首頁師資〉教師指導學生

蔡佩珍

蔡佩珍  (Tsai, Pei-Jane, Ph.D.) 

醫技系 副教授 分機5780    E-mail: peijtsai@mail.ncku.edu.tw

個人網址http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

 

研究興趣

  本實驗室的研究運用微生物感染角度結合分子影像學,建立基因改造動物(冷光疾病報導小鼠)用以探討感染及發炎免疫之相關機制;領域由建立人類感染性疾病之動物模式,尋找分子影像標的,運用到臨床治療,以進行微生物感染致病的轉譯醫學研究。主軸為二種細菌感染性疾病: (1)     A群鏈球菌之致病機轉探討A群鏈球菌感染導致壞死性機膜炎之病理機制。 (2)困難梭狀桿菌感染之腸炎病理機制建立感染之冷光報導動物模式探討先天免疫感染機制,並作為治療腸炎藥物篩選平台之轉譯研究。

近五年代表作

  1. LH Kuo,PJ Tsai, MJ Jiang, YL Chuang, L Yu, KTLai, and YS Tsai. Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signaling. 2010 Diabetologia 54:168-79.
  2. HY Huang, YS Tsai, JJ Lee, MC Chiang, CY Chiang, NT Lin, and PJ Tsai*. Mixed Infection of Beijing and non-Beijing strains and drug resistance pattern of Mycobacterium tuberculosis. 2010 J. Clin. Microbiol. 48:4474-80.
  3. CJ Hong*, PJ Tsai*, CY Cheng, CK Chou, HF Jheng, YC Chuang, CN Yang, SY Chen, SJ Tsai, YJ Liou, and YS Tsai. ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin. 2010 PLoS One 5:15333.
  4. SM Chen, YS Tsai, CM Wu, LC Wu, CS Chang, YH Liu, and PJ Tsai*. Streptococcal collagen-like surface protein 1 promotes adherence to respiratory epithelial cells.2010 BMC Microbiol. 10:320.
  5. YC Lin, YT Huang, PJ Tsai, TF Lee, NY Lee, CH Liao, SY Lin, WC Ko, and PR Hsueh. Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in Taiwan. 2011 Antimicrob. Agents Chemother. 55: 1701-5.
  6. HF Jheng, PJ Tsai, SM Guo, LH Kuo, CS Chang, IJ Su, and YS Tsai*. Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. 2012 Mol. Cell Biol. 32:309-19.
  7. YP Hung, PJ Tsai, KH Hung, HC Liu, CI Lee, HJ Lin, YH Wu, JJ Wu*, and WC Ko*. Impact of toxic Clostridium difficile colonization and infection among hospitalized adults at a district hospital in southern Taiwan. 2012 PLoS One 7:42415.
  8. CJ Wu, PJ Tsai, PL Chen, IC Wu, YT Lin, YH Chen, LR Wang, and WC Ko. Aeromonas aquariorum septicemia and enterocolitis in a cirrhotic patient.2012. Diagn. Microbiol. Infect. Dis. 74:406-8.
  9. JY Chen, PJ Tsai, HC Tai, RL Tsai, YW Chiou, ML Yeh, MJ Tang, YH Li, WC Tsai, LJ Lin, HL Wu, and YS Tsai*. Increased Aortic Stiffness and Impaired Elastic Fiber Stability in Obesity. Arterioscl. Throm. Vas. 2013. 33:839-46.
  10. YP Hung, HJ Lin, TC Wu, HC Liu, JC Lee, CI Lee, YH Wu, L Wan, PJ Tsai*, and WC Ko*. Clinical implications of fecal toxigenic and nontoxigenic Clostridium difficile colonization among hospitalized adults.2013 PLoS One (revised)