首頁師資〉專/兼任師資專長

簡伯武

簡伯武  (Gean, Po-Wu, Ph.D.)

藥理所 講座教授     

分機:5507    E-mail: powu@mail.ncku.edu.tw

個人網址:

http://www.ncku.edu.tw/~pharma/pharmacology/main/3_teachers/5.html

 

研究興趣

  1. 學習和記憶是神經科學研究的一個重要領域,而扁桃體(Amygdala)之神經細胞和人類之學習和記憶有密切之關聯。目前我們利用一種動物行為模式,即長期增益現象,在老鼠扁桃體腦切片標本中,探討動物學習與記憶形成之細胞機轉,並利用藥理分析找出藥物可用於改善一些記憶不良之病人。
  2. 失智症是一種嚴重的退化性疾病可影響一個人的思維和記憶。老人癡呆症是失智症最常見的一種。我們利用兩種基因轉殖鼠作為老人癡呆症的動物模式,探討各種可以惡化或預防老人癡呆症的細胞或分子機制。我們最終的目標是經由生理及藥理實驗找出可防止老人痴呆之藥物。

 近五年代表作

  1. Mao SC, Chang CH, Wu CC,Orejanera J,Manzoni OJ and *Gean PW (2013) Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training. PLoS ONE 8(3): e59580.
  2. Kuo JR, Cheng YH, Chen YS, Chio CC and *Gean PW (2013) Involvement of extracellular signal regulated kinases (ERK1/2) in traumatic brain injury-induced depression in rodents. J Neurotrauma 30(14): 1223-1231.
  3. Liu WT, Huang CY, Lu IC and *Gean PW (2013) Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death. Neuro-Oncology 15: 1127-1141.
  4. Yu YJ, Chang CH and *Gean PW (2013) AMPA receptor endocytosis in the amygdala is involved in the disrupted reconsolidation of Methamphetamine-associated contextual memory. Neurobiol Lem Mem 103: 72-81.
  5. Chang HF, Su CL, Chang CH, Chen YW and *Gean PW (2013) The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice. Learn Mem 20: 328-335.
  6. Hsiao YH, Hung HC, Chen SH and *Gean PW (2014) Social interaction with a helper rescues memory deficit in an animal model of Alzheimer’s disease by increasing BDNF-dependent hippocampal neurogenesis. J Neurosci 34: 16207-16219.
  7. Chen YW, Lin HC, Hsiao YH,Ng MC, Wang CC,*Gean PW and *Chen PS (2014) Rescue of amygdala-associated autism-like phenotypes by N-acetylcystein in a rat model of valproate-induced autism. Front Beh Neurosci 8: 1-9.
  8. Liu WT, Chen C, Lu IC, Kuo SC, *Gean PW and *Hour MJ (2014) MJ-66 Induces Malignant Glioma Cells G2/M Phase Arrest and Mitotic Catastrophe through Regulation of Cyclin B1/Cdk1 complex. Neuropharmacology 86: 219-227.
  9. Hour MJ, Liu WT, Lu IC, Kuo SC, *Gean PW (2014) Aggravated DNA damage as a basis for enhanced glioma cell killing by MJ-66 in combination with minocycline. Am J Cancer Res 2014; 4(5):474-483.
  10.  Chang CH, Hsiao YH, Yu YJ and *Gean PW. (2015) Social isolation-induced increased NMDA receptors in ventral hippocampus primes mice for aggressive behaviors. Hippocampus 25: 474-485.
  11.  Hung HC, Hsiao YH and *Gean PW. (2015) Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation. Int J Neuropsychopharmacol (pyu071)
  12.  Hung HC, Hsiao YH and *Gean PW. (2015)Sonic hedgehog signaling regulates amygdalar neurogenesis and extinction of fear memory. European Neuropsychopharmacology 25: 1723-1732.
  13. Huang CH, Yu YJ, Chang CH and *Gean PW (2016) Facilitated extinction of methamphetamine-associated contextual memory by metabotropic glutamate 5 receptor positive modulator. J Neurochem 137: 216-225.
  14. Su CL, Su CW, Hsiao YH and *Gean PW (2016) Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. J Psychiatry Res 76: 101-110.
  15. Huang HC, Liu WT, Hua KS, Kuo SC, Huang LJ and *Gean PW (2016) α-Carboline derivative TJY-16 inhibits tumor growth by inducing G2/M cell cycle arrest in glioma Cells. J Biomedical Sci 23:10.
  16. Yu YJ, Huang CH, Chang CH, and *Gean PW (2016) Involvement of protein phosphatases in the destabilization of methamphetamine-associated contextual memory. Learning and Memory 23: 479-485.
  17. Hsiao YH, Hung HC, Yu YJ, Su CL, Chen SH, *Gean PW (2017) Co-housing reverses memory decline by epigenetic regulation of brain-derived neurotrophic factor expression in an animal model of Alzheimer’s disease. Neurobiol Learn Mem 141: 1-8.
  18. Hsiao YH, Chang CH, *Gean PW (2018) Impact of social relationships on Alzheimer’s memory impairment: mechanistic studies. J Biomed Sci 25:3.