首頁師資〉教師指導學生

陳百昇

陳百昇 (Pai-Sheng Chen, Ph.D.)                                     

醫學檢驗生物技術學系 助理教授 分機:6233   Email: bio.benson@gmail.com

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

專長與研究興趣:

  • Function and regulation of non-coding RNA and RNA-binding protein
  • Cancer biomarker
  • Precision oncology

近五年代表作:

Selected Publications - Serving as a Principal Investigator:

Refereed Paper (*corresponding author):

  1. Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, Pai-Sheng Chen*. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest.2018;128(2):625–643. doi:10.1172/JCI89212.
  2. Hui-Huang Lai, Pai-Sheng Chen*. Dual mechanism of Dicer downregulation facilitates cancer metastasis. Molecular & Cellular Oncology. 2018 Aug 24;5(5):e1472056. doi: 10.1080/23723556.2018.1472056. eCollection 2018.
  3. Hui-Huang Lai, Li-Jyuan Lin, Liang-Yi Hung and Pai-Sheng Chen*. Role of Dicer in regulating oxaliplatin resistance of colon cancer cells. Biochem Biophys Res Commun. 2018. 506:87-93. pii: S0006-291X(18)32227-7. doi: 10.1016/j.bbrc.2018.10.071. [Epub ahead of print].
  4. Hui-Huang Lai, Chih-Wei Li, Chih-Chen Hong, Hung-Yu Sun, Ching-Feng Chiu, Da-Liang Ou*, Pai-Sheng Chen*. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Molecular Oncology. 2019 Jan 18. doi: 10.1002/1878-0261.12449. [Epub ahead of print]
  5. Ming-Yang Wang*, Hsin-Yi Huang, Yao-Lung Kuo, Chiao Lo, Hung-Yu Sun, Yu-Jhen Lyu, Bo-Rong Chen, Jie-Ning Li, Pai-Sheng Chen*. TARBP2-Enhanced Resistance During Tamoxifen Treatment in Breast Cancer. Cancers. 2019, 11(2), 210; doi.org/10.3390/cancers11020210.

Seminar Invitation:

  1. Pai-Sheng Chen*. A noncanonical HIF-1alpha pathway for metastasis control.第13屆海峽兩岸細胞生物學學術研討會 2018/07/18-22 (Invited speaker)

Book Chapter:

  1. Pai-Sheng Chen*. Regulation of Selective Proteolysis in Cancer. The Ubiquitin/Proteasome System. In production. Matthew Summers, editor, IntechOpen, London, UNITED KINGDOM. ISBN 978-953-51-7766-1 (Invited book chapter)

Conference Paper:

  1. Chih-Wei Li, Hui-Huang Lai, Da-Liang Ou, Pai-Sheng Chen*. Role of TARBP2 in regulating sorafenib resistance of hepatocellular carcinoma cells. 2017 The 32rd Joint Annual Conference of Biomedical Science
  2. Jie-Ning Li, Yao-Lung Kuo, Wen-Hui Ku, Yu-Jhan Lu, Ming-Yang Wang, Pai-Sheng Chen*. Membrane-anchored E-cadherin/Ago2 complex promote non-canonical miRNA biogenesis of miR-451a. American society of biochemistry and molecular biology, Experimental Biology meeting. 2018/04/24
  3. Yao-Lung Kuo, Jie-Ning Li, Yi-Ting Chen, Ming-Yang Wang, Pai-Sheng Chen*. Prognostic value of snoRNA U50A and its regulatory function in breast cancer. Taiwan Surgical Association 2018 Annual meeting. 2018/03/18
  4. Yao-Lung Kuo, Jie-Ning Li, Yi-Ting Chen, Ming-Yang Wang, Pai-Sheng Chen*. Small nucleolar RNAs as novel biomarkers for breast cancer. European Breast Cancer Conference. 2018/3/21-23
  5. Wen-Hui Ku, Jie-Ning Li, Pai-Sheng Chen*. Role of RRP6 in breast cancer. 2018 The 33rd Joint Annual Conference of Biomedical Science
  6. Hei Chen, Yu-Jhen Lyu, Yao-Lung Kuo, Tzu-Fun Fu, Pai-Sheng Chen*. The TRBP-targeting drug screening identified Chinese herbs that sensitize breast cancer cells to tamoxifen treatment. 2018 The 33rd Joint Annual Conference of Biomedical Science

Patent:

   14. Using TRBP as a biomarker for hormone therapy resistance. Pai-Sheng Chen, Jie-Ning Li,             Ming-Yang Wang, Yao-Lung Kuo. US provisional patent, Application number 62/641,387.

   15. Detecting snoRNAs expression for breast cancer diagnosis and prediction of prognosis. Pai-           Sheng Chen, Jie-Ning Li, Yao-Lung Kuo US provisional patent, Application number                       62/641,385.