首頁師資〉專/兼任師資專長

陳昌熙

陳昌熙 (Chang-Shi Chen Ph.D.)                                   

生物化學暨分子生物學研究所 教授 分機:5548 

Email: cschen@mail.ncku.edu.tw 個人網址:http://myweb.ncku.edu.tw/~cschen/

專長與研究興趣:

病菌宿主交互作用(pathogen-host interaction)

近五年代表作:

  1. Yi-Wei Chen, Wen-Chien Ko, Chang-Shi Chen*, and Po Lin Chen*. RIOK-1 is a suppressor of the p38 MAPK innate immune pathway in Caenorhabiditis elegans. Front Immunol. 2018 Mar, doi: 10.3389/fimmu.2018.00774 *Corresponding authors.
  2. Cheng-Ju Kuo, Sin-Tian Wang, Chia-Mei Lin, Hao-Chieh Chiu, Cheng-Rung Huang, Der-Yen Lee, Geen-Dong Chang, Ting-Chen Chou, Jenn-Wei Chen, and Chang-Shi Chen. A multi-omic analysis reveals the role of fumarate in regulating the virulence of Enterohemorrhagic Escherichia coli. Cell Death Dis. 2018 Mar 7;9(3):381.
  3. Cheng-Ju Kuo, Sin-Tian Wang, and Chang-Shi Chen. Detection of Enterohemorrhagic Escherichia coli Colonization in Murine Host by Non-invasive In Vivo Bioluminescence System. J Vis Exp. 2017 Jun;e56169, doi:10.3791/56169. (In Press)
  4. Jung-Chen Su, Yu-Ting Huang, Chang-Shi Chen, Hao-Chieh Chiu, Chung-Wai Shiau. Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant Staphylococcus aureus. Molecules. 2017 Dec 22;23(1). pii: E27. doi: 10.3390/ molecules23010027.
  5. Huan-Da Chen, Cheng-Yuan Kao, Bang-Yu Liu, Shin-Whei Huang, Cheng-Ju Kuo, Jhen-Wei Ruan, Yen-Hung Lin, Cheng-Rung Huang, Yu-Hung Chen, Horng-Dar Wang, Raffi V. Aroian, and Chang-Shi Chen. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Autophagy. 2017 Feb;13(2):371-385.
  6. Po-Lin Chen, Yi-Wei Chen, Chun-Chun Ou, Tzer-Min Lee, Chi-Jung Wu, Wen-Chien Ko, and Chang-Shi Chen. A disease model of muscle necrosis caused by Aeromonas dhakensis infection in Caenorhabiditis elegans. Front Microbiol. 2017 Jan 4;7:2058.
  7. Cheng-Ju Kuo, Jenn-Wei Chen, Hao-Chieh Chiu, Ching-Hao Teng, Tai-I Hsu, Pei-Jung Lu, Wan-Jr Syu, Sin-Tian Wang, Ting-Chen Chou, and Chang-Shi Chen. Mutation of the enterohemorrhagic Escherichia coli core LPS biosynthesis enzyme RfaD confers hypersusceptibility to host intestinal innate immunity in vivo. Front Cell Infect Microbiol. 2016 Aug 12; 6:82.
  8. Han-Sheng Chuang, Wan-Jung Kuo, Chia-Lin Lee, I-Hua Chu, and Chang-Shi Chen. Exercise in an electrotactic flow chamber ameliorates age-related degeneration in Caenorhabditis elegans. Sci Rep. 2016 Jun 16;6:28064.
  9. Han-Chu Chang*, Yu-Ting Huang*, Chang-Shi Chen*, Yi-Wei Chen, Yu-Tsung Huang, Jung-Chen Su, Lee-Jene Teng, Chung-Wai Shiau, and Hao-Chieh Chiu. In vitro and in vivo activity of a novel sorafenib derivative SC5005 against MRSA. J Antimicrob Chemother. 2016 Feb;71(2):449-59. *Equal contribution.
  10. Po-Lin Chen, Pei-Jane Tsai, Chang-Shi Chen, Ying-Chuan Lu, Hung-Mo Chen, Nan-Yao Lee, Ching-Chi Lee, Chia-Wen Li, Ming-Chi Li, Chi-Jung Wu, and Wen-Chien Ko. Aeromonas stool isolates from individuals with or without diarrhea in southern Taiwan: Predominance of Aeromonas veronii. J Microbiol Immunol Infect. 2015 Dec;48(6):618-24.
  11. Hsiang Yu, Huey-Jen Lai, Tai-Wei Lin, Chang-Shi Chen*, and Szecheng John Lo*. Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in C. elegans. Biochem J. 2015 Aug 15;470(1):145-54.*Corresponding authors.
  12. Po-Lin Chen, Chi-Jung Wu, Pei-Jane Tsai, Hung-Jen Tang, Nan-Yao Lee, Ching-Chi Lee, Chia-Wen Li, Ming-Chi Li, Chun-Chun Ou, Chang-Shi Chen*, and Wen-Chien Ko*. Virulence diversity among bacteremic Aeromonas isolates: ex vivo, animal, and clinical evidences. PLoS One. 2014 Nov 6;9(11):e111213. *Corresponding authors.
  13. Po-Lin Chen, Chi-Jung Wu, Chang-Shi Chen, Pei-Jane Tsai, Hung-Jen Tang, and Wen-Chien Ko. A comparative study of clinical Aeromonas dhakensis and Aeromonas hydrophila isolates in southern Taiwan: A. dhakensis is more predominant and virulent. Clin Microbiol Infect. 2014 Jul;20(7):O428-34.
  14. Han-Sheng Chuang, Hsiang-Yu Chen, Chang-Shi Chen, Wen-Tai Chiu. Immobilization of the Nematode Caenorhabditis elegans with Addressable Light-Induced Heat Knockdown (ALINK). Lab Chip. 2013 Jul 2;13(15):2980-9.
  15. Ya-Luen Yang, Kah-Sin Loh, Bang-Yu Liou, I-Hua Chu, Cheng-Ju Kuo, Huan-Da Chen, and Chang-Shi Chen. SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans. Exp Gerontol. 2013 Mar; 48(3):371-379.
  16. Ting-Chen Chou, Hao-Chieh Chiu, Cheng-Ju Kuo, Ching-Ming Wu, Wan-Jr Syu, Wen-Tai Chiu, and Chang-Shi Chen. Enterohaemorrhagic Escherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway in Caenorhabditis elegansin. Cell Microbiol. 2013 Jan;15(1):82-97.