首頁師資〉教師指導學生

陳韻雯

陳韻雯 (Chen Yun-Wen, Ph.D.)

藥理所 助理教授      分機:5503  E-mail: yunwen_chen@mail.ncku.edu.tw

研究興趣

探討人類新陳代謝疾病 (Insulin resistance、糖尿病及其引起之併發症等 ) 之分子病理機轉。主要研究主題為:

  1. 胰島素抵抗和β細胞缺陷
  2. 週邊組織血清素系統在代謝體內平衡扮演的角色
  3. RNA編輯對人類代謝疾病之影響
  4. 代謝疾病與情緒障礙之間的相關性

研究方法: 細胞培養、基因轉殖、細胞和分子生物學技術及動物模式

近五年代表作

  1. Chang HY, Chen SL, Shen MR, Kung ML, Chuang LM, Chen YW: Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells, Sci Rep.2017 (in revision)
  2. Kung ML, Tai MH, Lin PY, Wu DC, Wu WJ, Yeh BW, Hung HS, Kuo CH, Chen YW, Hsieh SH, Hsieh SC:Silver Decorated Copper Oxide (Ag@CuO) Nanocomposite Enhances ROS-mediated Bacterial Architecture Collapse, Colloids Surf B Biointerfaces. 2017 (accepted)
  3. Chen YW, Chang CW, Hung HS, Kung ML, Yeh BW, Hsieh SC: Magnetite nanoparticle interactions with insulin amyloid fibrils, Nanotechnology. 2016, 27 (41):415702
  4. Chen YW, Chen YF, Chen YT, Chiu WT, Shen MR: The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition, Sci Rep.2016, 26 (6): 22142
  5. Hsieh SC, Chen HJ, Hsu SH, Yang YC, Tang CM, Chu MY, Lin PY, Fu RH, Kung ML, Chen YW, Yeh BW, Hung HS: Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen–Gold Nanocomposites. ACS Applied Materials & Interfaces, 2016, 8 (42): 28982–29000
  6. Liu C*, Suksanpaisan L*, Chen YW* , Russell SJ, Peng KW. (2013) Enhancing Cytokine Induced Killer Cell Therapy of Multiple Myeloma, Exp Hematol. 2013 Feb 8. doi:pii: S0301-472X(13)00014-3. 10.1016/j.exphem.2013.01.010. [Epub ahead of print] (*equal authorship)
  7. Chang SY*, Chen YW*, Zhao XP, Chenier I, Tran S, Sauve A, Ingelfinger JR, Chan JS, Zhang SL: Catalase Prevents Maternal Diabetes-Induced Perinatal Programming via the Nrf2-HO-1 Defense System, Diabetes, 2012 Oct; 61 (10): 2565-74. Epub 2012 Jun 25 (*equal authorship)
  8. Chang SY,Chen YW, Chenier I, Tran S, Zhang SL: Angiotensin II Type II Receptor Deficiency Accelerates the Development of Nephropathy in Type I Diabetes via Oxidative Stress and ACE2. Exp. Diabetes. Res. 2011:521076. Epub 2011 Oct 27 (IF: 1.2)
  9. Chen YW, Chang SY, Scotcher M, Chenier I, Zhang SL: High Glucose Promotes Nascent Nephron Apoptosis Via p53 and NF-KB Pathway. Am J Physiol Renal Physiol. 2011 Jan; 300(1): F147-56 (IF: 3.682)
  10. Chen YW, Chenier I, Tran S, Scotcher M, Chang SY, Zhang SL: Maternal Diabetes Programs Hypertension and Kidney Injury in Offspring. Pediatric Nephrology, 2010 Jul; 25(7): 1319-29 (IF: 2.518)
  11. Chen YW, Chang SY, Scotcher M, Chenier I, Zhang SL: High Glucose Promotes Nascent Nephron Apoptosis Via p53 and NF-KB Pathway. Am J Physiol Renal Physiol. 2011 Jan; 300(1): F147-56 (IF: 3.682)
  12. Chen YW, Tran S, Chenier I, Ingelfinger JR, Zhang SL: Deficiency of intrarenal AT2R impairs Pax2/N-myc Expression during Nephrogenesis. Pediatric Nephrology. 2008 Oct; 23(10): 1769-77 (IF: 2.518)
  13. Zhang SL, Chen YW, Tran S, Chenier I, Hébert MJ, Ingelfinger JR: Reactive Oxygen Species in the presence of High Glucose Alter Ureteric Bud Morphogenesis. J Am Soc Nephrol. 18(7): 2105-2115, 2007 (IF: 9.663)
  14. Zhang SL, Chen YW, Tran S, Liu F, Nestoridi E, Hébert MJ, Ingelfinger JR: Pax-2 And N-myc, Regulate Epithelial Cell Proliferation and Apoptosis in a Positive Autocrine feedback loop. Pediatric Nephrology. 22(6): 813-824, 2007 (IF: 2.518)
  15. Chen YW, Liu F, Tran S, Zhu Y.H., Hébert, MJ, Ingelfinger JR, Zhang SL:Reactive Oxygen Species (ROS) and NF-kB Pathway Mediate High Glucose- Induced Pax-2 Gene Expression in Mouse Embryonic Mesenchymal Epithelial Cells and Kidney Explants. Kidney Int.70 (9): 1607-1615, 2006 (IF: 6.606)
  16. Wei CC, Zhang SL, Chen YW, Guo DF, Ingelfinger JR, Bomszytyk K, Chan JS: Heterogenous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells. J Biol Chem, 281(35): 25344-25355, 2006 (IF: 4.773) 12 Jun 25 (*equal authorship)