首頁師資〉教師指導學生

莊偉哲

莊偉哲  (Chuang, Woei-Jer, Ph.D.)

生化所教授 分機:5515 E-mail: wjcnmr@mail.ncku.edu.tw

個人網頁:http://www.ncku.edu.tw/biochem/profs/wjchuang/introduc.htm

研究興趣

1. 去結合蛋白運用於血小板凝聚與癌細胞轉移之研究

2. 三環毒素與其結合受体之研究

3. 翼狀螺旋轉錄因子與其致病突變蛋白之研究

4. A群鏈球菌的致命因子熱原性外毒素B之研究

5. 中草藥有療效成份之分離(鯊魚軟骨、冬蟲夏草、巴西洋菇)

 

近五年代表作

1.   Wang, C.-C., Houng, H.-C. , Kuo, C.-F., Lin, Y.-S., Wu, J.-J., Lin. M.-T., Liu, C.-C., Chen, C.-Y., Huang, W., and Chuang, W.-J. (2009) "Solution Structure and Backbone Dynamics of Streptopain: Insight into Diverse Substrate Specificity", J. Biol. Chem., 284, 10957-10967.

2.   Chen, C.-Y., Liu, Y.-C., Hsieh Y.-H., Shiu, J.-H., Chen, Y.-C., Tang, M.-J., Lo, Szecheng J., and Chuang, W.-J. (2009) "Effect of D to E Mutation of the RGD Motif in Rhodostomin on its Activity, Structure, and Dynamics: Importance of the Interactions Between the D Residue and Integrin", Proteins, 76, 808-821.

3.   Anangi, R., Chen, C.-C., Lin Y.-W., Cheng, Y.-R., Cheng, C.-H., Chen, Y.-C., Chu, Y.-P., and Chuang, W.-J. (2010) “Expression in Pichia pastoris and Characterization of APETx2, a Specific Inhibitor of Acid Sensing Ion Channel 3”, Toxicon, 56, 1388-1397.

4.   Chu, Y.-P., Chang, C.-H., Shiu, J.-H., Chang, Y.-T., Chen, C.-Y., and Chuang, W.-J. (2011) “Solution Structure and Backbone Dynamics of the DNA-Binding Domain of FOXP1: Insight into its Domain Swapping”, Protein Science, 20, 908-924.

5.   Shiu, J.-H., Chen, C.-Y., Chen, Y.-C., Chang, Y.-T., Chang, Y.-S., Huang, C.-H., and Chuang, W.-J. (2012) ”Effect of P to A mutation of the N-terminal residue adjacent to the RGD motif in rhodostomin on its activity, structure, and dynamics: Importance of dynamic properties in the recognition of integrin ”, Plos One, 7, e28833.

6.  Cheng CH, Chen YC, Shiu JH, Chang YT, Chang YS, Huang CH, Chen CY, Chuang WJ. (2012)  Dynamics and functional differences between dendroaspin and rhodostomin: Insights into protein scaffolds in integrin recognition. Protein Science,21(12): 1872-84.

7. Chen YC, Cheng CH, Shiu JH, Chang YT, Chang YS, Huang CH, Lee JC, Chuang WJ. (2012)  Expression in Pichia pastoris and characterization of Echistatin, a RGD-containing short disintegrin. Toxicon, 60(8):1342-8.