首頁師資〉教師指導學生

陳百昇

陳百昇 (Pai-Sheng Chen, Ph.D.)                                     

醫學檢驗生物技術學系 助理教授 分機:6233   Email: bio.benson@gmail.com

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

專長與研究興趣:

  1. 癌症生物學
  2. 微核糖核酸(microRNA)在人類惡性腫瘤中扮演之功能
  3. 微核糖核酸(microRNA)之生成(biogenesis)機制
  4. 個人化精準醫療 

 

近五年代表作:

 

  1. Su CM, Wang MY, Hong CC, Chen HA, Su YH, Wu CH, Huang MT, Chang YW, Jiang SS, Sung SY, Chen PS and Su JL. miR-520h is crucial for DAPK2 regulation and breast cancer progression. Oncogene. 2016 Mar 3;35(9):1134-42. doi: 10.1038/onc.2015.168. Epub 2015 May 18.
  2. Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH, Hung MC, Hsu NW, Shiah SG, Hsu NY, Su JL. miR326 Maturation Is Crucial for VEGF-C-Driven Cortactin Expression and Esophageal Cancer Progression. Cancer Res. 2014 Nov 1;74(21):6280-90. doi: 10.1158/0008-5472.CAN-14-0524. Epub 2014 Sep 9. 
  3. Chang YW, Su CM, Su YH, Ho YS, Lai HH, Chen HA, Kuo ML, Hung WC, Chen YW, Wu CH, Chen PS, Su JL. Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects. Oncotarget. 2014 Jun 15;5(11):3823-35.
  4. Kuo TC, Chang YW, Hong CC, Lee WJ, Chen MW, Jeng YM, Chiou J, Yu P, Chen PS, Wang MY, Michael Hsiao, Su JL, Kuo ML. ANGPTL1/integrin α1β1 axis represses Slug–mediated cancer cells motility through miR-630. J Clin Invest. 2013 Mar 1;123(3):1082-95. doi: 10.1172/JCI64044
  5. Chen PS, Su JL, Hung MC. Dysregulation of microRNAs in cancer. J Biomed Sci. 2012 Oct 17;19:90. doi: 10.1186/1423-0127-19-90. 
  6. Yu YH, Chen HA, Chen PS, Cheng YJ, Hsu WH, Chang YW, Chen YH, Jan YH, Michael Hsiao, Chang TY, Liu YH, Jeng YM, Wu CH, Huang MT, Su YH, Hung MC, Chien MH, Kuo ML, Su JL. MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol. Oncogene.2013 Jan 24;32(4):431-43. doi: 10.1038/onc.2012.74.
  7. Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Michael Hsiao, Chang YW, Chen JS, Yang PC, Kuo ML. MiR-107 Promotes Tumor Progression by Targeting the Let-7 MicroRNA in Mice and Humans. J Clin Invest. 2011 Sep 121(9):3442–3455.doi:10.1172/JCI45390. 
  8. Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M, Kuo ML. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell. 2011 Feb 15;19(2):218-31.