首頁師資〉專/兼任師資專長

陳昌熙

陳昌熙 (Chang-Shi Chen Ph.D.)                                   

生物化學暨分子生物學研究所 副教授 分機:5548 

Email: cschen@mail.ncku.edu.tw 個人網址:http://myweb.ncku.edu.tw/~cschen/

專長與研究興趣:

病菌宿主交互作用(pathogen-host interaction)

近五年代表作:

 

  1. Huan-Da Chen, Cheng-Yuan Kao, Bang-Yu Liu, Shin-Whei Huang, Cheng-Ju Kuo, Jhen-Wei Ruan, Yen-Hung Lin, Cheng-Rung Huang, Yu-Hung Chen, Horng-Dar Wang, Raffi V. Aroian, and Chang-Shi Chen. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 2017 Feb;13(2):371-385.
  2. Po-Lin Chen, Yi-Wei Chen, Chun-Chun Ou, Tzer-Min Lee, Chi-Jung Wu, Wen-Chien Ko, and Chang-Shi Chen. A disease model of muscle necrosis caused by Aeromonas dhakensis infection in Caenorhabiditis elegans. Front Microbiol. 2017 Jan 4;7:2058.
  3. Po-Hsien Huang, Pei-Jung Lu, Li-Yun Ding, Po-Chen Chu, Wei-Yu Hsu, Chang-Shi Chen, Chih-Chieh Tsao, Bo-Heng Chen, Chung-Ta Lee, Yan-Shen Shan, and Ching-Shih Chen. TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic cctivation of VAV1. Oncogene. 2016 Nov 28. doi: 10.1038/onc.2016.378. [Epub ahead of print]
  4. Cheng-Ju Kuo, Jenn-Wei Chen, Hao-Chieh Chiu, Ching-Hao Teng, Tai-I Hsu, Pei-Jung Lu, Wan-Jr Syu, Sin-Tian Wang, Ting-Chen Chou, and Chang-Shi Chen. Mutation of the enterohemorrhagic Escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivo. Front Cell Infect Microbiol. 2016 Aug 12;6:82
  5. Han-Sheng Chuang, Wan-Jung Kuo, Chia-Lin Lee, I-Hua Chu, and Chang-Shi Chen. Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans. Sci Rep. 2016 Jun 16;6:28064.
  6. Han-Chu Chang*, Yu-Ting Huang*, Chang-Shi Chen*, Yi-Wei Chen, Yu-Tsung Huang, Jung-Chen Su, Lee-Jene Teng, Chung-Wai Shiau, and Hao-Chieh Chiu. In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA. J Antimicrob Chemother. 2016 Feb;71(2):449-59. *Equal contribution.
  7. Po-Lin Chen, Pei-Jane Tsai, Chang-Shi Chen, Ying-Chuan Lu, Hung-Mo Chen, Nan-Yao Lee, Ching-Chi Lee, Chia-Wen Li, Ming-Chi Li, Chi-Jung Wu, and Wen-Chien Ko. Aeromonas stool isolates from individuals with or without diarrhea in southern Taiwan: Predominance of Aeromonas veronii. J Microbiol Immunol Infect. 2015 Dec;48(6):618-24.
  8. Hsiang Yu, Huey-Jen Lai, Tai-Wei Lin, Chang-Shi Chen*, and Szecheng John Lo*. Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in C. elegans. Biochem J. 2015 Aug 15;470(1):145-54. *Corresponding authors.
  9. Po-Lin Chen, Chi-Jung Wu, Pei-Jane Tsai, Hung-Jen Tang, Nan-Yao Lee, Ching-Chi Lee, Chia-Wen Li, Ming-Chi Li, Chun-Chun Ou, Chang-Shi Chen*, and Wen-Chien Ko*. Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences. PLoS One. 2014 Nov 6;9(11):e111213. *Corresponding authors.
  10. Ru-Huei Fu, Yu-Chi Wang, Chang-Shi Chen, Rong-Tzong Tsai, Shih-Ping Liu, Wen-Lin Chang, Hsin-Lien Lin, Chia-Hui Lu, Jing-Rong Wei, Zih-Wan Wang, Woei-Cherng Shyu, Shinn-Zong Lin. Acetylcorynoline attenuates dopaminergic neuron degeneration and -synuclein aggregation in animal models of Parkinson’s disease. Neuropharmacology. 2014 Jul;82:108-20.
  11. Po-Lin Chen, Chi-Jung Wu, Chang-Shi Chen, Pei-Jane Tsai, Hung-Jen Tang, and Wen-Chien Ko. A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent. Clin Microbiol Infect. 2014 Jul;20(7):O428-34.
  12. Hsu TI, Hsu CH, Lee KH, Lin JT, Chen CS, Chang KC, Su CY, Hsiao M, and Lu PJ. MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis. 2014 Apr 21;3:e99. doi: 10.1038/oncsis.2014.12.
  13. Ru-Huei Fu, Horng-Jyh Harn, Shih-Ping Liu, Chang-Shi Chen, Wen-Lin Chang, Yue-Mi Chen, Jing-En Huang, Rong-Jhu Li, Sung-Yu Tsai, Huey-Shan Hung, Woei-Cherng Shyu, Shinn-Zong Lin, Yu-Chi Wang. n-Butylidenephthalide Protects against Dopaminergic Neuron Degeneration and α-Synuclein Accumulation in Caenorhabditis elegans Models of Parkinson's Disease. PLoS One. 2014 Jan 8;9(1):e85305.
  14. Han-Sheng Chuang, Hsiang-Yu Chen, Chang-Shi Chen, Wen-Tai Chiu. Immobilization of the Nematode Caenorhabditis elegans with Addressable Light-Induced Heat Knockdown (ALINK). Lab Chip. 2013 2013 Aug 7;13(15):2980-9.
  15. Ya-Luen Yang, Po-Hsien Huang, Hao-Chieh Chiu, Samuel K. Kulp, Ching-Shih Chen, Cheng-Ju Kuo, Huan-Da Chen, and Chang-Shi Chen. Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism. Biochem Biophys Res Commun. 2013 May 24;435(1):107-112.
  16. Ya-Luen Yang, Kah-Sin Loh, Bang-Yu Liou, I-Hua Chu, Cheng-Ju Kuo, Huan-Da Chen, and Chang-Shi Chen. SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans. Exp Gerontol. 2013 Mar; 48(3):371-9.
  17. Ting-Chen Chou, Hao-Chieh Chiu, Cheng-Ju Kuo, Ching-Ming Wu, Wan-Jr Syu, Wen-Tai Chiu, and Chang-Shi Chen. Enterohaemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegansin. Cell Microbiol. 2013 Jan;15(1):82-97.