首頁師資〉教師指導學生

陳昌熙

陳昌熙 (Chang-Shi Chen Ph.D.)                                     

生物化學暨分子生物學研究所 副教授 分機:5548   Email: cschen@mail.ncku.edu.tw

個人網址:http://myweb.ncku.edu.tw/~cschen/

專長說明:

遺傳學、化學生物學、生物化學、分子生物學

專長與研究興趣:

病菌宿主交互作用(pathogen-host interaction)

近五年代表作:

  1. Po-Lin Chen, Chi-Jung Wu, Pei-Jane Tsai, Hung-Jen Tang, Nan-Yao Lee, Ching-Chi Lee, Chia-Wen Li, Ming-Chi Li, Chun-Chun Ou, Chang-Shi Chen*, and Wen-Chien Ko*. Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences. PLoS One. 2014 Nov 6;9(11):e111213.*Corresponding authors
  2. Ru-Huei Fu, Yu-Chi Wang, Chang-Shi Chen, Rong-Tzong Tsai, Shih-Ping Liu, Wen-Lin Chang, Hsin-Lien Lin, Chia-Hui Lu, Jing-Rong Wei, Zih-Wan Wang, Woei-Cherng Shyu, Shinn-Zong Lin. Acetylcorynoline attenuates dopaminergic neuron degeneration and a-synuclein aggregation in animal models of Parkinson’s disease.Neuropharmacology. 2014 Jul;82:108-20.
  3. Po-Lin Chen, Chi-Jung Wu, Chang-Shi Chen, Pei-Jane Tsai, Hung-Jen Tang, and Wen-Chien Ko. A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent. Clin Microbiol Infect. 2014 Jul;20(7):O428-34.
  4. Hsu TI, Hsu CH, Lee KH, Lin JT, Chen CS, Chang KC, Su CY, Hsiao M, and Lu PJ. MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis. 2014 Apr 21;3:e99. doi: 10.1038/oncsis.2014.12.
  5. Ru-Huei Fu, Horng-Jyh Harn, Shih-Ping Liu, Chang-Shi Chen, Wen-Lin Chang, Yue-Mi Chen, Jing-En Huang, Rong-Jhu Li, Sung-Yu Tsai, Huey-Shan Hung, Woei-Cherng Shyu, Shinn-Zong Lin, Yu-Chi Wang. n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease. PLoS One. 2014 Jan 8;9(1):e85305.
  6. Han-Sheng Chuang, Hsiang-Yu Chen, Chang-Shi Chen, Wen-Tai Chiu. Immobilization of the Nematode Caenorhabditis elegans with Addressable Light-Induced Heat Knockdown (ALINK).Lab Chip. 2013 2013 Aug 7;13(15):2980-9.
  7. Ya-Luen Yang, Po-Hsien Huang, Hao-Chieh Chiu, Samuel K. Kulp, Ching-Shih Chen, Cheng-Ju Kuo, Huan-Da Chen, and Chang-Shi Chen. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. Biochem Biophys Res Commun. 2013 May 24;435(1):107-112.
  8. Ya-Luen Yang, Kah-Sin Loh, Bang-Yu Liou, I-Hua Chu, Cheng-Ju Kuo, Huan-Da Chen, and Chang-Shi Chen. SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans. Exp Gerontol. 2013 Mar; 48(3):371-9.
  9. Ting-Chen Chou, Hao-Chieh Chiu, Cheng-Ju Kuo, Ching-Ming Wu, Wan-Jr Syu, Wen-Tai Chiu, and Chang-Shi Chen.Enterohaemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegansin.Cell Microbiol. 2013 Jan;15(1):82-97.
  10. Chi-Jung Wu,Hsuan-Chen Wang,Chang-Shi Chen,Hung-Yu Shu,Ai-Wen Kao,Po-Lin Chen,and Wen-Chien Ko. Genome Sequence of a Novel Human Pathogen, Aeromonas aquariorum. J Bacteriol. 2012 Aug;194(15):4114-5.
  11. Chang-Shi Chen, Audrey Bellier, Cheng-Yuan Kao, Ya-Luen Yang, Huan-Da Chen, Ferdinand C O Los, and Raffi V. Aroian. WWP-1 is a novel modulator of the DAF-2 Insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS One.2010 Mar 2;5(3):e9494.
  12. Audrey Bellier, Chang-Shi Chen, Cheng-Yuan Kao, Hediye N. Cinar, and Raffi V. Aroian. Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans. PLoS Pathog.2009 Dec;5(12):e1000689.