首頁師資〉專/兼任師資專長

楊尚訓

楊尚訓 (Yang, Shang-Hsun, Ph.D.)

生理所副教授 分機:5453   E-mail: syang@mail.ncku.edu.tw

研究興趣

  1. 神經退化性疾病之基因轉殖大小動物模式建立
  2. microRNA於神經退化性疾病的影響
  3. microRNA對神經保護功能的調控機制
  4. 應用基因治療於人類遺傳性疾病的探討
  5. 胚胎發育及胚胎幹細胞的研究

近五年代表作

  1. Fu MH, Li CL, Lin HL, Chen PC, Calkins MJ, Chang YF, Cheng PH, Yang SH*. 2015. Stem cell transplantation therapy in Parkinson's disease.Springerplus; 4:597.
  2. Fu MH, Li CL, Lin HL, Tsai SJ, Lai YY, Chang YF, Cheng PH, Chen CM, Yang SH*. 2015. The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One. 10(9): e0137637.
  3. Her LS, Lin JY, Fu MH, Chang YF, Li CL, Tang TY, Jhang YL, Chang CY, Shih MC, Cheng PH, Yang SH*. 2015. The differential profiling of ubiquitin-proteasome and autophagy systems in different tissues before the onset of Huntington’s disease models. Brain Pathol.25(4):481-90.
  4. Cheng PH, Li CL, Chang YF, Tsai SJ, Lai YY, Chan AW, Chen CM, Yang SH*. 2013. MiR-196a ameliorates phenotypes of Huntington Disease in cell, transgenic mouse and induced pluripotent stem cell models. Am J Hum Genet. 93(2): 306–312.
  5. Chen YK, Huang AH, Cheng PH, Yang SH*, Lin LM*. 2013. Overexpression of Smad proteins, especially Smad7, in oral epithelial dysplasias. Clin Oral Investig. 17(3):921-32 (*Co-corresponding author)
  6. Cheng PH, Li CL, Her LS, Chang YF, Chan AW, Chen CM, Yang SH*. 2013. Significantly differential diffusion of neuropathological aggregates in the brain of transgenic mice carrying N-terminal mutant huntingtin fused with green fluorescent protein. Brain Struct. Funct. 218(1):283-94.
  7. Yang SH, Chan AW.. 2011. Transgenic animal models of huntington's disease. Curr. Top. Behav. Neurosci. 7:61-85.
  8. Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW. 2008. Towards a transgenic model of Huntington’s Disease in a non-human primate. Nature 453: 921-924.