首頁師資〉專/兼任師資專長

彭貴春

彭貴春 (Guey-Chuen Perng, Ph.D.)

微免所 副教授   分機:5626     E-mail: gperng@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~microbio/teacher/cpgc.htm

專長說明:

傳染性疾病對各國政府的公共衛生體系都造成一個沉重的經濟負擔,在已開發與開發中國家中因為對公共衛生的認知與公衛體系的建構較為完善,傳染性疾病造成的問題較為輕微。但是在未開發國家中,因為面對社會文化的差異與政府經費有限的現實,在政府天天面對的許多棘手議題中,處理傳染性疾病這單一問題就顯得困難許多。因此,傳染性疾病是最有可能被犧牲而忽略掉的,特別是地方性傳染病僅侷限在某一特定區域,在開發中國家很可能被忽視,其中一個被輕忽的疾病是登革熱,它是一種藉由攜帶登革病毒的蚊子進行傳播的疾病,儘管登革熱已在許多地方傳播開來,在熱帶與亞熱帶地區仍較為盛行.

♣ 研究焦點在瞭解病毒感染造成疾病的致病機制與先天性宿主免疫的反應機制

♣ 分析登革病毒造成嚴重疾病後果的病毒與宿主易感因子之間的交互作用(Dissecting the dynamic interactions between viruses and a susceptible host factor, which may result in a dire consequence, is the methodological approach to achieve the goal)

♣以登革病毒作為研究模式的目標:登革熱是一種急性的與時序性的傳染病,病人在發病幾天內可能因為缺乏及早診斷與適時的照護而身體非常不適。登革熱比較特別與潛在致命的臨床特徵是血漿滲漏與休克,而導致此現象的機制目前尚不清楚。血小板缺乏症是一個在登革熱病人特別突顯的臨床症狀,但是其形成的機制尚待釐清。在由登革熱病人分離出的血小板中可以觀察到登革病毒顆粒,我們的研究聚焦在探索造成血小板缺乏症的機制,包含研究血小板的前驅細胞巨核細胞在登革病毒致病機制中所扮演的角色。

v  瞭解導致血小板缺乏症的可能機制

v  鑑定人體內登革病毒感染的標的細胞

v  瞭解為何在中和性抗體存在的情況下登革熱病人再次感染登革病毒病毒血症仍然會再次的發生

v  研究微顆粒在登革致病機制中所扮演的角色

v  在急性登革病毒感染中記憶性B細胞的角色

發展一套可以用來探討臨床上登革出血熱病人發病機制的模擬人體之動物模式

近五年代表作

  1. Khin Saw Aye Myint, Anja Kipar, Richard G. Jarman, Robert V. Gibbons, Guey Chuen Perng, Brian Flanagan, Duangrat Mongkolsirichaikul, Yvonne Van Gessel, and Tom Solomon. Neuropathogenesis of Japanese encephalitis in a primate model. PLoS Negl Trop Dis 2014, 8(8): e2980.
  2. Kwissa M, Nakaya HI, Onlamoon N, Wrammert J, Villinger F, Perng Guey Chuen, Yoksan S, Pattanapanyasat K, Chokephaibulkit K, Ahmed R, Pulendran B. Dengue Virus Infection Induces Expansion of a CD14(+)CD16(+) Monocyte Population that Stimulates Plasmablast Differentiation. Cell Host Microbe. 2014 Jul 9;16(1):115-27.
  3. Konstantin Tsetsarkin, Rubing Chen, Ruimei Yun, Shannan Rossi, Kenneth Plante, Mathilde Guerbois, Naomi Forrester, Guey Chuen Perng, Easwaran Sreekumar, Grace Leal, Jing Huang, Suchetana Mukhopadhyay, and Scott Weaver. Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. Nat Commun. 2014 Jun 16;5:4084.
  4. Yao HW, Lin PH, Shen FH, Perng GC, Tung YY, Hsu SM, Chen SH. Tranylcypromine Reduces Herpes Simplex Virus 1 Infection in Mice. Antimicrob Agents Chemother. 2014, 58(5):2807-15.
  5. Tsai JJ, Chokephaibulkit K, Chen PC, Liu LT, Hsiao HM, Lo YC, and Perng Guey Chuen. 2013. Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. J Biomed Sci. 2013, 20:88.
  6. Clark KB, Onlamoon N, Hsiao HM, Perng Guey Chuen, and Villinger F. 2013. Can non-human primates serve as models for investigating dengue disease pathogenesis? Front Microbiol. 2013, 4:305.
  7. Jih-Jin Tsai, Po-Chih Chen, Li-Teh Liu, Ko Chang, Ju-Han Yao, Hui-Mien Hsiao, Kristina B Clark, Yu Han Chen, Alan Yi-Hui Hsu and Guey Chuen Perng. 2013. Pathogenic Parameters Derived from Activated Platelets in Dengue Patients. Trop Med Surg. 2013, 1:5.
  8. Jih-Jin Tsai, Min-Han Hsieh, Li-The Liu, Hui-Mien Hsiao, and Guey Chuen Perng. 2013. Mortality from septic shock in a dengue infected patient: a case report. Southeast Asian J. Trop. Med. Public Health. 2013, 44:623-629.
  9. Kulkanya Chokephaibulkit and Guey Chuen Perng. 2013. Challenges for the formulation of a universal vaccine against dengue. Experimental Biology and Medicine. 2013, 238: 566–578.
  10. Guey Chuen Perng and Kulkanya Chokephaibulkit. 2013. Immunologic hypo- or non-responder in natural dengue virus infection. J Biomed Sci. 2013, 20:34.
  11. Guey Chuen Perng. 2012.Editorial: Role of bone marrow in pathogenesis of viral infection. J. Bone Marrow Res. 2012,1:e102.
  12. Kristina B Clark, Sansanee Noisakran, Hui-Mien Hsiao, John Roback, Francois Villinger, Aftab A Ansari, and Guey Chuen Perng. 2012. Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow. PloS One. 2012, 7:e52902.
  13. Sansanee Noisakran, Nattawat Onlamoon, Kovit Pattanapanyasat, Hui-Mien Hsiao, Pucharee Songprakhon, Nasikarn Angkasekwinai, Kulkanya Chokephaibulkit, Francois Villinger, Aftab A. Ansari, and Guey Chuen Perng. 2012. Role of CD61+ cells in thrombocytopenia of dengue patients. International Journal of Hematology. 96:600-10.
  14. Kristina Bargeron Clark, Hui-Mien Hsiao, Sansanee Noisakran, Jih-Jin Tsai, and Guey Chuen Perng. 2012. Role of microparticles in dengue virus infection and its impact on medical intervention strategies. Yale Journal of Biology and Medicine. 2012, 85:3-18.
  15. Wrammert J, Onlamoon N, Akondy RS, Perng GC, Polsrila K, Chandele A, Kwissa M, Pulendran B, Wilson P, Wittawatmongkol O, Yoksan S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Ahmed R. 2012. Rapid and massive virus specific plasmablast responses during acute dengue virus1012. infection in humans. J Virol. 2012, 86:2911-8.
  16. Sansanee Noisakran, Nattawat Onlamoon, Hui-Mien Hsiao, Kristina B. Clark, Francois Villinger, Astab Ansari, and Guey Chuen Perng. 2012. Infection of Bone Marrow Cells by Dengue Virus In Vivo. Exp Hematol. 2012, 40:250-259
  17. .Guey Chuen Perng, Huan-Yao Lei, Yee-Shin Lin, and Kulkanya Chokephaibulkit. 2011. Dengue Vaccines: Challenge and Confrontation. World Journal of Vaccines.2011,1:109-130.
  18. Kulkanya Chokephaibulkit and G. C. Perng. 2011. The Importance of Temperature for Medical Science. Current Topics In Virology. 2011, 9: 43-49.
  19. Jih-Jin Tsai, Li-The Liu, Ko Chang, Shu-Hui Wang, Hui-Mie hsiao, Kristina B. Clark and G. C. Perng. 2011. The importance of hematopoietic progenitor cells in dengue. Therapeutic Advances in Hematology.2011, 3: 59-71.
  20. Jih-Jin Tsai, Yen-Hua Jen, Jung-San Chang, Hui-Mien Hsiao, Sansanee Noisakran, and G. C. Perng. 2011. Frequency alterations in key innate immune cell components in peripheral blood of dengue patients detected by FACS analysis. J Innate Immun. 2011. 3:530-40.