首頁師資〉專/兼任師資專長

王憶卿

王憶卿(Wang, Yi-Ching. Ph.D.)

藥理學研究所   講座教授 分機:5502   Email: ycw5798@mail.ncku.edu.tw

個人網址:https://pharma.ncku.edu.tw/members_view.php?qid=15&lmenuid=11&smenuid=6&lang=tw

專長與研究興趣

肺癌分子機制研究:

1. 癌症幹細胞 (cancer stem cell) 研究。

    A、外顯基因體 (epigenome-wide) 啟動子甲基化、染色體鬆緊度分析。

    B、轉錄調控與訊息傳遞分析。

2. 癌症微環境 (tumor microenvironment) 研究。

    A、細胞 exocytosis 與分泌體 (secretomics) 研究。

    B、細胞傳輸系統 (protein trafficking) 與訊息傳遞分析。

近五年代表作:

  1. Jen J, Liu CY, Chen YT, Wu LT, Shieh YC, Lai WW, Wang YC*. 2018. Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression.Cell Death Differ.2018 Sep 26. doi: 10.1038/s41418-018-0204-6.
  2. Tzeng HT, Su CC, Chang CP, Lai WW, Su WC, Wang YC*. 2018.Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype. Int J Cancer 143, 1753-1763. (cover article of Oct 1 2018 issue)
  3. Cho SH, Kuo IY, Lu PF, Tzeng HT, Lai WW, Su WC, Wang YC*. 2018. Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.Cell Death Dis. 9(9):868.
  4. Wang YS, Tzeng HT, Tsai CH, Cheng HC, Lai WW, Liu HS, Wang YC*. 2018. VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.Cancer Lett. 2018 437:79-88.
  5. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW* Wang YC*. 2017.Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis. Clin. Cancer Res.23(9):2335-2345. (highlighs of May 2017 issue)
  6. S.-Y. Liao, C.-W. Chiang, C.-H. Hsu, Y.-T. Chen, J. Jen, H.-F. Juan, W.-W. Lai, and Wang YC*.2017. CK1δ/GSK3b/FBXW7a axis promotes degradation of the ZNF322A oncoproteinto suppress lung cancer progression. Oncogene36(41):5722-5733.
  7. Jen J, Tang YA, Lu YH, Lin CC, Lai WW, Wang YC*.2017. Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. Mol Cancer 16(1):104.(highly cited paper)
  8. Jen J, Lin LL, Lo FY, Chen HT, Liao SY, Tang YA, Su WC, Salgia R, Hsu CL, Huang HC, Juan HF, Wang YC*. 2016. Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.Oncogene5;35(18):2357-69.
  9. Tang YA, Chen CH, Sun S, Cheng CP, Tseng VS, Hsu HS, Su WC, Lai WW, Wang YC*. 2015. Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucleic Acids Res. 43(3):1593-608
  10. Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, Chang YH, Liao PC, Chen RH, Yuan WC, Hsu HS, Yang MH, Hsu MT, Wu CY, Wang YC*. 2014. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumor metastasis. Nat Commun 2014 Sep 3;5:4804.