首頁師資〉教師指導學生

張雅雯

張雅雯 (Alice Y.W. Chang, Ph.D.)

生理學科暨生理所  教授 分機:5445  Email:aywchang@mail.ncku.edu.tw

專長與研究興趣:

1. 有機磷中毒及解毒機制

2. 成癮藥物中毒致死機制

3. 癲癇猝死機制

4. 神經細胞與膠細胞交互作用參與中風後誘發中樞神經調控循環反應異常之機理

5. 表關基因修飾於上呼吸道消化癌之角色

近五年代表作:

  1. Chuang YC, Chen SD, Lin TK, Chang WN, Lu CH, Liou CW, Chan SHH, **Chang AYW. Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus. Journal of Neuroscience Research, 2010, 88:1898-1907.
  2. Chou JLJ, Wu CHY, Tsai CY, **Chang AYW, Chan SHH. Proteomic investigation of a neural substrate intimately related to brain death. Proteomics, 2011, 11:239-248.
  3. Chan SHH, Chan JYH, Hsu KS, Li FCH, Sun EYH, Chen WL, **Chang AYW. Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in mevinphos intoxication model of brain stem death. British Journal of Pharmacology, 2011, 164:2015-2028.
  4. Li FCH, Yen JC, Chan SHH, **Chang AYW. Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication. PLoS One, 2012, 7:e30589.
  5. Tsai CY, Chan JYH, Hsu KS, **Chang AYW, Chan SHH. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus. PLoS One, 2012, 7:e33527.
  6. Tsai CY, Su CH, Baudrie V, Laude D, Weng JC, Chang AYW, Chan JYH, Elghozi JL, Chan SHH. Visualizing oxidative stress-induced depression of cardiac vagal baroreflex by MRI/DTI in a mouse neurogenic hypertension model. Neuroimage, 2013, 82:190-199.
  7. Li FCH, Li BPT, Wu JY, Wu JCC, **Chang AYW.Transition from oxidative stress to nitrosative stress in rostral ventrolateral medulla underlies fatal intoxication induced by organophosphate mevinphos. Toxicological Sciences, 2013, 135:202-217. (Cover Page )
  8. Tsai CY#, Chang AYW#, Chan JYH, Chan S.H.H. Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication. Biochemical Pharmacology, 2014, 88:75-85. (#:equal contribution)
  9. **Chang AYW, Li FCH, Huang CW, Wu JCC, Dai KY, Chen CH, Li SH, Su CH, Wu RW.Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke. Neurobiology of Diseases, 2014,71:292-304.
  10. Chen YH, Huang CH, Lu HI, Chen CH, Huang WT, Hsieh MJ, Rau KM, Chang AYW, Lin WC,Li SH. Prognostic impact of renin-angiotensin system blockade in esophageal squamous cell carcinoma. Journal of Renin Angiotensin Aldosterone System, 2014 Jun 24. pii: 1470320314535275.
  11. Tsai CY, Chen CH, Chang AYW, Chan JYH, Chan SHH. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. Biochemical Pharmacology, 2015, 93:34-41.
  12. Chen CH, Chang AYW, Li SH, Tsai HT, Shiu LY, Su LJ, Wang WL, Chiu TJ, Luo SD, Huang TL, Chien CY. Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer. Molecular Cancer. 2015, 14:83. doi: 10.1186/s12943-015-0348-7.