首頁師資〉專/兼任師資專長

蔡坤哲

蔡坤哲 (Tsai, Kuen-Jer, Ph.D.)

臨床醫學研究所  教授    分機:4254       E-mail: kjtsai@mail.ncku.edu.tw

個人網址:http://icmmed.ncku.edu.tw/files/11-1341-11256.php

專長與研究興趣:

  1. 主要以分子生物學與細胞生物學之相關技術進行觀察與驗證,並搭配疾病動物模式、生理學以及行為分析等技術,來探討失智症相關的神經退化性疾病。
  2. 失智症相關的神經退化性疾病,包含阿茲海默氏症、額顳葉退化症、缺血性中風、蛛腦膜下腔出血、頭部外傷等。
  3. 探討失智症相關的致病機轉,並嘗試開發新的治療策略(包含幹細胞治療與藥物開發)。

近五年代表作: (*代表為通訊作者)

  1. Hung P.H., Yeh C.C., Hsiao C.Y., Sung P.S., Muo C.H., Sung F.C., Hung K.Y., Tsai K.J.* (2017) End stage renal disease is associated with development of dementia. Oncotarget, 8(64):107348-107355.
  2. Wu C.C., Wang I.F., Chiang P.M., Wang L.C., Shen C.J., Tsai K.J.* (2017) G-CSF-mobilized Bone Marrow Mesenchymal Stem Cells Replenish Neural Lineages in Alzheimer's Disease Mice via CXCR4/SDF-1 Chemotaxis. Molecular Neurobiology, 54(8):6198-6212.
  3. Sung P.S., Yeh C.C., Wang L.C., Hung P.H., Muo C.H., Sung F.C., Chen C.H., Tsai K.J.* (2017) Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder. Current Alzheimer Research, 14(3):309-316.
  4. Lee Y.H., Hsueh Y.W., Peng Y.H., Chang K.C., Tsai K.J., Sun H.S., Su I.J., Chiang P.M.* (2017) Low-cell-number, single-tube amplification (STA) of total RNA revealed transcriptome changes from pluripotency to endothelium. BMC Biology, 15(1):22.
  5. Wang L.C., Wu C.L., Cheng Y.Y., Tsai K.J.* (2017) Deletion of nuclear localizing signal attenuates pro-inflammatory activity of Prothymosin-alpha and enhances its neuroprotective effect on transient ischemic stroke. Molecular Neurobiology, 54(1):582-593.
  6. Wu P.T., Kuo L.C., Su F.C., Chen S.Y., Hsu T.I., Li C.Y., Tsai K.J.*, Jou I.M.* (2017) High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy. Scientific Reports, 7:40840.
  7. Tsai K.J., Sze C.I., Lin Y.C., Lin Y.J., Hsieh T.H., Lin C.H.* (2016) A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life. PLoS One, 11(10):e0165752.
  8. Wu M.H., Huang C.C., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Lin M.T.* (2016) Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. Molecular Neurobiology, 53(7):4961-71.
  9. Wu M.H., Chio C.C., Tsai K.J., Chang C.P., Lin N.K., Huang C.C., Lin M.T.* (2016) Obesity Exacerbates Rat Cerebral Ischemic Injury through Enhancing Ischemic Adiponectin-Containing Neuronal Apoptosis. Molecular Neurobiology, 53(6):3702-3713.
  10. Wu C.C., Lien C.C., Hou W.H., Chiang P.M., Tsai K.J.* (2016) Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease. Scientific Reports, 6:27358.
  11. Klionsky D.J.*,..., Tsai K.J.,...et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(2):443.
  12. Huang C.Y., Wang L.C., Wang H.K., Pan C.H., Cheng Y.Y., Shan Y.S., Chio C.C., Tsai K.J.* (2015) Memantine alleviates brain injury and neurobehavioral deficits after experimental subarachnoid hemorrhage. Molecular Neurobiology, 51(3):1038-52.
  13. Wang H.K., Lee Y.C., Huang C.Y., Liliang P.C., Lu K., Chen H.J., Li Y.C., Tsai K.J.* (2015) Traumatic brain injury causes frontotemporal dementia and TDP-43 proteolysis. Neurosciences, 300, 94-103.
  14. Liao H.W., Hung P.H., Hsiao C.Y., Liou H.H., Lin H.S., Huang T.H., Jou I.M., Tsai K.J.* (2015) Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy. PLoS One, 10(7):e0133278.
  15. Huang C.Y., Wang L.C., Shan Y.S., Pan C.H., Tsai K.J.* (2015) Memantine Attenuates Delayed Vasospasm after Experimental Subarachnoid Hemorrhage via Modulating Endothelial Nitric Oxide Synthase. International Journal of Molecular Sciences, 16(6):14171-80.
  16. Wu Y.T., Yu I.S., Tsai K.J., Shih C.Y., Hwang S.M., Su I.J., Chiang P.M.* (2015) Defining minimum essential factors to derive highly pure human endothelial cells from iPS/ES cells in an animal substance-free system. Scientific Reports, 5:9718.
  17. Huang C.Y., Li Y.C., Wang H.K., Sung P.S., Wang L.C., Sun Y.T., Pan C.H., Tsai K.J.* (2015) Stroke suggests increased risk of dementia. Current Alzheimer Research, 12(3):287-95.
  18. Wang I.F., Tsai K.J.*, Shen C.K.* (2015) Spermidine on neurodegenerative diseases. Cell Cycle, 14(5):697-8.
  19. Fang Y.S., Tsai K.J., Chang Y.J., Kao P., Woods R., Kuo P.H., Wu C.C., Liao J.Y., Chou S.C., Lin V., Jin L.W., Yuan H.S., Cheng I.H., Tu P.H., Chen Y.R.* (2014) Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients. Nature Communications, 5:4824.
  20. Huang L.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Prevalence, incidence, and comorbidity of clinically diagnosed obsessive-compulsive disorder in Taiwan: A national population-based study. Psychiatry Research, pii: S0165-1781(14)00707-0.
  21. Hung P.H., Huang Y.T., Hsiao C.Y., Sung P.S., Guo H.R., Tsai K.J.* (2014) Young stroke patients are at high risk for subsequent end-stage renal disease: a population-based observational study. Nephrology Dialysis Transplantation, 29(4): 873-878.
  22. Lu K., Wang H.K., Yeh C.C., Huang C.Y., Sung P.S., Wang L.C., Muo C.H., Sung F.C., Chen H.J., Li Y.C., Chang L.C., Tsai K.J.* (2014) Association between autoimmune rheumatic diseases and the risk of dementia. BioMed Research International, 2014: 861812.
  23. Shih Y.H., Tsai K.J., Lee C.W., Shiesh S.C., Chen W.T., Pai M.C., Kuo Y.M.* (2014) Apolipoprotein C-III is an amyloid-β-binding protein and an early marker for Alzheimer's disease. Journal of Alzheimer's Disease, 41(3):855-65.
  24. Wang H.K., Tsai K.J., Huang C.Y., Wang L.C., Lu K., Chen H.J., Lin C.W., Lee Y.J., Fang P.H., Chang L.C., Li Y.C.* (2014) Newly diagnosed dementia and increased risk of hemorrhagic stroke: a nationwide population-based study. Current Alzheimer Research, 11(3): 291-298.
  25. Tsai M.C., Tsai K.J., Wang H.K., Sung P.S., Wu M.H., Hung K.W., Lin S.H.* (2014) Mood disorders after traumatic brain injury in adolescents and young adults: a nationwide population-based cohort study. Journal of Pediatrics, 164(1): 136-141.
  26. Jou I.M., Lin C.F., Tsai K.J.*, Wei S.J. (2013) Macrophage-mediated inflammatory disorders. Mediators of Inflammation, 2013: 316482.
  27. Liu Y.C., Chiang P.M., Tsai K.J.* (2013) Disease animal models of TDP-43 proteinopathy and their pre-clinical applications. International Journal of Molecular Sciences, 14(10): 20079-20111.
  28. Lee Y.S., Chio C.C., Chang C.P., Wang L.C., Niu K.C., Tsai K.J.* (2013) Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke. Mediators of Inflammation, 2013, 512978.
  29. Wang I.F., Tsai K.J.*, Shen C.K.* (2013) Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: A new light for treatment of TARDBP/TDP-43 proteinopathies. Autophagy, 9(2), 1-2.
  30. Wang H.K., Lin S.H., Sung P.S., Wu M.H., Hung K.W., Wang L.C., Huang C.Y., Lu K., Chen H.J., Tsai K.J.* (2012) Population-based study on patients with traumatic brain injury suggests increased risk of dementia. Journal of Neurology, Neurosurgery, and Psychiatry, 83(11), 1080-1085.
  31. Wang L.C., Chang C.P., Chio C.C., Wu M.H., Lee Y.S., Huang C.Y., Tsai K.J.* (2012) Hypobaric hypoxia preconditioning attenuates experimental heatstroke syndromes via preinduction of heat shock protein 70. The American Journal of the Medical Sciences, 344(5), 383-390.
  32. Wang I.F., Guo B.S., Liu Y.C., Wu C.C., Yang C.H., Tsai K.J.*, Shen C.K.* (2012) Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. Proceedings of the National Academy of Science USA, 109(37), 15024-15029.
  33. Majumder P., Chen Y.T., Bose J.K., Wu C.C., Cheng W.C., Cheng S.J., Fang Y.H., Chen Y.L., Tsai K.J., Lien C.C., Shen C.K.* (2012) TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta Neuropathologica, 124(2), 231-45.
  34. Wang L.C., Huang C.Y., Wang H.K., Wu M.H. Tsai K.J.* (2012) Magnesium sulfate and nimesulide have synergistic effects on rescuing brain damage after transient focal ischemia. Journal of Neurotrauma, 29(7), 1518-1529.
  35. Tsai K.J., Yang C.H., Fang Y.H., Cho K.H., Chien W.L., Wang W.T., Wu T.W., Lin C.P., Fu W.M. and Shen C.K.J.* (2010) Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. Journal of Experimental Medicine, 207(8), 1661-1673.
  36. Tsai K.J., Yang C.H., Lee P.C., Wang W.T., Chiu M.J., Shen C.K.J* (2009) Asymmetric expression patterns of transthyretin transcripts in normal and a transgenic mouse model of Alzheimer's disease. Neuroscience, 159(2), 638-646.
  37. Tsai K.J., Tsai Y.C., Shen C.K.J.* (2007) G-CSF rescues the memory impairment of animal models of Alzheimer's disease. Journal of Experimental Medicine, 204(6), 1273-1280.