首頁師資〉專/兼任師資專長

王仰高

王仰高 (Yang-Kao Wang. Ph.D.)                                      

細胞生物暨解剖學研究所助理教授 分機:5333   Email: humwang@mail.ncku.edu.tw

個人網址:http://www.anatomy.ncku.edu.tw/people/bio.php?PID=94

專長與研究興趣

  1. 細胞外微環境 (物理及化學因子)如何調控骨髓間質幹細胞之生長及分化
  2. 細胞收縮力之調控
  3. 細胞骨架的動態及組成對細胞功能的影響

近五年代表作

 

  1. Chen HR, Yeh YC, Liu CY, Wu YT, Lo FY, Tang MJ, Wang YK*. DDR1 promotes E-cadherin stability via inhibition of integrin b1-src activation mediated E-cadherin endocytosis. Sci Rep 6:36336, 2016
  2. Harn HI, Hsu CK,Wang YK, Huang YW, Chiu WT, Lin HH, Cheng CM, Tang MJ. Spatial distribution of filament elasticity determines the migratory behaviors of a cell. Cell Adh Migr. 2016, accepted.
  3. Sung CY, Yang CY, Chen WS, Wang YK, Yeh JA, Cheng CM. Probing neural cell behaviors through micro-/nano-patterned chitosan substrates. Biofabrication 7: 045007, 2015
  4. Pan BS, Wang YK, Lai MS, Mu YF, Huang BM. Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Sci Rep 5:13372, 2015
  5. Liu CY, Lin HH, Tang MJ*, Wang YK*. Vimentin contributes to epithelial-mesenchymal  maturation. Oncotarget, 6:15966-2015, (Corresponding)
  6. transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion
  7. Han HI, Wang YK, Hsu CK, Ho YT, Huang YW, Chiu WT, Lin HH, Cheng CM, Tang MJ. Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migration nature of keloid fibroblasts. Exp Dermatol, 24:579-84, 2015.
  8. Yu HW, Chen YQ, Huang CM, Liu CY, Chiou A, Wang YK, Tang MJ, Kuo JC. β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration. J Cell Mol Med 19: 934-47, 2015.
  9. Huang IH, Hsiao CT, Wu JC, Shen RF, Liu CY, Wang YK, Chen YC, Huang CM, del Álamo JC, Chang ZF, Tang MJ, Khoo KH, Kuo JC. GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. J Cell Sci127:4186-200, 2014
  10. So EC, Lin YX, Pan BS, Cheng KS, Wong KL, Hao LJ, Wang YK* and Huang BM*. Midazolam stimulates caspase and MAPK, but inhibits Akt, pathways to induce apoptosis in MA-10 mouse Leydig cells.,OncoTargets and Therapy 7:211-7, 2014. (Corresponding)
  11. Wu KC, Tseng CL, Wu CC, Kao FC, Tu YK, So EC, Wang YK*. Nanotechnology in the regulation of stem cell behavior. Sci Tech Adv Mater,14:054401, 2013. (Corresponding)
  12. Lee YH, Huang JR, Wang YK, and Lin KH. Three-dimensional fibroblast morphology on compliant and negatively curved substrates. Integrative Biol. 5:1447-55, 2013.
  13. Wang YK*, Chen CS. Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation. J Cell Mol Med.17: 823-32, 2013. (Corresponding)
  14. Wang YK, Yu X, Cohen DM, Wozniak MA, Yang MT, Gao L, Eyckmans J, and Chen CS. BMP-2-Induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension. Stem Cell Dev. 21: 1176-86, 2012.
  15. Yang MT, Fu J, Wang YK, Desai R, and Chen CS. Assaying stem cell mechanoniology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protocol. 6:187- 213, 2011.
  16. Fu JP#, Wang YK#, Yang MT, Desai, RD, Yu X, Liu ZJ, Chen CS. Mechanical regulation of cell function using geometrically modulated elastomeric substrates. Nat Methods. 7: 733-6, 2010. (#, equal contribution)