簡偉明

簡偉明 (Kan, Wai Ming, Ph.D.)

藥理所　副教授　     分機：5469　E-mail: vincent@mail.ncku.edu.tw

個人網頁：http://www.ncku.edu.tw/pharma/v2011/staff/7.html

研究興趣：

1. 氧自由基代謝酵素在骨髓性白血病的癌症生物學及抗癌葯物相關研究。
2. 慢性骨髓性白血病的抗癌藥物抗藥性作用機轉研究。

近五年代表作：

1. Ling-Yi Xiao, Wai-Ming Kan. (2017) p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells. Pharmacological Research. (in press).
2. Ling-Yi Xiao, Wai-Ming Kan (2017). Poly ADP-ribose polymerase inhibition suppresses cisplatin toxicity in chronic myeloid leukemia cells. Anti-Cancer Drugs, 28(3), 316-321.
3. Ling-Yi Xiao, Wai-Ming Kan. (2017) Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells. European Journal of Pharmacology, 794:201-208.
4. Yu-Lin Chen, Wai Ming Kan. (2015) Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , 1853(10 Pt A):2662-75.
5. Kan, W. M., Chao, C. S., Lin, S. J., Chen, C. H., Feng, J. Y., Lu, F. H., Lin, P. C., & Ho, T. S. (2013). Thanatology for Medical College Students – Cultivation of Medical Humanity.. Journal of Medical Education, 17(3), 97-106. (SCI).