首頁師資〉專/兼任師資專長

陳百昇

陳百昇 (Pai-Sheng Chen, Ph.D.)                                     

醫學檢驗生物技術學系 助理教授 分機:6233   Email: bio.benson@gmail.com

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

專長與研究興趣:

  • Function and regulation of non-coding RNA and RNA-binding protein
  • Cancer biomarker
  • Precision oncology

近五年代表作:

  1. Hui-Huang Lai, Jie-Ning Li, Ming-Yang Wang, Hsin-Yi Huang, Carlo M. Croce, Hui-Lung Sun, Yu-Jhen Lyu, Jui-Wen Kang, Ching-Feng Chiu, Mien-Chie Hung, Hiroshi I. Suzuki, Pai-Sheng Chen*. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest.2018;128(2):625–643. doi:10.1172/JCI89212. (*corresponding author)
  2. Hui-Huang Lai, Pai-Sheng Chen*. Dual mechanism of Dicer downregulation facilitates cancer metastasis. Molecular & Cellular Oncology. 2018 Aug 24;5(5):e1472056. doi: 10.1080/23723556.2018.1472056. eCollection 2018. (*corresponding author)
  3. Hui-Huang Lai, Li-Jyuan Lin, Liang-Yi Hung and Pai-Sheng Chen*. Role of Dicer in regulating oxaliplatin resistance of colon cancer cells. Biochem Biophys Res Commun. 2018. 506:87-93. pii: S0006-291X(18)32227-7. doi: 10.1016/j.bbrc.2018.10.071. [Epub ahead of print]. (*corresponding author)
  4. Hui-Huang Lai, Chih-Wei Li, Chih-Chen Hong, Hung-Yu Sun, Ching-Feng Chiu, Da-Liang Ou*, Pai-Sheng Chen*. TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma. Molecular Oncology. 2019 Jan 18. doi: 10.1002/1878-0261.12449. [Epub ahead of print] (*corresponding author)
  5. Ming-Yang Wang*, Hsin-Yi Huang, Yao-Lung Kuo, Chiao Lo, Hung-Yu Sun, Yu-Jhen Lyu, Bo-Rong Chen, Jie-Ning Li, Pai-Sheng Chen*. TARBP2-Enhanced Resistance During Tamoxifen Treatment in Breast Cancer. Cancers. 2019, 11(2), 210; doi.org/10.3390/cancers11020210. (*corresponding author)
  6. Pai-Sheng Chen*. Regulation of Selective Proteolysis in Cancer. The Ubiquitin/Proteasome System. In production. Matthew Summers, editor, IntechOpen, London, UNITED KINGDOM. ISBN 978-953-51-7766-1 (Invited book chapter) (*corresponding author)