首頁師資〉專/兼任師資專長

吳偉立

吳偉立 (Wei-Li Wu, Ph.D.)

生理學科暨研究所 助理教授 分機:5458/5435  E-mail: wlwu@mail.ncku.edu.tw

研究興趣

  1. 探討腸道微生物對自閉症的影響
  2. 探討腸道微生物代謝物對壓力的影響
  3. 利用化學遺傳學探討腸-腦軸的關聯

近五年代表作

  1. Wu, W.L.*,Adame, M.D., Tang, W., Schretter, C.E., Wang, M., Abdel-Haq, R., Beadle, K., Deverman, B.E., Gradinaru, V., Mazmanian, S.K.*, Gut microbiota regulate social behavior via stress response pathways in the brain. (In Revision)
  2. Wu, W.L.*, Cheng, S.J., Lin, S.H., Chuang, Y.C., Huang, E.Y., Chen, C.C.*, 2019. The effect of ASIC3 knockout on corticostriatal circuit and mouse self-grooming behavior. Frontiers in Cellular Neuroscience, 13:86. doi: 10.3389/fncel.2019.00086.eCollection 2019.
  3. Lee, Y.K., Mehrabian, P., Boyajian, S., Wu, W.L., Selicha, J., Vonderfecht, S., Mazmanian, S.K., 2018. The Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal Cancer. mSphere, 3(6). pii: e00587-18. doi: 10.1128/mSphere.00587-18..
  4. Ko, J., Isas, J.M., Sabbaugh, A., Yoo, J.H., Pandey, N.K., Chongtham, A., Ladinsky, M., Wu, W.L., Rohweder, H., Weiss, A., Macdonald, D., Munoz-Sanjuan, I., Langen, R., Patterson, P.H., Khoshnan, A., 2018. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human molecular genetics, 27, 2330-2343.
  5. Needham, B.D., Tang, W., Wu, W.L.*, 2017. Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Developmental Neurobiology, 78, 474-499.
  6. Wu, W.L.*, 2017. Association among gut microbes, intestinal physiology, and autism. EBioMedicine, 25. 11-12.
  7. Chan, K.Y., Jang, M.J., Yoo, B.B., Greenbaum, A., Ravi, N., Wu, W.L., Óscar Sánchez-Guardado, L., Lois, C., Mazmanian, S.K., Deverman, B.E.*, Gradinaru, V.*, 2017.Engineered adeno-associated viruses for efficient and noninvasive gene delivery throughout the central and peripheral nervous systems. Nature Neuroscience, 20, 1172-1179.
  8. Wu, W.L.*, Hsiao, E.Y., Yan, Z., Mazmanian, S.K., Patterson, P.H., 2017. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain, Behavior, and Immunity. 62, 11-23
  9. Highlighted in: Brain, Behavior, and Immunity. 62: 9-10.
  10. Chu, H.*, Khosravi, A., Kusumawardhani, I.P., Kwon, A.H., Vasconcelos, A.C., Cunha, L.D., Mayer, A.E., Shen, Y., Wu, W.L., Kambal, A., Targan, S.R., Xavier, R.J., Ernst, P.B., Green, D.R., McGovern, D.P., Virgin, H.W., Mazmanian, S.K.*, 2016. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science, 352, 1116-1120.
  11. Chow, K.H., Yan, Z., Wu, W.L.*, 2016. Induction of maternal immune activation in mice at mid-gestation stage with viral mimic poly(I:C). Journal of Visualized Experiments: JoVE, e53643.
  12. Deverman, B.E.*, Pravdo, P.L., Simpson, B.P., Kumar, S.R., Chan, K.Y., Banerjee, A., Wu, W.L., Yang, B., Huber, N., Pasca, S.P., Gradinaru, V.*, 2016. Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nature Biotechnology, 34, 204-209.
  13. Wu, W.L.*, Adams, C.E., Stevens, K.E., Chow, K.H., Freedman, R., Patterson, P.H., 2015. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain, Behavior, and Immunity, 46, 192-202.