首頁師資〉教師指導學生

蔡佩珍

蔡佩珍  (Tsai, Pei-Jane, Ph.D.) 

醫技系 教授 分機5763    E-mail: peijtsai@mail.ncku.edu.tw

研究興趣

本實驗室的研究運用分子影像學探討微生物感染之致病機轉,以基因改造動物(冷光疾病報導小鼠)探討感染之發炎免疫疾病機制;建立人類感染性疾病之動物模式,尋找分子影像標的,篩選治療藥物,並運用到臨床治療微生物感染致病之轉譯醫學研究。主軸為:(1)A群鏈球菌之致病機轉 (2)困難梭狀桿菌感染之腸炎病理機制

近五年代表作

  1. YP Hung, HJ Lin, CJ Wu, PL Chen, JC Lee, HC Liu, YH Wu, FH Yeh, PJ Tsai*, and WC Ko*. The first case of severe Clostridium difficile ribotype 027 infection in Taiwan. J. Infect. 2014. 70:98-101.
  2. YP Hung, WC Ko, PH Chou, YH Chen, HJ Lin, YH Liu, HW Tsai, JC Lee, and PJ Tsai*. Proton pump inhibitor exposure aggravates Clostridium difficile colitis: evidences from a mouse model. J. Infet. Dis. 2015. 212:654-63. (Cover Page)
  3. YC Wu, JJ Lee, BY Tsai, YF Liu, CM Chen, PJ Tsai*, and TH Chen*. Potentially hypervirulent Clostridium difficile PCR Ribotype 078 Lineage isolates in pigs and possible implications for humans in Taiwan. Intern. J. Med. Microbiol. 2016. 306:115-22.
  4. YH Liu, YS Tsai*, SC Lin, NS Liao, MS Jan, CT Liang, SW Hsu, WC Chen, JM Sung, N Maeda, and PJ Tsai*. Quantitative PPARγ expressionaffects the balance between tolerance and immunity. Sci. Rep. 2016. 6:26646.
  5. BY Tsai, WC Ko, TH Chen, YC Wu, PH Lan, YH Chen, YP Hung, and PJ Tsai*. Zoonotic Potential of the Clostridium difficile RT078 Family in Taiwan. Anaerobe 2016. 41:125-30.
  6. JC Lee, YP Hung, HJ Lin, PJ Tsai*, and WC Ko*.Clostridium difficile Infections in Medical Intensive Care Units of a Medical Center in Southern Taiwan: Variable Seasonality and Disease Severity.PLoS One. 2016.11: e0160760.
  7. YP Hung, IH Huang, HJ Lin, BY Tsai, HC Liu, HC Liu, JC Lee, YH Wu, PJ Tsai*, and WC Ko*. Predominance of ribotype 017 among toxigenic isolates and ribotype 078 family among binary toxin producers. PLoS One. 2016.11: e0166159.
  8. WT Lee, YN Wu, YH Chen, SR Wu, TM Shih, TJ Li, LX Yang, CS Yeh, PJ Tsai*, DB Shieh*. Octahedron Iron Oxide Nanocrystal embedded on Clostridium difficile Spore and prohibited its Germination. Sci. Rep. 2017. 7:8124.
  9. YH Liu, YC Chang, WC Ko, YS Tsai, YH Chen, HC Lai, CY Wu, YP Hung, and PJ Tsai*. The ATP-P2X7 signaling axis is an essential sentinel for intracellular Clostridium difficile pathogen-induced inflammasome activation. Front. in Cell. & Infect. Microbiol. 2018.
  10. YH Liu, PH Wu, CC Kang, YS Tsai, CK Chou, CT Liang, JJ Wu, YS Lin, SY Wang, CC Liu, and PJ Tsai*. Group A Streptococcus subcutaneous infection-induced encephalopathy is attenuated by blocking circulating TNF. Front. Microbiol. 2019. 10:265.
  11. YH Chen, TJ Li, BY Tsai, LK Chen, YH Lai, MJ Li, CY Tsai, PJ Tsai* and DB Shieh*. Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection. Front. Microbiol. 2019. 10:1141.