首頁師資〉教師指導學生

林世杰

林世杰 (Shih-Chieh Lin, Ph.D.)

基醫所助理教授   分機:6226    E-mail: Jaylin@mail.ncku.edu.tw

研究興趣:

利用各種生物資訊工具探勘各式公用生物訊息資料庫,藉此衍生新穎研究方向、降低研究成本及試誤學習之時間,再結合細胞生物及分子生物學,用以探討疾病生成之致病機制以及開發可能的治療方向

研究方向:

1. 探討子宮內膜異位症之致病機轉以及發展新穎之治療方法

2. 研究前列腺癌第二代雄激素阻斷治療藥物生成抗藥性機制及發展可能之治療方法

3. 研究mRNA 3'端未轉譯區(3'-untranslated region)之轉換於疾病生成的影響為何

近五年代表作:

  1. P Li, SY You, C Nguyen, Y Wang, J Kim, D Sirohi, A Ziembiec, DJ. Luthringer, SC Lin, T Daskivich, J Wu, MR. Freeman, R Saouaf, D Li, HL. Kim. Genes involved in prostate cancer progression determine MRI visibility. Theranostics 2018; 8(7):1752-1765.
  2. PC Hou, YH Li, SC Lin, JC Lee, PW Lin, JP Liou, JY Chang, C-C Kuo, YM Liu, HS Sun and SJ Tsai. Downregulation of Dual Specificity Phosphatase-2 by Hypoxia Promotes Colon Cancer Stemness and Drug Resistance. Cancer Res. Aug 15;77(16):4305-4316 IF:9.122; Rank: 15/217 (Oncology)
  3. SC Lin, HC Lee, PC Hou, JL Fu, MH Wu and SJ Tsai. Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising material fertility J Pathol. (Cover page) 2017 Aug;242(4):476-487. IF: 7.381; Rank: 3/78 (Pathology).
  4. HJ Lee, CY Kao, SC Lin, M Xu , X Xie , S Y Tsai, MJ Tsai. Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development. Sci Rep. 2017 Jun 9;7(1):3136 IF: 5.228; Rank: 7/63 (Multidisciplinary Sciences)
  5. SC Lin *, KY Hsiao*, N Chang, PC Hou, and SJ Tsai. Loss of dual specificity phosphatase-2 promotes angiogenesis and metastasis via upregulation of interleukin-8 in colon cancer. J Pathol. 2017 Apr;241(5):638-648 c*: SC Lin and KY Hsiao contributed equally to this study. IF: 7.381; Rank: 3/78 (Pathology).
  6. SC Lin, CY Kao, HJ Lee, CJ Creighton, MM Ittmann, SJ Tsai, SY Tsai, MJ Tsai. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer Nat Commun. 2016 Apr 25;7:11418. doi: 10.1038/ncomms11418. IF: 11.329; Rank: 3/63 (Multidisciplinary Sciences)
  7. YH Liu, YS Tsai, SC Lin, NS Liao, MS Jan, CT Liang, SW Hsu, WC Chen, JM Sung, N Maeda, PJ Tsai. Quantitative PPARγ expression affects the balance between tolerance and immunity. Sci Rep. 2016 May 25;6:26646. doi: 10.1038/srep26646. IF: 5.228; Rank: 7/63 (Multidisciplinary Sciences)
  8. HC Tai, PJ Tsai, JY Chen, CH Lai, KC Wang, SH Teng, SC Lin, A Chang, MJ Jiang, YH Li, HL Wu, N Maeda, YS Tsai. PPARγ level contributes to structural integrity and component production of elastic fibers in the aorta Hypertension Hypertension. 2016 Jun;67(6):1298-308 IF:6.294; Rank: 3/63 (Peripheral Vascular Disease)
  9. CW Chien, PC Hou, HC Wu, YL Chang, SC Lin, SC Lin, BW Lin, JC Lee, YJ Chang, HS Sun, SJ Tsai. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene. 2016 Nov 10;35(45):5872-5881. IF: 7.932; Rank: 15/213 (Oncology)
  10. J Qin, HJ Lee, SP Wu, SC Lin, RB Lanz, CJ Creighton, FJ DeMayo, SY Tsai, MJ Tsai. Androgen deprivation-induced NCoA2 promotes metastatic and castration resistant prostate cancer. J Clin Invest. 2014 Nov;124(11):5013-26 IF: 12.575; Rank: 3/124 (Medicine, Research & Experimental)
  11. SC Lin *, YH Li *, MH Wu, YF Chang, DK Lee, SY Tsai, MJ Tsai, SJ Tsai. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. *: SC Lin, YH Li contributed equally to this study. J Clin Endocrinol Metab. 2014 Mar; 99(3):E427-37. doi: 10.1210/jc.2013-3717. Epub 2014 Jan 1 IF: 5.531; Rank: 16/131 (Endocrinology and Metabolism)