cells: experimental and analytical studies. Cell. Physiol. Biochem. 28:959-68.
  7. Wu, S.N., Yeh, C.C., Wu, P.Y., Huang, H.C., Tsai, M.L. (2012) Investigations into the correlation properties of membrane electroporation-induced inward currents: prediction of pore formation. Cell. Biochem. Biophys. 62:211-220.
  8. Liu, Y.C., Wu, P.C., Shieh, D.B., Wu, S.N. (2012) The effects of magnetitide (Fe3O4) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH3) cells and in RAW 264.7 macrophages. Int. J. Nanomed. 7:1687-1696.