首頁師資〉專/兼任師資專長

陳韻雯

陳韻雯  (Chen Yun-Wen, Ph.D.)

藥理所 助理教授      分機:5503   E-mail: yunwen_chen@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~pharma/v2011/staff/6.html

研究興趣

探討人類新陳代謝疾病 (Insulin resistance、糖尿病及其引起之併發症等 ) 之分子病理機轉。主要研究主題為:

(1) 妊娠糖尿病對胎兒腎臟發育的影響

(2) 糖尿病腎病變

(3) 胰島素抵抗及 beta 細胞分泌缺陷

研究方法: 細胞培養、基因轉殖、DNA microarray 及動物模式等方法

近五年代表作

  1. Liu C*, Suksanpaisan L*, Chen YW* , Russell SJ, Peng KW. (2013) Enhancing Cytokine Induced Killer Cell Therapy of Multiple Myeloma, Exp Hematol. 2013 Feb 8. doi:pii: S0301-472X(13)00014-3. 10.1016/j.exphem.2013.01.010. [Epub ahead of print] (*equal authorship)
  2. Chang SY*, Chen YW*, Zhao XP, Chenier I, Tran S, Sauve A, Ingelfinger JR, Chan JS, Zhang SL: Catalase Prevents Maternal Diabetes-Induced Perinatal Programming via the Nrf2-HO-1 Defense System, Diabetes, 2012 Oct; 61 (10): 2565-74. Epub 2012 Jun 25 (*equal authorship)
  3. Chang SY,Chen YW, Chenier I, Tran S, Zhang SL: Angiotensin II Type II Receptor Deficiency Accelerates the Development of Nephropathy in Type I Diabetes via Oxidative Stress and ACE2. Exp. Diabetes. Res. 2011:521076. Epub 2011 Oct 27 (IF: 1.2)
  4. Chen YW, Chang SY, Scotcher M, Chenier I, Zhang SL: High Glucose Promotes Nascent Nephron Apoptosis Via p53 and NF-KB Pathway. Am J Physiol Renal Physiol. 2011 Jan; 300(1): F147-56 (IF: 3.682)
  5. Chen YW, Chenier I, Tran S, Scotcher M, Chang SY, Zhang SL: Maternal Diabetes Programs Hypertension and Kidney Injury in Offspring. Pediatric Nephrology, 2010 Jul; 25(7): 1319-29 (IF: 2.518)
  6. Chen YW, Chang SY, Scotcher M, Chenier I, Zhang SL: High Glucose Promotes Nascent Nephron Apoptosis Via p53 and NF-KB Pathway. Am J Physiol Renal Physiol. 2011 Jan; 300(1): F147-56 (IF: 3.682)
  7. Chen YW, Tran S, Chenier I, Ingelfinger JR, Zhang SL: Deficiency of intrarenal AT2R impairs Pax2/N-myc Expression during Nephrogenesis. Pediatric Nephrology. 2008 Oct; 23(10): 1769-77 (IF: 2.518)
  8. Zhang SL, Chen YW, Tran S, Chenier I, Hébert MJ, Ingelfinger JR: Reactive Oxygen Species in the presence of High Glucose Alter Ureteric Bud Morphogenesis. J Am Soc Nephrol. 18(7): 2105-2115, 2007 (IF: 9.663)
  9. Zhang SL, Chen YW, Tran S, Liu F, Nestoridi E, Hébert MJ, Ingelfinger JR: Pax-2 And N-myc, Regulate Epithelial Cell Proliferation and Apoptosis in a Positive Autocrine feedback loop. Pediatric Nephrology. 22(6): 813-824, 2007 (IF: 2.518)
  10. Chen YW, Liu F, Tran S, Zhu Y.H., Hébert, MJ, Ingelfinger JR, Zhang SL:Reactive Oxygen Species (ROS) and NF-kB Pathway Mediate High Glucose- Induced Pax-2 Gene Expression in Mouse Embryonic Mesenchymal Epithelial Cells and Kidney Explants. Kidney Int.70 (9): 1607-1615, 2006 (IF: 6.606)
  11. Wei CC, Zhang SL, Chen YW, Guo DF, Ingelfinger JR, Bomszytyk K, Chan JS: Heterogenous nuclear ribonucleoprotein K modulates angiotensinogen gene expression in kidney cells. J Biol Chem, 281(35): 25344-25355, 2006 (IF: 4.773) 12 Jun 25 (*equal authorship) .