首頁師資〉教師指導學生

陳珮君

 

陳珮君  (Chen, Pei-Chun, Ph.D. )

生理所 助理教授 分機: 5423;5427   E-mail:pcchen@mail.ncku.edu.tw

個人網址:http://phys.med.ncku.edu.tw/fac-pcchen.php

研究興趣

 

My general interest is to understand metabolic influence on neuronal activity and its contribution to development of disease. ATP sensitive potassium (KATP) channels are of special interest, because their open probability directly depends on the metabolic state of a cell. KATP channels are closed at high ATP to ADP ratios and open in response to decreased ATP and increased ADP levels. Hence, few projects have been initiated as follows:

  • Effect of leptin on ATP sensitive potassium channel (KATP) and Kv2.1 channel trafficking in pancreatic beta cells and hypothalamic neurons
  • To discover the role of surface and mitochondrial KATP channels in dopaminergic neurodegeneration
  • The role of oxidative DNA damage and repair in striatal neurodegeneration (In collaboration with Dr. Marcus Calkins in the Graduate Institute of Clinical Medicine)

 

近五年代表作

 

  1. Q. Zhou, P.C. Chen, P.K. Devaraneni, G.M. Martin, E.M. Olson, S.L. Shyng (2014), Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin) May 21; 8 (4) [ Epub aheard of print]
  2. G. Martin, P.C. Chen, P. Devaraneni, S.L. Shyng, (2013), Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels. Front Physiol. Dec 24;4:386. eCollection. PMID:24399968
  3. P.C. Chen, Y. Kryukova, S.L. Shyng, (2013), Leptin regulates KATP channel trafficking in pancreatic b-cells by a signaling mechanism involving AMPK and PKA to the plasma membrane. J Biol Chem 288:34098-34109. "Paper of the Week." And A figure from the paper was selected for the Nov. 22 cover of JBC
  4. P.C. Chen , E. Olson, Q. Zhou , Y. Kryukova , H. Sampson ,D.Y. Thomas, S.L. Shyng (2013), Carbamazepine as a Novel Small Molecule Corrector of Trafficking-Impaired ATP-Sensitive Potassium Channels Identified in Congenital Hyperinsulinism, J Biol Chem 288:20942-20954.
  5. H.M. Sampson, H. Lam, P.C. Chen, D. Zhang, C. Mottillo, M. Mirza, K. Qasim, A. Shrier, S.L. Shyng, J.W. Hanrahan, D.Y. Thomas (2013), Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an invitro study using cell lines, Orphanet J Rare Dis. 8:11.
  6. C. Escartin, S. Joon Won, C. Malgorn, G. Auregan G, A.E. Berman , P.C. Chen, N. Déglon, J.A. Johnson,S. Won Suh, R.A. Swanson (2011), Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino Acid transporter 3 expression, J Neurosci. 31:7392-7401.
  7. P.C. Chen, C.E. Bruederle, H.Y. Gaisano, S.L. Shyng (2011), Syntaxin 1A regulates processing and endocytic trafficking of pancreatic ATP-sensitive potassium Channels, Am. J. Physiol. Cell Physiol. 300: C506-C516.
  8. F.F. Yan, E.B. Pratt, P.C. Chen, F. Wang, W.R. Skach, L.L. David, S.L. Shyng (2010), Role of HSP90 in biognenesis of the β-CELL ATP-sensitive potassium channel complex, Mol. Biol. Cell. 21: 1945-1954.
  9. P.C. Chen, C.L. Lao and J.C. Chen (2009), The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5., J. Neurochem. 110: 1180-1190.
  10. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson (2009), Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte, Proc. Natl. Acad. Sci. USA. 106: 2933-2938.