首頁師資〉教師指導學生

陳呈堯

陳呈堯 (Cheng-Yao Chen, Ph.D.)                                    

醫學檢驗生物技術學系 助理教授 分機:5790  Email:chengyao@mail.ncku.edu.tw

個人網址:https://tw.linkedin.com/in/cheng-yao-chen-394326bb

專長與研究興趣:

蛋白質工程技術與生物科技的應用,本實驗室未來研究的四大主題:

  1. DNA聚合酶 (DNA polymerases) 與核酸修飾蛋白(DNA modification enzymes)的基礎研究與生物科技的應用
  2. 核酸分子檢測技術的開發與臨床應用
  3. 次世代基因定序技術的開發與臨床應用
  4. 基因合成(gene synthesis)技術的開發與應用

近五年代表作:

  1. Previte, M. J., Zhou, C., Kellinger, M., Pantoja, P., Chen, C.-Y, Shi, J., Wang, B., Kia, M., Viecelli, J., Nikoomanzar, A., Bomati, E., Ronaghi, M., He, M. (2015) DNA sequencing method using polymerase binding kinetics. Nature Communications 6:5936-47
  2. Chen, C.-Y. (2014) DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present. Front. Microbiol.5:305 (Invited Reviews)
  3. Kennedy, S. R., Chen C.-Y, Schmitt, M. W., Bower, C. N., and Loeb, L. A. (2011) The biochemistry and fidelity of synthesis by the apicoplast genome replication DNA polymerase Pfprex from the malaria parasite Plasmodium falciparum. J. Mol. Biol. 410(1): 27-38
  4. US8999674 “Method and apparatus for single molecule sequencing using energy transfer detection”
  5. US9255258 “Nucleotide transient binding for sequencing methods
  6. US9150896 “Nucleotides and primers with removable blocking group”
  7. US20110014612 “Polymerase compositions and methods”
  8. US20110312529 “Conformational probes and methods for sequencing nucleic acids”
  9. US20130165328 “Apparatus and methods for kinetic analysis & determination of nucleic acid sequences”
  10. US20150376582 “Modified polymerases for improved incorporation of nucleotide analogues”
  11. US20160032377 “Modified polymerases for improved incorporation of nucleotide analogues”
  12. US20160090579 “Modified polymerases for improved incorporation of nucleotide analogues”
  13. US20160017416 “Biochemically activated electronic device”
  14. US 61/994,498 “Nucleic acid synthesis techniques”