首頁師資〉教師指導學生

徐麗君

徐麗君 (Li-Jin Hsu, Ph.D.)

醫技所 副教授 分機:5765   E-mail: hsu.lijin@gmail.com

研究興趣:

  1. 探討腫瘤抑制蛋白質WWOX在癌症發展進程中之角色:我們過去的研究已經證實WWOX有調控細胞生長與凋亡的作用,將繼續深入探討WWOX所影響的細胞訊息傳遞路徑。
  2. 分析WWOX操控細胞生理作用的分子機制。
  3. 研究WWOX調控免疫細胞功能之角色。

近五年代表作:

  1. Lo JY, Chou YT, Lai FJ, and Hsu LJ**. 2015. Regulation of cell signaling and apoptosis by tumor suppressor WWOX. Exp. Biol. Med. 240(3):383-391.
  2. Chang JY, Lee MH, Lin SR, Yang LY, Sun HS, Sze CI**, Hong Q, Lin YS, Chou YT, Hsu LJ**, Jan MS, Gong CX, and Chang NS**. 2015. Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget 6(6):3578-3589.
  3. Lee MH*, Su WP*, Wang WJ*, Lin SR*, Lu CY*, Chen YA*, Chang JY, Huang SS, Chou PY, Ye SR, Chen SJ, He H, Liu TH, Chou YT, Hsu LJ*, Lai FJ, Chen SJ, Lee HC, Kakhniashvili D, Goodman SR, and Chang NS. 2015. Zfra activates memory Hyal-2+ CD3- CD19- spleen cells to block cancer growth, stemness, and metastasis in vivo. Oncotarget 6(6):3737-3751.
  4. Chen SJ, Lin PW, Lin HP, Huang SS, Lai FJ, Sheu HM, Hsu LJ, and Chang NS. 2015. UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget 6(10):8007-8018.
  5. Sze CI, Kuo YM, Hsu LJ, Fu TF, Chiang MF, Chang JY, and Chang NS. 2015. A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency. Cell Death Dis. 6:e1881.
  6. Hsu LJ, Chiang MF, Sze CI, Su WP, Yap YV, Lee IT, Kuo HL, and Chang NS. 2016. HYAL-2-WWOX-SMAD4 signaling in cell death and anticancer response. Front. Cell Dev. Biol., 4:141.
  7. Chen YD, Fang YT, Chang CP, Lin CF, Hsu LJ, Wu SR, Chiu YC, Anderson R, Lin YS. 2017. S100A10 Regulates ULK1 localization to ER-mitochondria contact sites in IFN-γ-triggered autophagy. J. Mol. Biol. 429(1):142-157.
  8. HsuLJ, Hong Q, Chen ST, Kuo HL, SchultzL,Heath J,Lin SR, Lee MH, Li DZ, Li ZL, Cheng HC, Armand G, Su WP, and Chang NS. 2017.Hyaluronan activates Smad4/Hyal-2/WWOX signaling and causes bubbling cell death when the signaling complex is overexpressed.Oncotarget 8(12):19137-19155.
  9. Chen YD, Fang YT, Cheng YL, Lin CF, Hsu LJ, Wang S, Anderson R, Chang CP, and Lin YS. 2017. Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-gamma-stimulated lung epithelial cells. Sci. Rep. 7(1):5676.
  10. Chou PY, Lai FJ, Chen YA, Sie YD, Kuo HL, Su WP, Wu CY, Liu TY, Wen KY, Hsu LJ, Sze CI,and Chang NS. 2019. Strategies by which WWOX-deficient metastatic cancer cells utilize to survive via dodging, compromising, and causing damage to WWOX-positive normal microenvironment. Cell Death Discov. 5:97.
  11. ChengYY, Chou YT, Lai FJ, Jan MS, Chang TH, Jou IM, Chen PS, Lo JY, Huang SS, Chang NS, Liou YT, Hsu PC,Lin YS, and Hsu LJ. 2020. Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice. Acta Neuropathol Commun.8:6.
  12. Chou YT, Lai FJ, Chang NS, Hsu LJ. 2020. Wwox deficiency causes downregulation of prosurvival ERK and Wnt pathways and abnormal homeostatic responses in mouse skin. Cell Death Dis. In revision.
  13. Huang SS, Hsu LJ, Chang NS. 2020. Functional role of WW domain-containing proteins in tumor biology and diseases: insight into the role in ubiquitin-proteasome system. FASEB BioAdvances. In press.