首頁師資〉教師指導學生

楊尚訓

楊尚訓 (Yang, Shang-Hsun, Ph.D.)

生理所 教授 分機:5453   E-mail: syang@mail.ncku.edu.tw

個人網頁:http://phys.med.ncku.edu.tw/files/11-1399-17857.php?Lang=zh-tw 

研究興趣

  1. 神經退化性疾病之基因轉殖大小動物模式建立
  2. microRNA於神經退化性疾病的影響
  3. microRNA對神經保護功能的調控機制
  4. 應用基因治療於人類遺傳性疾病的探討
  5. 胚胎發育及胚胎幹細胞的研究

近五年代表作

  1. Yusuf IO, Chen HM, Cheng PH, Chang CY, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH*. 2019. Fibroblast growth factor 9 activates anti-oxidative functions of Nrf2 through ERK signalling in striatal cell models of Huntington's disease. Free Radic Biol Med. 130:256-266.
  2. Yusuf IO, Cheng PH, Chen HM, Chang YF, Chang CY, Yang HI, Lin CW, Tsai SJ, Chuang JI, Wu CC, Huang BM, Sun HS, Yang SH*. 2018. Fibroblast growth factor 9 suppresses striatal cell death dominantly through ERK signaling in Huntington's Disease. Cell Physiol Biochem. 48(2):605-617.
  3. Her LS, Mao SH, Chang CY, Cheng PH, Chang YF, Yang HI, Chen CM, Yang SH*. 2017. miR-196a enhances neuronal morphology through suppressing RANBP10 to provide neuroprotection in Huntington’s disease. Theranostics 7(9):2452-2462.
  4. Hsu JY, Jhang YL, Cheng PC, Chang YF, Mao SH, Yang HI, Lin CW, Chen CM, Yang SH*. 2017. The truncated C-terminal fragment of mutant ATXN3 disrupts mitochondria dynamics in Spinocerebellar ataxia type 3 models. Front Mol Neurosci 10:196.
  5. Cheng PH, Chang YF, Mao SH, Lin HL, Chen CM, Yang SH*. 2016. Lentiviral transgenesis in mice via a simple method of viral concentration. Theriogenology. 86(6):1427-35.
  6. Fu MH, Li CL, Lin HL, Chen PC, Calkins MJ, Chang YF, Cheng PH, Yang SH*. 2015. Stem cell transplantation therapy in Parkinson's disease.Springerplus; 4:597.
  7. Fu MH, Li CL, Lin HL, Tsai SJ, Lai YY, Chang YF, Cheng PH, Chen CM, Yang SH*. 2015. The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One. 10(9): e0137637.
  8. Her LS, Lin JY, Fu MH, Chang YF, Li CL, Tang TY, Jhang YL, Chang CY, Shih MC, Cheng PH, Yang SH*. 2015. The differential profiling of ubiquitin-proteasome and autophagy systems in different tissues before the onset of Huntington’s disease models. Brain Pathol.25(4):481-90.
  9. Cheng PH, Li CL, Chang YF, Tsai SJ, Lai YY, Chan AW, Chen CM, Yang SH*. 2013. MiR-196a ameliorates phenotypes of Huntington Disease in cell, transgenic mouse and induced pluripotent stem cell models. Am J Hum Genet. 93(2): 306–312.
  10. Cheng PH, Li CL, Her LS, Chang YF, Chan AW, Chen CM, Yang SH*. 2013. Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. Brain Struct. Funct. 218(1):283-94.
  11. Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW. 2008. Towards a transgenic model of Huntington’s Disease in a non-human primate. Nature 453: 921-924.