首頁師資〉教師指導學生

洪建中

洪建中 (Hung, Jan-Jong, Ph.D.)

生物科技與產業科學系  教授     E-mail: petehung@mail.ncku.edu.tw

個人網址:http://ibbt.ncku.edu.tw/people/bio.php?PID=8

 

研究興趣:

 

本實驗室的研究主要目標在於利用分子生物和蛋白質體的技術在細胞和動物模式下進行肺癌形成機制的探討以及在肺癌誘發的動物模式下進行基因和藥物治療以及保健食品的癌症預防效果的評估及開發。期盼在肺癌防治上有所貢獻。

 

近五年代表作:

1.          Yi-Ting Wang, Jian-Ying Chuang, Meng-Ru Shen, Wen-Bin Yang, Wen-Chang Chang, Jan-Jong Hung (2008) Sumoylation of Sp1 Augments Its Degradation by Changing The Localization and Increasing The Sp1 Proteolytic Process. Journal of Molecular Biology 380(5): 869-885.

2.          Jian-Ying Chuang, Yi-Ting Wang, Shiu-Hwa Yeh, Yi-Wen Liu, Wen-Chang Chang, Jan-Jong Hung (2008) Phosphorylation by c-Jun NH2-terminal Kinase 1 Regulates the Stability of Transcription Factor Sp1 during Mitosis. Molecular Biology of the Cell 19(3): 1139-1151.

3.          Jan-Jong Hung, Yi-Ting Wang, Wen-Chang Chang (2006) Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. Molecular and Cellular Biology 26 (5): 1770-85.

4.          Jan-Jong Hung, Chih-Ying Wu, Pao-Chi Liao, Wen-Chang Chang (2005) Hsp90alpha Recruited by Sp1 Is Important for Transcription of 12(S)-lipoxygenase in A431 Cells. Journal of Biology Chemistry 280 (43): 36283-92.

5.          Jan-Jong Hung, Meng-Ti Hsieh, Ming-Jer Young, Chuan-Liang Kao, King CC, Wen Chang (2004) An External Loop Region of Domain III of Dengue Virus Type 2 Envelope Protein Is Involved in Serotype-specific Binding to Mosquito but not Mammalian Cells. Journal of Virology 78(1): 378-88.