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姜學誠

姜學誠(HSUEHCHENG CHIANG)  

藥理學研究所  助理教授  分機：5497　Email:chianghc@mail.ncku.edu.tw.

專長與研究興趣:

  1. 動物行為學：以果蠅為動物模式探討老年痴呆症的分子機制，主要利用乙型－澱粉樣蛋白（beta amyloid)轉基因果蠅去了解乙型－澱粉樣蛋白在疾病過程中如何造成學習與記憶喪失及細胞死亡
  2. 細胞影像學：研究細胞是如何釋放及接受傳導物質，主要用分泌型細胞株探討傳導物質釋放的分子調控機理。

近五年代表作:

  1. Chiang HC, Shin W, Zhao WD, Hamid E, Sheng J, Baydyuk M, Wen PJ, Jin A, Momboisse F, and Wu LG. Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nature Commun. 2014, 5:3356
  2. Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG.Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat Cell Biol. 2014 Jan;16(1):55-65.
  3. Xue L, Sheng J, Wu XS, Wu W, Luo F, Shin W, Chiang HC, Wu LG. Most vesicles in a central nerve terminal participate in recycling. J Neurosci. 2013 33(20):8820-6.
  4. Xu J, Luo F, Zhang Z, Xue L, Wu XS, Chiang HC, Shin W, Wu LG. SNARE proteins synaptobrevin, SNAP-25, and syntaxin are involved in rapid and slow endocytosis at synapses. Cell Rep. 2013 3(5):1414-21.
  5. Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, Zhong Y.Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.Proc Natl Acad Sci U S A. 2012 109(41):16743-8.  Co-first author
  6. Chiang HC, Wang L, Xie Z, Yau A, Zhong Y. PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila. Proc Natl Acad Sci U S A. 2010 107(15):7060-5.
  7. Chiang HC, Iijima K, Hakker I, Zhong Y. Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions. FASEB J. 2009 23(6):1969-77.