首頁師資〉專/兼任師資專長

張雋曦

張雋曦  (Cheung, Chun Hei Antonio, Ph.D., MRSNZ)

藥理所 助理教授     分機:5483 E-mail: acheung@mail.ncku.edu.tw

個人網頁:http://www.ncku.edu.tw/~pharma/v2011/staff/13.html

研究興趣

1. 抗癌藥物的研究:

    研發新穎的存活素(survivin)標靶藥物 - 奈米化顯性負性存活素蛋白(nanoparticle encapsulated dominant-negative survivin protein) 。

2. 癌症基因的研究:

存活素對DNA損傷修復之分子機制探討。

3. 乳癌的研究:

研發在雌激素受體陽性乳癌治療上能取代 Tamoxifen 的新藥物

近五年代表作:

1.  MS Coumar, FY Tsai, JR Kanwar, S Sarvagalla and CHA Cheung* (2013) Treat cancers by targeting survivin: just a dream or future reality? (Review); Cancer Treat. Rev. (In press)

2.   L Ma, H Qiao, Q Yang, C He, X Jiang, CHA Cheung, JR Kanwar and X Sun* (2012) Modulating the interaction of CXCR4 and SDF-1α by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer. Invest. New Drugs. 30:508-517.

3.   KL Chen, WS Chang, CHA Cheung, CC Lin, CC Huang, YN Yang, CP Kuo, CC Kuo, YH Chang, KJ Liu, CM Wu and JY Chang* (2012) Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway. Cancer Lett. 317(1):89-98

4.   Cheung CHA, Lin WH, Hsu JT, Hour TC, Yeh TK, Ko S, Lien TW, Coumar MS, Liu JF, Lai WY, Shiao HY, Lee TR, Hsieh HP, Chang JY* (2011) BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells. PLoS One. 6(8):e23485.

5.   Cheung CHA, Cheng L, Chang KY, Chen HH, Chang JY* (2011) Investigations of survivin: the past, present and future (Review). Front Biosci. 16:952-61.

6.   Cheung CHA, Wu SY, Lee TR, Chang CY, Wu JS, Hsieh HP, Chang JY* (2010) Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes. PLoS One. 5(9):e12564.

7.   Cheung CHA, Chen HH, Cheng LT, Lyu KW, Kanwar JR, Chang JY* (2010) Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells. Mol Cancer. 15;9:77.

8.   Cheung CHA, Chen HH, Kuo CC, Chang CY, Coumar MS, Hsieh HP, Chang JY* (2009) Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers. Mol Cancer. 3;8:43.