首頁師資〉專/兼任師資專長

呂增宏

呂增宏  (Leu, Tzeng-Horng, Ph.D.)

藥理所 教授     分機:5468 E-mail: tzengleu@mail.ncku.edu.tw 

研究興趣:

  1. Oncogene的致癌機轉研究實驗室主要著眼在Src oncoprotein以及EGF receptor如何透過Eps8在細胞內作用而造成細胞不正常地生長與惡化,影響病人預後的能力。
  2. 抗癌藥物的研究:實驗室目前主要在探討細胞致癌機轉,期望經由細胞訊息傳遞的研究找到適合藥物的標靶,來專一性地抑制癌細胞生長。
  3. Src/Eps8 在巨噬細胞內參與的免疫功能研究實驗室發現Src/Eps8表現會受到TLRs的訊息調控。進一步發現。這些蛋白質會參與巨噬細胞的吞噬細菌與殺菌作用。透過此研究得以瞭解這些致癌蛋白在先天免疫的功能。

Research interests

  1. Oncogene study:

My laboratory is interested on the signal transduction mediated by EGF receptor and Src tyrosine kinases in cell proliferation.  We had identified Eps8 as a common substrate of Src and EGF receptor tyrosine kinases.  Eps8 overexpression induces cell transformation of murine fibroblast C3H10T1/2 and participates in v-Src-mediated transformation.  In human, Eps8 expression is correlated with the disease stage of colon cancer and affects prognosis of cervical cancer patient. 

  1. Anti-cancer drug research:

In addition to the oncogeneic role of Eps8, silencing Eps8 enables cervical cancer cells to become more sensitive to the cyto- toxicity of cisplatin and paclitaxel. Currently, we focus on the development of anti-Eps8 drug research.  Our final goal is to establish Eps8 as a potential target for cancer treatment.

  1. The role of Src/Eps8 in macrophage-mediated innate immunity:

Oncogenic proteins Src and Eps8 not only affect cell proliferation, but also regulate the motility and phagocytosis in macrophages. Currently, we are studying how they affect the function of macrophages in innate immunity.

近五年代表作:

1. Maa, M.-C., M. Y. Chang, M.-Y. Hsieh, Y.-J. Chen, C.-J. Yang, Z.-C. Chen, Y. K. Li, C.-K. Yen, R.-R. Wu, and T.-H. Leu.* (2010) Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of src enhancement and focal adhesion kinase activity. J Nutr Biochem 21, 1186-1192.

2. Liu, P.-S., T.-H. Jong, M.-C. Maa, and T.-H. Leu.* (2010) The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation. Oncogene 29, 3977-3989.

3. Maa, M.-C., M. Y. Chang, J. Li, Y.-Y. Li, M.-Y. Hsieh, C.-J. Yang, Y.-J. Chen, Y. Li, H.-C. Chen, W. E. Cheng, C.-Y. Hsieh, C.-W. Cheng, and T.-H. Leu.* (2011) The iNOS/Src/Fak axis is critical in Toll-like receptor-mediated cell motility in macrophages. Biochim. Biophys. Acta 1813, 136-147. 

4. Chen, Y.-J., M.-Y. Hsieh, M. Y. Chang, H.-C. Chen, M.-S. Jan, M.-C. Maa, and T.-H. Leu.* (2012)Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in LPS-stimulated macrophages. J Biol Chem 287, 18806-18819.

5. Maa, M.-C. and T.-H. Leu.* (Jan. 23, 2013) EPS8, an adaptor protein acts as an oncoprotein in human cancer. Carcinogenesis (ISBN 978-953-51-0945-7; edited by Kathryn Tonissen; published by InTech, Croatia) Chapter 5, pp. 87-104. (http://dx.doi.org/10.5772/54906) (專書)

6. Hsieh, M.-Y., M. Y. Chang, Y.-J. Chen, Y. K. Li, T.-H. Chuang, G.-Y. Yu, C. H. Cheung, H.-C. Chen, M.-C. Maa, T.-H. Leu.* (2014)The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction leading to interferon-b synthesis in macrophages. J Biol Chem. 289, 9208-9222.