首頁師資〉教師指導學生

徐麗君

徐麗君 (Li-Jin Hsu, Ph.D.)

醫技系 副教授 分機:5765   E-mail: hsu.lijin@gmail.com

個人網址:http://mt.ncku.edu.tw/files/11-1371-14490.php#tabs|Teacher:1

研究興趣

  1. 探討WWOX腫瘤抑制蛋白質在癌症發展進程中之角色:我們過去的研究已經證實WWOX有調控細胞生長與凋亡的作用,WWOX所影響的細胞訊息傳遞路徑是我們將繼續深入探討的方向。
  2. 分析WWOX操控細胞生理作用的分子機制。
  3. 研究WWOX腫瘤抑制蛋白質在調控免疫細胞功能之角色。

近五年代表作:

  1. Lin CW, Jan MS, Kuo JH, Hsu LJ, and Lin YS. 2012. Protective role of autophagy in branched polyethylenimine (25K)- and poly(L-lysine) (30-70K)-induced cell death. Eur. J. Pharm. Sci. 47(5):865-874.
  2. Hong Q*, Hsu LJ*, Chou YT, Lu CY, Chen YA, and Chang NS. 2013. Self-aggregating TIAF1 in lung cancer progression. Translational Respiratory Medicine 1:5.
  3. Hsiao YW, Li CF, Chi JY, Tseng JT, Chang Y, Hsu LJ, Lee CH, Chang TH, Wang SM, Wang DD, Cheng HC, and Wang JM. 2013. CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma. Sci. Signal. 6(284):ra59.
  4. Tsai CW, Lai FJ, Sheu HM, Lin YS, Chang TH, Jan MS, Chen SM,Hsu PC, Huang TT, Huang TC, Sheen MC,Chen ST, Chang WC, Chang NS, and Hsu LJ**. 2013. WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma. Cell Death Dis. 4:e792.
  5. Fang YT, Wan SW, Lu YT, Yao JH, Lin CF, Hsu LJ, Brown MG, Marshall JS, Anderson R, and Lin YS. 2014. Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells. PLoS ONE 9(10):e110655.
  6. Lo JY, Chou YT, Lai FJ, and Hsu LJ**. 2015. Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp. Biol. Med. 240(3):383-391.
  7. Chang JY, Lee MH, Lin SR, Yang LY, Sun HS, Sze CI**, Hong Q, Lin YS, Chou YT, Hsu LJ**, Jan MS, Gong CX, and Chang NS**. 2015. Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget 6(6):3578-3589.
  8. Lee MH*, Su WP*, Wang WJ*, Lin SR*, Lu CY*, Chen YA*, Chang JY, Huang SS, Chou PY, Ye SR, Chen SJ, He H, Liu TH, Chou YT, Hsu LJ*, Lai FJ, Chen SJ, Lee HC, Kakhniashvili D, Goodman SR, and Chang NS. 2015. Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo. Oncotarget 6(6):3737-3751.
  9. Chen SJ, Lin PW, Lin HP, Huang SS, Lai FJ, Sheu HM, Hsu LJ, and Chang NS. 2015. UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget 6(10):8007-8018.
  10. Sze CI, Kuo YM, Hsu LJ, Fu TF, Chiang MF, Chang JY, and Chang NS. 2015. A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency. Cell Death Dis. 6:e1881.
  11. Hsu LJ, Chiang MF, Sze CI, Su WP, Yap YV, Lee IT, Kuo HL, and Chang NS. 2016. HYAL-2-WWOX-SMAD4 signaling in cell death and anticancer response. Front. Cell Dev. Biol., 4:141.
  12. Chen YD, Fang YT, Chang CP, Lin CF, Hsu LJ, Wu SR, Chiu YC, Anderson R, Lin YS. 2017. S100A10 Regulates ULK1 localization to ER-mitochondria contact sites in IFN-γ-triggered autophagy. J. Mol. Biol. 429(1):142-157.
  13. HsuLJ, Hong Q, Chen ST, Kuo HL, SchultzL,Heath J,Lin SR, Lee MH, Li DZ, Li ZL, Cheng HC, Armand G, Su WP, and Chang NS. 2017.Hyaluronan activates Smad4/Hyal-2/WWOX signaling and causes bubbling cell death when the signaling complex is overexpressed.Oncotarget 8(12):19137-19155.
  14. Chen YD, Fang YT, Cheng YL, Lin CF, Hsu LJ, Wang S, Anderson R, Chang CP, and Lin YS. 2017. Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-gamma-stimulated lung epithelial cells. Sci. Rep. 7(1):5676.