首頁師資〉教師指導學生

陳炳焜

陳炳焜(Chen Ben-Kuen, Ph.D.)   

藥理學研究所  教授      分機:5470       Email: bkchen58@mail.ncku.edu.tw

研究興趣:

腫瘤轉移及抗藥性

轉移性的癌細胞較惡性並且具有抗藥性而成為癌症主要的死因,存在循環系統中的轉移性細胞不僅能夠抗失巢凋亡,也能躲過免疫偵測而達成轉移的目的,然而存在微環境當中的一群訊號分子,能特異性的啟動腫瘤體轉移侵犯到血管的機制,而癌細胞如何滲透及植入遠端組織,其中的相關分子及機轉尚未釐清。

研究議題及策略

一般而言,有關癌轉移的研究皆聚焦在原位癌或是已經轉移成功的組織中,然而循環系統中的微環境其重要性在轉移過程中常被忽略,如何調控腫瘤細胞在無依存的微環境存活及促進遠端轉移仍然未知。我們使用細胞及動物模式,並且根據其臨床相關性,來研究細胞激素,包括PGE2, ANGPTL4及PTX3如何調控頭頸癌腫瘤的抗失巢凋亡、轉移及抗藥性,這些主要議題的探討將能應用於相關癌症的治療及抗藥性,研究結果將能釐清ANGPTL4及PTX3如何影響COX-2的活化作用與促進腫瘤轉移的關係,以及COX-2抑制劑,例如希樂葆及阿斯匹靈對於在癌正轉移預防的效果評估。

近五年代表作:

  1. Hsu JY, Chang JY, Chang KY, Chang WC, Chen BK (2017) Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin. FASEB J 31, 4265-4276
  2. Chan SH, Tsai JP, Shen CJ, Liao YH and Chen BK (2017) Oleate-induced PTX3 promotes head and neck squamous cell carcinoma metastasis through the up-regulation of vimentin. Oncotarget 8, 41364-41378
  3. Shen CJ, Chan SH, Lee CT, Huang WC, Tsai JP and Chen BK (2017) Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin. Cancer Lett. 386, 110-122
  4. Liao YH, Chiang KH, Shieh JM, Huang CR, Shen CJ, Huang WC and Chen BK (2017) Epidermal growth factor-induced ANGPTL4 enhances anoikis resistance and tumor metastasis in head and neck squamous cell carcinoma. Oncogene 36, 2228-2242
  5. Huang CR;Lee CT;Chang KY;Chang WC;Lee JC;Chen BK*,"Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis",Oncotarget;vol : 6, no : , pp : 11530- 11546(SCI 2015)
  6. Chang WC;Wu SL;Huang WC;Hsu JY;Wang JM;Tsai JP;Chen BK*,"PTX3 gene activation in EGF-induced head and neck cancer cell metastasis",Oncotarget;vol : 6, no : , pp : 7741- 7757(SCI 2015)
  7. Zhang J;Koussih L;Shan L;Halayko AJ;Chen BK;Gounni AS*,"TNF up-regulates pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways",Allergy, Asthma and Clinical Immunology;vol : 11:37, no : (SCI 2015)
  8. Yang IH;Wong JH;Chang CM;Chen BK;Tsai YT;Chen WC;Wang ET;Hsu WL;Chang WC*,"Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells",Ophthalmol. Vis. Sci.;vol : 56, no : , pp : 761- 769(SCI 2015)
  9. Hsu JY;Chang KY;Chen SH;Lee CT;Chang ST;Cheng HC;Chang WC;Chen BK*,"Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation",Oncotarget;vol : 6, no : , pp : 1723- 1739(SCI 2015)