首頁師資〉專/兼任師資專長

張明熙

張明熙 (Chang, Ming-shi, Ph.D.)

生化所教授 分機:5677 E-mail: mschang@mail.ncku.edu.tw

研究興趣:

  本實驗室的研究計劃主要目標是由人體基因計劃的基因庫中去篩選有價值的新分子並鑑定該分子的生物功能,再進一步把該新分子研發成醫學新藥。研究的範圍包括 cytokines, cytokine receptors和 chemokines。藉這些新分子的研發,希望能對癌症或免疫系統失調或骨質疏鬆症或神經系統失調等疾病加以治療。

近五年代表作:*correspomding author

  1. KL Tsai, PL Hsieh, WC Chou,CH Hung, HL Yang, YC Chang, PM Chu,*MS Chang, SH Chan. IL-20 promotes hypoxia/reoxygenation-induced mitochondrial dysfunction and apoptosis in cardiomyocytes by upregulating oxidative stress by activating the PKC/NADPH oxidase pathway. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020 May; 1866, 5, 165684.
  2. YH Weng, WY Chen, YL Lin, JY Wang, *MS Chang. Blocking IL-19 signaling ameliorates allergen-induced airway inflammation. Frontiers in Immunology. 2019 Jan; 10, APR, 968.
  3. HH Wang, YH Hsu, *MS Chang. IL-20 bone diseases involvement and therapeutic target potential. Journal of biomedical science. 2018 Apr; 25, 1, 38.
  4. MS Chang, YH Hsu. The role of IL-20 in chronic kidney disease and diabetic nephropathy: Pathogenic and therapeutic implications. Journal of Leukocyte Biology. 2018 Nov; 104, 5, p. 919-923 5 p.
  5. YH Hsu, YY Yang, MH Huwang,YH Weng, IM Jou,PT Wu, TY Lin, LW Wu,*MS Chang. Anti-IL-20 monoclonal antibody inhibited inflammation and protected against cartilage destruction in murine models of osteoarthritis. PloS one. 2017 Apr;  12, 4, e0175802.
  6. YS Chiu, CH Hsing, CF Li, CY Lee, YH Hsu, *MS Chang. Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma. Scientific reports. 2017 Dec; 7, 1, 17609.
  7. YH Hsu, *MS Chang. IL-20 in rheumatoid arthritis. Drug Discovery Today. 2017 Jun; 22, 6, p. 960-964 5 p.
  8. YH Hsu, HH Li, JM Sung, WY Chen, YC Hou, YH Weng, WT Lai, CH Wu, * MS Chang. Interleukin-20 targets podocytes and is upregulated in experimental murine diabetic nephropathy. Experimental and Molecular Medicine. 2017 Mar; 49, 3, e310.
  9. YH Hsu,YS Chiu, WT Chen, KY Huang, IM Jou, PT Wu, CH Wu,*MS Chang. Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis. Scientific reports. 2016 Apr; 6, 24339.
  10. LH Chen, YM Yeh, YF Chen, YH Hsu, HH Wang, PC Lin, LY Chang, CK Lin, *MS Chang, MR Shen.Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy. Pain. 2020 Feb 12. doi: 10.1097/j.pain.0000000000001831. [Epub ahead of print]