賴明德

賴明德  (Lai, Ming-Derg, Ph.D.)

生化所 教授　

分機：5549    E-mail: a1211207@mail.ncku.edu.tw

個人網址：http://www.ncku.edu.tw/~biochem/profs/MDLAI/introduc.htm

研究興趣：

1. 癌症的基因治療，利用腫瘤抗原之DNA疫苗啟動免疫系統摧毀癌症細胞，並採用複合治療法以達到最佳治療效果。
2. 內質網壓力和肝癌發生訊息傳遞之研究：利用HBV large surface protein 作為研究模式了解肝細胞如何因對抗內質網壓力而導致癌化現象。
3. 研究Ste20-like MST3 kinase在生物體內的功能。

近五年代表作：

1. Lin CC, Tu CF, Yen MC, Chen MC, Hsieh WJ, Chang WC, Chang WT, Lai MD* (2007) Inhibitor of heat shock protein 90 enhances the anti-tumor effect of DNA vaccine targeting clients of heat shock protein. Mol. Ther. 15: 404-410.
2. Ling P, Lu TJ, Yuan CJ, Lai MD* (2008) Biosignalling of mammalian ste20 related kinase. Cell. Signal. 20:1237-47. 
3. Lin CC, Yen MC, Lin CM, Huang SS, Yang HJ, Chow NH, and Lai MD* (2008) Skin delivery with non-carrier naked DNA vaccine by supersonic flow polarizes Th1 immune response against cancer. J. Gene Med. 10:679-689.
4. Yen MC, Lin CC, Chen YL, Huang SS, Yang HJ, Chang CP, Lei HY, Lai MD*. (2009) A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA. Clin. Cancer Res. 15:641-649..
5. Lai MD, Chen CS, Chi-Rei Yang CR, Yuan SY, Tsai JJ, Tu CF, Wang CC, Yen MC, Lin CC. (2010) HDAC inhibitor enhances anti-tumor response of CMV promoter –driven DNA vaccine. Cancer Gene Ther. 17:203-11.
6. Yang HJ, Yen MC, Lin CC, Lin CM, Chen YL, Weng TY, Huang TT, Wu CL, Lai MD*. (2010) A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. Exp Biol Med. 235:869-76.
7. Chang YS, Tsai CT, HuangFu CA, Huang W, Lei HY,Lin CF, SuIJ, Chang WT, Wu PH, Chen YT, Hung JH, Young KC, Lai MD* (2011) ACSL3 and GSK-3beta are essential for lipid upregulation induced by Endoplasmic reticulum stress in liver cells. J Cell Biochem. 112:881-93
8. Huang TT, Yen MC, Lin CC; Weng TY, Chen YL, Lin, CM, Lai MD*. (2011) Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces anti-tumor immunity against orthotopic and metastatic liver cancer. Cancer Sci. 102:2214-20.