首頁師資〉教師指導學生

張 堯

張堯 (Yao Chang. Ph.D.)                                     

國家衛生研究院感染症與疫苗研究所(兼任成大微免所)    副研究員(兼任副教授)

分機:3636轉65261   Email: yaochang@nhri.org.tw

個人網址:http://www.ncku.edu.tw/~microbio/teacher/ccy.htm 

專長與研究興趣:

腫瘤病毒之基因調控、致癌機轉、免疫互動及其疫苗開發

近五年代表作: 

  1. Hsiao, J.R., Chang, K.C., Chen, C.W., Wu, S.Y., Su, I.J., Hsu, M.C., Jin, Y.T., Tsai, S.T., Takada, K., and Chang, Y.*(2009). Endoplasmic reticulum stress triggers XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma. Cancer Research, 69:4461-4467. doi:10.1158/0008-5472.CAN-09-0277.
  2. Hsu, M.C., Hsiao, J.R., Chang, K.C., Wu, Y.H., Su, I.J., Jin, Y.T., and Chang, Y.* (2010). Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma. Modern Pathology, 23:1393-1403. doi:10.1038/modpathol.2010.130.
  3. Lee, C.H., Yeh, T.H., Lai, H.C., Wu, S.Y., Su, I.J., Takada, K., and Chang, Y.* (2011). Epstein-Barr virus Zta-induced immunomodulators from nasopharyngeal carcinoma cells upregulate interleukin-10 production from monocytes. Journal of Virology, 85:7333-7342. doi:10.1128/JVI.00182-11.
  4. Lan, Y.Y., Hsiao, J.R., Chang, K.C., Chang, J.S.M., Chen, C.W., Lai, H.C., Wu, S.Y., Yeh, T.H., Chang, F.H., Lin, W.H., Su, I.J., and Chang, Y.* (2012). Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9. Journal of Virology, 86:6656-6667. doi:10.1128/JVI.00174-12.
  5. Lan, Y.Y., Yeh, T.H., Lin, W.H., Wu, S.Y., Lai, H.C., Chang, F.H., Takada, K., and Chang, Y.* (2013). Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and 9 that synergistically promote cell invasion in vitro. PLoS ONE, 8:e56121. doi:10.1371/journal.pone.0056121.
  6. Chang, Y.*, Lan, Y.Y., Hsiao, J.R., and Chang, N.S. (2014). Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase. Experimental Biology and Medicine, in press. doi:10.1177/1535370214561957.