首頁師資〉專/兼任師資專長

王憶卿

王憶卿(Wang, Yi-Ching. Ph.D.)

藥理學研究所 講座教授 分機:5502   Email: ycw5798@mail.ncku.edu.tw

個人網址:http://www.ncku.edu.tw/~pharma/v2011/staff/10.html

專長與研究興趣:

肺癌分子機制研究:

  1. 癌症幹細胞 (cancer stem cell) 研究。

        A、外顯基因體 (epigenome-wide) 啟動子甲基化、染色體鬆緊度分析。

        B、轉錄調控與訊息傳遞分析。

  1. 癌症微環境 (tumor microenvironment) 研究。

        A、細胞 exocytosis 與分泌體 (secretomics) 研究。

        B、細胞傳輸系統 (protein trafficking) 與訊息傳遞分析。

近五年代表作:

  1. S.-Y. Liao, C.-W. Chiang, C.-H. Hsu, Y.-T. Chen, J. Jen, H.-F. Juan, W.-W. Lai, and Wang YC*.2017. CK1δ/GSK3b/FBXW7a axis promotes degradation of the ZNF322A oncoproteinto suppress lung cancer progression. Oncogene (accepted)
  2. Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, Lai WW, Wu LW, Wang YC*. 2016.Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis. Clin. Cancer Res.doi: 10.1158/1078-0432.CCR-16-1520 [Epub ahead of print] November 15, 2016.
  3. Jen J, Lin LL, Chen HT, Liao SY, Lo FY, Tang YA, Su WC, Salgia R, Hsu CL, Huang HC, Juan HF, Wang YC*. 2015. Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.Oncogene5;35(18):2357-69.
  4. Tang YA, Chen CH, Sun S, Cheng CP, Tseng VS, Hsu HS, Su WC, Lai WW, Wang YC*. 2015. Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer. Nucleic Acids Res. 43(3):1593-608
  5. Tsai CH, Cheng HC, Wang YS, Lin P, Jen J, Kuo IY, Chang YH, Liao PC, Chen RH, Yuan WC, Hsu HS, Yang MH, Hsu MT, Wu CY, Wang YC*. 2014. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumor metastasis. Nat Commun 2014 Sep 3;5:4804.
  6. Tang YA, Lin RK, Tsai YT, Hsu HS, Yang YC, Chen CY, Wang YC*. 2012. MDM2 overexpression deregulates the transcriptional control of RB/E2F leading to DNA methyltransferase 3A overexpression in lung cancer. Clin. Cancer Res. 18:4325-4333.
  7. Chen JY, Tang YA, Huang SM, Juan HF, Wu LW, Sun YC, Wang SC, Wu KW, Balraj G, Chang TT, Li WS*, Cheng HC*, Wang YC*. 2011. A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer Angiogenesis and Metastasis Pathways. Cancer Res. 71:473-483.
  8. Lin RK, Hsieh YS, Lin P, Hsu HS, Chen CY, Tang YA, Lee CF, Wang YC*. 2010. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.J. Clin. Invest., 120:521–532 (cover article).