姜學誠

姜學誠(HSUEHCHENG CHIANG)  

藥理學研究所  助理教授  分機：5497　Email:chianghc@mail.ncku.edu.tw.

專長與研究興趣:

1. 動物行為學：以果蠅為動物模式探討老年痴呆症的分子機制，主要利用乙型－澱粉樣蛋白（beta amyloid)轉基因果蠅去了解乙型－澱粉樣蛋白在疾病過程中如何造成學習與記憶喪失及細胞死亡
2. 細胞影像學：研究細胞是如何釋放及接受傳導物質，主要用分泌型細胞株探討傳導物質釋放的分子調控機理。

近五年代表作:

1. Wu CL, Chang CC, Wu JK, Chiang MH, Yang CH, Chiang HC. Mushroom body glycolysis is required for olfactory memory in Drosophila. Neurobiol Learn Mem. 2018 Feb 22;150:13-19.
2. Cheng KC, Chiang HC. XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology. Mol Neurobiol. 2018 Feb 9. doi: 10.1007/s12035-018-0942-y.
3. Ji XR, Cheng KC, Chen YR, Lin TY, Cheung CHA, Wu CL, Chiang HC. Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies. FASEB J. 2018 Mar;32(3):1375-1387
4. Zhao WD, Hamid E, Shin W, Wen PJ, Krystofiak ES, Villarreal SA, Chiang HC, Kachar B, Wu LG. Hemi-fused structure mediates and controls fusion and fission in live cells. Nature. 2016 Jun 23;534(7608):548-52.
5. Chiang HC, Shin W, Zhao WD, Hamid E, Sheng J, Baydyuk M, Wen PJ, Jin A, Momboisse F, and Wu LG. Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nature Commun. 2014, 5:3356
6. Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG.Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol. 2014 Jan;16(1):55-65.
7. Xue L, Sheng J, Wu XS, Wu W, Luo F, Shin W, Chiang HC, Wu LG. Most vesicles in a central nerve terminal participate in recycling. J Neurosci. 2013 33(20):8820-6.
8. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W, Wu LG. SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapses. Cell Rep. 2013 3(5):1414-21.
9. Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, Zhong Y.Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.Proc Natl Acad Sci U S A. 2012 109(41):16743-8.  Co-first author
10. Chiang HC, Wang L, Xie Z, Yau A, Zhong Y. PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila. Proc Natl Acad Sci U S A. 2010 107(15):7060-5.
11. Chiang HC, Iijima K, Hakker I, Zhong Y. Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions. FASEB J. 2009 23(6):1969-77.