首頁師資〉專/兼任師資專長

簡偉明

簡偉明  (Kan, Wai Ming, Ph.D.)

藥理所 副教授     

分機:5469    E-mail: vincent@mail.ncku.edu.tw

個人網址:

http://www.ncku.edu.tw/~pharma/pharmacology/main/3_teachers/7.html

 

研究興趣

 

1.      前列腺環素(prostacyclin) 對血癌細胞的分化及生長抑制的影响,及其中之訊息傳遞與作用機轉。

2.      前列腺環素(prostacyclin) 致效劑及抑制劑的設計及合成,並其在前列腺環素藥理及生理作用的研究的應用。

 

近五年代表作

1.    Shen, Huang-Wei; Chen, Yu-Lin, Chern, Ching-Yuh and Kan, Wai-Ming* (2007) Prostacyclin Agonists Inhibit Phorbol-12-Myristate-13-Acetate Induced Megakaryocytopoeisis in Human Erythroleukemia Cells Prostaglandins and Other Lipid Mediators 83, 231-236.

2.     Wai Ming Kan, Shih-Hsun Lin, Ching-Yuh Chern (2005) Efficient Synthesis of (N-substituted)-2-imidazolines and N-(N-substituted)-1,4,5,6-tetrahydropyrimidines. Synthetic Comm. 35: 2633–2639.

3.     Ching-Yuh Chern, Shinn-Jyh Chen and Wai-Ming Kan* (2005) Design and Synthesis of 3-Aryl-5-Allylic-[1.2.4]-oxadiazoles as Novel Platelet Aggregation Inhibitors. J. Chin. Chem. Soc. 52, 331-338.

4.     Wai Ming Kan, Ching-Lung Cheng and Ching-Yuh Chern (2004) One Pot Synthesis of Ene-lactams via N-debenzylation of Keto-containing N-2,4-dimethoxylbenzylamides Synthetic Comm. 34(23) 4257-4264.

5.     Ching-Yuh Chern, Yu-Ping Huang and Kan, Wai Ming* (2003) Selective N-debenzylation of Amides with p-TsOH Tetrahedron Lett. 44(5)1039-1041.