首頁師資〉專/兼任師資專長

張志鵬

 

張志鵬 (Chih-Peng Chang, Ph.D.)

微免所 助理教授   分機:5643     E-mail: cpchang@mail.ncku.edu.tw

個人網址: http://www.ncku.edu.tw/~microbio/teacher/cccp.htm

研究興趣

細胞自噬是一個演化上高度保存的溶酶體依賴系統,在真核生物中用以調節細胞的蛋白質和細胞器的衡定。此系統已被證明能控制不同的細胞功能,包括誘導細胞死亡,免疫激活作用,消除病原體和癌症的產生。我的研究興趣主要是探討細胞自噬作用如何調節肝癌腫瘤免疫和治療的相關應用,以及在登革熱病毒感染中的角色。實驗室目前主要方向為:

1. 外源凝集素誘導的細胞自噬作用在肝癌治療和化療抗性的探討

2. 細胞自噬作用在調節肝癌相關巨噬細胞功能和腫瘤免疫的角色

3. 細胞自噬相關蛋白和登革熱病毒蛋白的相互作用

近五年代表作

  1. Hung LY, Chang JC, Tsai YC, Huang CC, Chang CP, Yeh CS, Lee GB*. Magnetic nanoparticle-based immunoassay for rapid detection of influenza infections by using an integrated microfluidic system. Nanomedicine. 2014 ;10(4):819-29
  2. Tai CH, Tsai YC, Wang CH, Ho TS, Chang CP*, Lee GB*. An integrated microfluidic platform for rapid detection and subtyping of influenza viruses from clinical samples. Microfluid Nanofluidics 2014, 16(3): 501-512
  3. Chen MH, Li WS, Lue YS, Chu CL, Pan IH, Ko CH, Chen DY, Lin CH, Lin SH, Chang CP, Lin CC*. Clitocybe nuda Activates Dendritic Cells and Acts as a DNA Vaccine Adjuvant. Evid Based Complement Alternat Med 20132013;2013:761454.
  4. Chang CP*, Su YC, Lee PH, Lei HY. Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation. Autophagy. 2013; 9(4): 1–3.
  5. Chang CP*, Su YC, Hu CW and Lei HY. TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation. Cell Death Differ. 2013; 20(3):515-23.
  6. Chuang YC, Su WH, Lei HY, Lin YS, Liu HS, Chang CP, Yeh TM. Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation. PLoS One. 2012;7(5):e37613.
  7. Chang CP, Yang MC, Lei HY*. Concanavalin A/IFN-g triggers autophagy-related necrotic hepatocyte death through immunity-related GTPase family M member 1-mediated lysosomal membrane disruption. PLoS One. 2011;6(12):e28323.
  8. Yang MC, Chang CP, Lei HY*. Induction of liver fibrosis in a murine hepatoma model by thioacetamide is associated with enhanced tumor growth and suppressed antitumor immunity. Lab Invest. 2010 ;90(12):1782-93.
  9. Yang MC, Chang CP, Lei HY*. Endothelial cells are damaged by autophagic induction before hepatocytes in Con A-induced acute hepatitis. Int Immunol. 2010 ;22(8):661-70.