首頁師資〉教師指導學生

黃一修

黃一修  (I-Hsiu Huang, Ph.D.)

微免所 助理教授   分機:5582     E-mail: ihsiuhuang@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~microbio/teacher/chis.htm

研究興趣

1. Identification of novel antibacterial products against C. difficile.

    Approaches: screening for natural products, probiotics, and screening for small compound library.

2. Development of a mucosal vaccine for the prevention of C. difficile infections.

    Approaches: Biodegradable polymers as vaccine delivery vehicle and discovery of novel antigens. 

3. Characterizing natural C. difficile habitats as a way for disease transmission. 

     Approaches: Bacterial-Protozoa interaction. Fresh and salt water as sources of bacterial contamination. 

4. Understanding the role of oral microbiota plays in oral cancer development and  proliferation.

    Approaches: Oral microbiota characterization. In-vitro and in-vivo disease model. 

近五年代表作

  1. Yang HT, Chen JW, Rathod J, Jiang YZ, Tsai PJ, Hung YP, Ko WC, Paredes-Sabja D, Huang IH* .Lauric Acid Is an Inhibitor of Clostridium difficile Growth in Vitro and Reduces Inflammation in a Mouse Infection Model. Front Microbiol. 2018 Jan 17;8:2635.
  2. Suzuki H, Tomita M, Tsai PJ, Ko WC, Hung YP, Huang IH*, Chen JW*. Comparative genomic analysis of Clostridium difficile ribotype 027 strains including the newly sequenced strain NCKUH-21 isolated from a patient in Taiwan. Gut Pathog. 2017 Nov 29;9:70.
  3. Liu YW, Chen YH, Chen JW, Tsai PJ, Huang IH*. Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model. Front Microbiol. 2017 Jul 25;8:1411.
  4. Yin JC, Fei CH, Lo YC, Hsiao YY, Chang JC, Nix JC, Chang YY, Yang LW, Huang IH*, Wang S*. Structural Insights into Substrate Recognition by Clostridium difficile Sortase. Front Cell Infect Microbiol. 2016 Nov 22;6:160.
  5. Hong YP, Wang YW, Huang IH, Liao YC, Kuo HC, Liu YY, Tu YH, Chen BH, Liao YS, Chiou CS. Genetic Relationships among Multidrug-Resistant Salmonella enterica Serovar Typhimurium Strains from Humans and Animals. Antimicrob Agents Chemother. 2018 Mar 26. pii: AAC.00213-18.
  6. Hung YP, Lee JC, Lin HJ, Chiu CW, Wu JL, Liu HC, Huang IH, Tsai PJ, Ko WC. Perceptions of Clostridium difficile infections among infection control professionals in Taiwan. J Microbiol Immunol Infect. 2017 Aug;50(4):521-526.
  7. Ji DD, Huang IH, Lai CC, Wu FT, Jiang DD, Hsu BM, Lin WC. Prevalence and characterization of enterotoxigenic Bacteroides fragilis and toxigenic Clostridium difficile in a Taipei emergency department. J Microbiol Immunol Infect. 2017 Feb;50(1):83-89. (Co-first author)