首頁師資〉專/兼任師資專長

彭貴春

彭貴春 (Guey Chuen Perng, Ph.D.)

微免所 教授 分機:5626     E-mail: gperng@mail.ncku.edu.tw

個人網頁:http://www.ncku.edu.tw/~microbio/teacher/cpgc.htm

研究興趣

1. 傳染性疾病對各國政府的公共衛生體系都造成一個沉重的經濟負擔,在已開發與開發中國家中因為對公共衛生的認知與公衛體系的建構較為完善,傳染性疾病造成的問題較為輕微。但是在未開發國家中,因為面對社會文化的差異與政府經費有限的現實,在政府天天面對的許多棘手議題中,處理傳染性疾病這單一問題就顯得困難許多。因此,傳染性疾病是最有可能被犧牲而忽略掉的,特別是地方性傳染病僅侷限在某一特定區域,在開發中國家很可能被忽視,其中一個被輕忽的疾病是登革熱,它是一種藉由攜帶登革病毒的蚊子進行傳播的疾病,儘管登革熱已在許多地方傳播開來,在熱帶與亞熱帶地區仍較為盛行.

2. 研究焦點在瞭解病毒感染幹細胞暨前驅細胞造成疾病的致病機制與先天性宿主免疫的反應機制

3. 分析登革病毒造成嚴重疾病後果的病毒與宿主易感因子之間的交互作用

4. 以登革病毒作為研究幹細胞暨前驅細胞分化和分裂的模式

近五年代表作

  1. JJ Tsai, JS Chang, K Chang, PC Chen, LT Liu, TC Ho, SS Tan, YW Chien, YC Lo, and GC Perng. (2017). Transient monocytosis subjugates low platelet count in adult dengue patients. Biomedicine Hub: e457785.
  2. Wu YW, Mettling C, Wu SR, Yu CY, Perng GC, Lin YS, Lin YL. (2016). Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization. Sci Rep. 6:32243.
  3. Chen HR, Chuang YC, Lin YS, Liu HS, Liu CC, Perng GC, Yeh TM. (2016 Jul ) Dengue Virus Nonstructural Protein 1 Induces Vascular Leakage through Macrophage Migration Inhibitory Factor and Autophagy. PLoS Negl Trop Dis. 13;10(7):e0004828.
  4. Lo YC, Perng GC. (2016 Jun) Novel concept on antiviral strategies to dengue. Curr Opin Virol. 18:97-108.
  5. Clark KB, Hsiao HM, Bassit L, Crowe JE Jr, Schinazi RF, Perng GC, Villinger F. Characterization of dengue virus 2 growth in megakaryocyte-erythrocyte progenitor cells.Virology. 2016 Apr 5;493:162-172.
  6. Hsu AY, Wu SR, Tsai JJ, Chen PL, Chen YP, Chen TY, Lo YC, Ho TC, Lee M, Chen MT, Chiu YC, Perng GC. Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance. Sci Rep. 2015 Dec 11;5:17990. doi: 10.1038/srep17990.
  7. Jester JV, Morishige N, BenMohamed L, Brown DJ, Osorio N, Hsiang C, Perng GC, Jones C, Wechsler SL. Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. Cornea. 2016, Jan;35(1):81-8.
  8. John DV, Lin YS, Perng GC. Biomarkers of severe dengue disease - a review. J Biomed Sci. 2015 Oct 14;22(1):83.
  9. Solbrig MV, Perng GC. Current neurological observations and complications of dengue virus infection. Curr Neurol Neurosci Rep. 2015 Jun;15(6):550.
  10. Perng GC, Osorio N, Jiang X, Geertsema R, Hsiang C, Brown D, BenMohamed L, Wechsler SL. Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. Curr Eye Res. 2015 Apr 10:1-8.
  11. Khin Saw Aye Myint, Anja Kipar, Richard G. Jarman, Robert V. Gibbons, Guey Chuen Perng, Brian Flanagan, Duangrat Mongkolsirichaikul, Yvonne Van Gessel, and Tom Solomon. Neuropathogenesis of Japanese encephalitis in a primate model. PLoS Negl Trop Dis 2014, 8(8): e2980.
  12. Kwissa M, Nakaya HI, Onlamoon N, Wrammert J, Villinger F, Perng Guey Chuen, Yoksan S, Pattanapanyasat K, Chokephaibulkit K, Ahmed R, Pulendran B. Dengue Virus Infection Induces Expansion of a CD14(+)CD16(+) Monocyte Population that Stimulates Plasmablast Differentiation. Cell Host Microbe. 2014 Jul 9;16(1):115-27.
  13. Konstantin Tsetsarkin, Rubing Chen, Ruimei Yun, Shannan Rossi, Kenneth Plante, Mathilde Guerbois, Naomi Forrester, Guey Chuen Perng, Easwaran Sreekumar, Grace Leal, Jing Huang, Suchetana Mukhopadhyay, and Scott Weaver. Multi-peaked adaptive landscape for chikungunya virus evolution predicts continued fitness optimization in Aedes albopictus mosquitoes. Nat Commun. 2014 Jun 16;5:4084.
  14. Yao HW, Lin PH, Shen FH, Perng GC, Tung YY, Hsu SM, Chen SH. Tranylcypromine Reduces Herpes Simplex Virus 1 Infection in Mice. Antimicrob Agents Chemother. 2014, 58(5):2807-15.
  15. Tsai JJ, Chokephaibulkit K, Chen PC, Liu LT, Hsiao HM, Lo YC, and Perng Guey Chuen. 2013. Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. J Biomed Sci. 2013, 20:88.
  16. Clark KB, Onlamoon N, Hsiao HM, Perng Guey Chuen, and Villinger F. 2013. Can non-human primates serve as models for investigating dengue disease pathogenesis? Front Microbiol. 2013, 4:305.
  17. Jih-Jin Tsai, Po-Chih Chen, Li-Teh Liu, Ko Chang, Ju-Han Yao, Hui-Mien Hsiao, Kristina B Clark, Yu Han Chen, Alan Yi-Hui Hsu and Guey Chuen Perng. 2013. Pathogenic Parameters Derived from Activated Platelets in Dengue Patients. Trop Med Surg. 2013, 1:5.
  18. Jih-Jin Tsai, Min-Han Hsieh, Li-The Liu, Hui-Mien Hsiao, and Guey Chuen Perng. 2013. Mortality from septic shock in a dengue infected patient: a case report. Southeast Asian J. Trop. Med. Public Health. 2013, 44:623-629.
  19. Kulkanya Chokephaibulkit and Guey Chuen Perng. 2013. Challenges for the formulation of a universal vaccine against dengue. Experimental Biology and Medicine. 2013, 238: 566–578.
  20. Guey Chuen Perng and Kulkanya Chokephaibulkit. 2013. Immunologic hypo- or non-responder in natural dengue virus infection. J Biomed Sci. 2013, 20:34.
  21. Guey Chuen Perng. 2012. Editorial: Role of bone marrow in pathogenesis of viral infection. J. Bone Marrow Res. 2012,1:e102.
  22. Kristina B Clark, Sansanee Noisakran, Hui-Mien Hsiao, John Roback, Francois Villinger, Aftab A Ansari, and Guey Chuen Perng. 2012. Multiploid CD61+ cells are the pre-dominant cell lineage infected during acute dengue virus infection in bone marrow. PloS One. 2012, 7:e52902.
  23. Sansanee Noisakran, Nattawat Onlamoon, Kovit Pattanapanyasat, Hui-Mien Hsiao, Pucharee Songprakhon, Nasikarn Angkasekwinai, Kulkanya Chokephaibulkit, Francois Villinger, Aftab A. Ansari, and Guey Chuen Perng. 2012. Role of CD61+ cells in thrombocytopenia of dengue patients. International Journal of Hematology. 96:600-10.
  24. Kristina Bargeron Clark, Hui-Mien Hsiao, Sansanee Noisakran, Jih-Jin Tsai, and Guey Chuen Perng. 2012. Role of microparticles in dengue virus infection and its impact on medical intervention strategies. Yale Journal of Biology and Medicine. 2012, 85:3-18.
  25. Wrammert J, Onlamoon N, Akondy RS, Perng GC, Polsrila K, Chandele A, Kwissa M, Pulendran B, Wilson P, Wittawatmongkol O, Yoksan S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Ahmed R. 2012. Rapid and massive virus specific plasmablast responses during acute dengue virus1012. infection in humans. J Virol. 2012, 86:2911-8.